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Biomedical subjects

C Constantinescu

Publications and source records attributed to C Constantinescu.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Comparative study of the immunogenicity of aqueous versus aluminium phosphate adsorbed split influenza vaccine C.I.

The antibody responses induced by the split influenza vaccine adsorbed on aluminium phosphate and the corresponding, nonadsorbed vaccine, both prepared in the Cantacuzino Institute, were studied in subjects belonging to three different age groups: 3-6, 10-15 and over 60 years of age, respectively. In all age groups the immunogenicity of the two vaccine preparations was similar, being uninfluenced by the level of preexisting antibodies. The immunogenicity of both vaccines was similar even in children considered to be non-primed. There were no differences in the persistence and specificity of antibodies induced by the two vaccines. No significant enhancement of the immunogenicity by aluminium phosphate was observed.

Adjuvants, Immunologic↗
PubMedDate not supplied

[5-Fluorouracil (ftorafur) in the treatment of acute pancreatitis. Indications for and efficacy of its use].

The main aim of the complex medical treatment in acute pancreatitis is the inhibition of exocrine pancreas secretion and decrease or annulment of the proteolytic effect, of autolysis, of its enzymes, both on the gland itself and on the neighbouring tissues. The authors introduced cytostatics of the 5-fluorouracil type (ftorafur) in the medical and/or medico-surgical treatment of 30 cases of acute pancreatitis admitted to the "Caritas" Surgical Clinic, during 1986-1987. The drugs lead to DNA-RNA inhibition and reduce significantly the pancreatic exocrine activity. Efficiency of 5-fluorouracil within the other therapeutic methods is proved by the results obtained, especially by the favourable rapid clinical evolution, blood amylase normalization in 48-72 hours, arrest in evolution of the pancreatic lesions. The treatment is economical and has no side effects. It may be also used for the digestive fistulae with pancreatic content or for the pure pancreatic fistulae.

Acute Disease↗
PubMedDate not supplied

[Papillosphincterotomy of Oddi's sphincter (experience in 401 cases)].

The authors present a statistics covering 401 cases in whom sphincterotomy of the Oddi sphincter was performed, in most of them for treating stenosing inflammations (papillo-odditis). Indications of this method are analized, for the surgical treatment of hydatic cysts opening in the biliary pathways, and of cholestatic hepatitis. Considerations are made on the place of sphincterotomy in the treatment of the main biliary pathway and the results are analized obtained with this method, as well as re-interventions after sphincterotomy. Some conclusions can be made on the indications and the contraindications of the method in the surgery of the hepato-choledocus.

Ampulla of Vater↗
PubMedDate not supplied

[Splenectomy in chronic hepatitis with an autoimmune component].

The authors present a synthesis of studies performed on the role of the spleen in chronic active-digestive hepatitis with auto-immune participation. The study was based on a group of 48 patients out of which a lot of 20 patients was selected, with histological diagnosis of chronic active and aggressive hepatitis, in whom the presence of AgAu was ascertained, as well as of antiliver antibodies. From the immunological viewpoint, the effect of splenectomy was manifested, by a rapid and significant decrease of anti-liver antibodies mainly produced by the spleen, immediately following the intervention. In most of the patients the IgM antibodies disappeared somewhat later. At the same time the chronic hepatitis lesions were stabilized, the biological signs were improved and the clinical evolution of the patients was good. The authors consider that splenectomy in this category of hepatopathies is an immuno-suppressive therapy that may arrest the evolution towards cirrhosis.

Adult↗
PubMedDate not supplied

[Ulcer of the transverse colon].

This very rare affection of unknown origin, achieves a macroscopic and microscopic aspect similar to that described by Cruveillhier at the level of the stomach. The authors present a case of ulcer located on the transverse colon, at the free margin, with stenosing evolution and coexisting with duodenal ulceration of chronic character. The patient also had portal hypertension in the third stage and arteriopathy that had been diagnosed previously.

Colonic Diseases↗