[Prenatal echographic diagnosis of spina bifida].
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Abnormalities, Multiple↗
Biomedical subjects
C Coicaud
Publications and source records attributed to C Coicaud.
[Treatment of hydronephrosis caused by obstruction of the pyeloureteral junction diagnosed before birth].
From 1981 to 1987, the authors observed 69 patients with ureteropelvic junction obstruction diagnosed by antenatal ultrasound, representing a total of 77 pathological renal units. Seventy renal units were treated by ureteropelvic resection, one renal unit returned to normal without treatment. There were 3 primary nephrectomies and 3 secondary nephrectomies for non-improvement after percutaneous nephrostomy. An early antenatal surgical management of ureteropelvic obstruction after antenatal ultrasound diagnosis does not seem to give better results than when diagnosis is made at a later stage. The interest of the antenatal diagnosis is not as important as for other uropathies such as urecterocele, mega-ureter or posterior urethral valves.
Constriction, Pathologic↗
[Ectopia cordis: early echographic diagnosis in utero].
Having had a case of ectopia cordis which was diagnosed early in utero, the authors have analysed the information they have obtained and they have suggested what steps to take according to the features revealed by the ultrasound pictures and taking into account the different anatomical forms. They have also considered the lesions that are associated with this condition and the principal prognostic features.
Abnormalities, Multiple↗
[Pena-Shokeir syndrome. Malformed sequence. 2 case reports].
The authors report two cases of Pena-Shokeir syndrome; they emphasize its place among the numerous etiologies of hydramnios, among the different AMC, particularly the autosomal recessive entities.
Adult↗
[Fetal ascites as a manifestation of infantile sialidosis. Significance of a study of oligosaccharides in amniotic fluid].
Non immune hydramnios and fetal ascite are demonstrated at 31 weeks gestation. There is no familial story. All etiologic investigations (repeated ultrasonographic examinations, amniocentesis) are negative. The delivered girl has a normal development. She presents a congenital ascite and edema. The diagnosis of sialidosis (mucolipidosis type I) is supported by the early finding of vacuolated lymphocytes, the excretion of oligosaccharides in the urine and, finally, the results of the study of alpha-D-neuraminidase fibroblasts and others lysosomal enzymes activities. Oligosaccharides and enzymic studies provide same results in amniotic fluid. Authors point the particular interest of amniotic fluid oligosaccharides study when the etiologic diagnosis of idiopathic fetal ascite or hydrops is to be done.
Adult↗
[Evaluation of 100 autopsies performed in the maternity service of the Hôtel-Dieu in Lyon during an 18 month period].
100 Necropsies have been performed from January 1983 to June 1984, on 53 abortus and stillborn and 47 therapeutic terminations of pregnancy. All fetuses came from the same obstetric unit. Half spontaneous fetal deaths remained of unknown aetiology; in 18 cases (34%) placental, maternal or pregnancy pathology existed; fetal abnormalities were discovered in 10 (18%). As for therapeutic interruptions of pregnancy (the indications of which are detailed) the importance of ultrasonography emphasized since this technique allowed 25 of the 47 prenatal diagnosis. The importance of necropsy to help precise diagnosis and subsequent counselling is also recalled.
Abortion, Therapeutic↗
[Pulmonary adenomatoid malformation. Prenatal diagnosis].
A case of congenital cystic adenomatoid malformation of the lung (Type III) is presented with prenatal ultrasound findings at 21st week. Operation in neonatal period. Association with sequestration. The first healing.
Female↗
[General anthropometric data].
Presentation of ultrasonography moving data about the 1st trimester pregnancy: visualization of heart beating of fetal movements, measurements, aspect and shape of the main organs and of the fetal skeleton.
Anthropometry↗
[Prenatal diagnosis of a de novo trisomy case 9q-47,XX,+9 del(q33----qter)].
A case of de novo trisomy 9q- (deletion q33----qter) in utero diagnosed is reported. Features of this syndrome are described, compared with those of trisomy 9p et total trisomy 9. The possibility of prenatal diagnosis and the similarity of some features with nail-patella syndrome are focused.
Chromosome Aberrations↗
[An original method of echographic fetal measurements].
The authors have tried to look at the graphs of ultrasound growth in their population in order to establish a base pattern. The infants were divided into groups according to their frame and a study of each diameter was made for each group. The authors show that all babies that start off from the same point arrive at their final stature which is different from all others because of their own rates of growth. The curve which is suggested fits in with this spread. The way it is built up has been explained as well as the follow-up studies that show that it is valid. The discussion points out that the rates of growth can be measured; and the value of the diameter of the thorax.
Fetus↗
[Problems posed by prenatal diagnosis of abdominal wall malformations].
The authors present 6 observations of in utero detected abdominal wall defect : 2 laparoschisis and 4 omphaloceles. In three cases the diagnosis have been done prior week 20, by systematic AFP assay for amniocentesis performed for cytogenetic or metabolic reasons; the pregnancy was terminated. In three other cases, the pregnancy was complicated by hydramnios after week 30; amniocentesis for AFP and echography were performed to detect fetal malformations after associated with hydramnios. The detected abdominal wall anomaly was not alone: two fetus had an abnormal caryotype (trisomy 18), three other presented a polymalformative syndrome, a Beckwith-Wiedemann syndrome was discussed for the last child. The in utero diagnosis of omphalocele or laparoschisis implicates difficulties for genetic counselling, particularly if the diagnosis is done prior week 20. These anomalies can be treated with surgical management, but frequency of associated malformations must be underlined. it is important for genetic counselling to know the family history, the amniotic fluid cells caryotype, and an ultrasound scanning performed to reveal any other malformations.
Abdominal Muscles↗
[Ultrasonography and alpha fetoprotein determination: two complementary tests in the prenatal diagnosis of anencephaly].
From an observation, authors underline the interest of two complementary tests: ultrasonography and amniotic fluid AFP determination. About the reported case, the chronology of facts is unusual: ultrasonography led initially to suspect anomaly, then elevated AFP result confirmed the malformation.
Anencephaly↗
[The antenatal diagnosis before 20 weeks of an omphalocoele and a failure of development of the abdominal wall (author's transl)].
We report 2 cases of malformations occuring in the region of the umbilicus which were diagnosed by amniocenteses before the 20th week of pregnancy (with levels of alphafetoprotein) and echography. Failure of development of the abdominal wall was only diagnosed for certain after the therapeutic abortion had been carried out. The omphalocoele was diagnosed for certain by echography at the 19th week after anencephaly and spina bifida had been eliminated in spite of an abnormally high rise in the level of amniotic fluid alphafetoprotein (100.000 microgram/l). We have not found any similar cases in the literature at this gestational age. These observations prove the value of combining the estimation of alphafetoprotein level in the amniotic fluid when making antenatal diagnoses because of the age of the mother (after the age of 38), with echography specially directed to searching for such apparent morphological abnormalities.
Abdominal Muscles↗