Search PubMed⌕ Search

Biomedical subjects

C Collins-Williams

Publications and source records attributed to C Collins-Williams.

At least 19 recordsLinked to original sources
PubMed1987

Antihistamines in asthma.

Reports in the literature have suggested that antihistamines are contraindicated in asthma because they dry the secretions in the upper and lower respiratory tracts. However, the consensus is that this is not the case. There may be a subset of asthmatics who report wheezing and a feeling of tightness in the chest after taking antihistamines but most of those who have severe perennial allergic rhinitis do not have adverse reactions and indeed benefit considerably from antihistamines.

Asthma↗
PubMed1985

Clinical spectrum of adverse reactions to tartrazine.

Tartrazine, a common additive in foods and drugs, often causes adverse reactions such as recurrent urticaria, angioedema, and asthma and is frequently implicated in hyperkinesis. This paper summarizes the recent literature on the subject and outlines a practical approach for the practicing physician to diagnose and treat these patients in an optimal manner.

Angioedema↗
PubMed1982

Evaluation of home-monitoring of asthmatic children with the mini-Wright peak flow meter.

The amount of medication required to control asthmatic wheezing varies from patient to patient. While the amount required can be assessed clinically from history and physical examination, an objective measurement to assess the patient's requirements is highly desirable. For this purpose the mini-Wright peak flow meter was used. The patient was shown in the office how to use the meter and then sent home to use the meter three times daily for 2 weeks and record each reading on the chart provided. After 2 weeks the chart and meter were mailed to the office where the patient's readings were compared with normal values. Then the patient's medications could be adjusted if necessary. A study of 55 patients showed that this is a very valuable method to assist the practicing physician in prescribing sufficient medication for adequate control, particularly in those patients who minimize their symptoms, either intentionally or unintentionally, so that the physician cannot make an adequate judgment. It was also very useful for convincing the parents or patients that continuous medication is necessary in many cases where they felt PRN medication to be sufficient. The use of this instrument should become a routine part of the management of all difficult asthmatic patients.

Adolescent↗
PubMed1982

Aspirin-induced asthma in children.

Aspirin-sensitive asthma is not well documented in children. It may present as a triad of (1) allergic rhinitis, (2) nasal polyps and/or sinusitis and (3) bronchial asthma precipitated by aspirin. Four cases in children are presented. The pathophysiology probably involves the biosynthesis of prostaglandins.

Acetylation↗
PubMed1981

Death from asthma.

The factors associated with the deaths of 31 asthma patients were examined. The subjects, whose deaths occurred in the period 1967 through 1979, had all received some care at the Hospital for Sick Children in Toronto, but only nine died there. The greatest single cause of death was the inappropriate use of beta-agonists, with or without the concurrent use of epinephrine. In seven patients an asthma attack that occurred outside hospital progressed so rapidly that there was insufficient time for them to obtain adequate therapy. In five cases the assessment of the patient's condition or the therapy recommended by the attending physician appeared to have been inadequate. Two patients suffered an acute attack in hopital and did not respond to treatment that appeared to have been adequate. In six cases the available information was insufficient to indicate the cause of death. Over half (18) of the deaths occurred in teenagers. Various ways of preventing death from asthma are discussed, including better education of physicians and patients, adequate management of factors that provoke bronchospasm, sufficient follow-up -- especially in teenagers -- and the use of approaches with teenagers that encourage better compliance.

Acute Disease↗
PubMed1977

Oral salbutamol therapy of asthma in young children.

Twenty-one young asthmatics, 2-6 years of age (mean 4 years), were given an open trial of salbutamol syrup to assess its safety. Each patient was given 1 mg, then 2 mg, q8h for two weeks. Only one patient experienced side-effects and this was at the 2 mg dose. It is concluded that salbutamol syrup is safe at a dose of 1 to 2 mg q8h for the asthmatic children in this age group.

Administration, Oral↗
PubMed1977

The status of immunotherapy in children--what are the problems?

Immunotherapy, widely used in the treatment of atopic disease, poses many problems. In asthma the multiple etiologic factors involved make clinical trials of its efficacy difficult to evaluate and immunological studies are badly needed. Allergen extracts of standard potency are essential. The author feels that practicing allergists must improve their knowledge of and expertise in immunotherapy if the patient is to derive maximum benefit from it.

Adolescent↗
PubMed1977

The long-term use of beclomethasone dipropionate for the control of severe asthma in children.

Thirty-nine children with severe asthma who had been treated with aerosol inhalations of beclomethasone dipropionate for 33 to 34 months were studied. Twenty-eight were still benefitting from the drug, thrush had occurred in three, and only six of the 20 originally steroid-dependent now required steroid orally. The authors feel that this is an efficacious, safe medication but stress that systemic steroid therapy should be promptly reinstituted during acute exacerbations in steroid-dependent patients.

Adolescent↗