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Biomedical subjects

C Colin

Publications and source records attributed to C Colin.

At least 109 records · Page 6Linked to original sources
PubMed1981

[Comparison of therapeutic activity of idoxuridine and acyclovir in experimentally-induced herpetic keratitis in rabbits (author's transl)].

Antiherpetic activity of a new antiviral agent, Acyclovir (ACV), was compared with that of Idoxuridine (IDU) in the treatment of keratitis induced in rabbits by type I herpes simplex virus (HSV). After topical application for 5 days, both compounds were well tolerated, but ACV was significantly more effective than IDU. Virological tests demonstrated that virus multiplication continued for a shorter period in eyes treated with ACV than in those of controls, or of animals treated with IDU, but early viral regrowth was possible. Using two HSV markers, seroneutralization and thermal sensitivity of cell culture development, variations were observed in a rabbit treated with IDU and in a control animal also. Epithetial regeneration after treatment was assessed by optical microscopy and by scanning and transmission electron microscopy. Epithelial scarring was observed to be almost complete in rabbits treated with IDU. The correlation between therapeutic, virological, and histological results in positive evidence for the use of ACV in HSV-induced ocular lesions.

Acyclovir↗
PubMed1978

Relationship of mastodynia with its endocrine environment and treatment in a double blind trial with lynestrenol.

Serum analysis carried out about 7 days before menstruation in 33 patients with mastodynia and 20 controls confirmed that progesterone is frequently decreased and prolactinaemia increased in the patients with mastodynia compared with controls of the same age. In a double blind trial, administration of Lynestrenol to 47 patients with mastodynia (each of whom was given 10 mg per day from the 10th to the 24th day of the cycle) resulted in a significant improvement of this condition in 80% of the treated cases. The therapeutic failures may be explained by anomalies in the secretion of prolactin, and may possibly be linked to individual sensitivity factors.

Adult↗
PubMed1978

Radioimmunoassay for protein p28 of murine mammary tumor virus in organs and serum of mice and search for related antigens in human sera and breast cancer extracts.

The main protein of the core of murine mammary tumor virus, with a molecular weight of 28,000 (p28), was solubilized by deoxycholate treatment of the virus and purified by Ultrogel ACA-54 filtration and hydroxyapatite chromatography. This protein was used as labeled antigen in a highly specific and reproducible radioimmunoassay. Organ extracts of uninfected C57BL mice did not contain p28, but organ extracts of infected RIII mice did contain the antigen. Despite the high content in the mammary gland, the level of p28 in the other organs was identical in male and female mice. Sera of uninfected mice and the majority of the sera of infected mice did not contain the antigen. The investigation included 338 human sera (50, normal; 157, breast cancer; 77, polycystic disease; 32, benign mastopathy; 12, fibroadenoma; 10, at risk of developing breast cancer). None contained an antigen related to p28. Eight of 24 extracts of human breast cancer gave results that appeared weakly positive, possibly as a result of proteolysis. Extracts of healthy breast tissue and the serum from the breast arterial and venous blood of corresponding patients were negative.

Animals↗
PubMed1978

[Breast check-up and high risk factors in breast cancer screening (author's transl)].

Between 1966 and 1977, 142 breast cancers have been discovered in 85 250 women among 120,000 routine clinical examinations. Comparison between the information given by mammography alone compared with the panel of specialized techniques (cytology, thermography, mammography, echography) shows superiority for the latter. Complete breast check-ups have doubled the percentage of cancers discovered in the women that were examined (from 0,8% to 1,8%). A family history of breast cancer does not help in the discovery of cancer, except in cases of mammary changes noticed by the patient herself. However, these women have to be checked regularly, because the number of cancers diagnosed does not decrease at subsequent visits. The generalized practice of self-examination and of less mutilating treatment should encourage patients to consult earlier, as they have less fear that mutilating surgery will be performed.

Adult↗