Biomedical subjects
C Coërs
Publications and source records attributed to C Coërs.
[Clinical, histological and electrophysiologic study of neuropathies caused by vincristine treatment].
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[Anatomo-clinical observations in a case of acute multiple sclerosis in the "postpartum period"].
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Motor innervation and fiber type pattern in amyotrophic lateral sclerosis and in Charcot-Marie-Tooth disease.
A quantitive study of the terminal innervation ratio (TIR) was conducted using 18 amyotrophic lateral sclerosis (ALS) and 12 Charcot-Marie-Tooth disease (CMT) muscle biopsies. Morphometric and histochemical analyses of muscle fibers were performed in 9 ALS and 6 CMT biopsies. The results revealed that TIR and type grouping were significantly greater in CMT than in ALS. The proportion of type 3 fibers was higher in ALS, though the proportion of intermediate and type 0 fibers was significantly higher in CMT. The atrophy factor was significantly greater in type 3 than in types 1 and 2 fibers, but it was not significantly different in type 0 and intermediate fibers as compared to types 1 and 2, It appears, therefore, that CMT has a better capacity for collateral reinnervation than ALS. Type 0 and intermediate fibers may represent altered endproducts of successful collateral reinnervation.
Benign monoclonal gammopathy and relapsing polymyositis.
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Unclassified familial myopathy resembling Steinert disease, without myotonia.
A familial myopathy with predominantly proximal muscle atrophy is described. Although several clinical features such as sternomastoid and brachioradialis muscle involvement suggested Steinert disease, myotonia was not demonstrated by clinical examination or EMG. Histological data were consistent with myotonic dystrophy.
[Choreo-athetosis with hepato-cerebral degeneration in a patient with a portocaval shunt (author's transl)].
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[Progressive external ophtalmoplegia with abnormal mitochondria in striated muscles (author's transl)].
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[The histochemistry of normal muscle fibers].
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[Histopathology of the motor units in neuromuscular diseases].
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[Changes of motor innervation in myasthenic muscles in relation to age (author's transl)].
The motor innervation in muscle biopsies from 45 myasthenic patients was studied by intravital staining with methylene blue. The enzymatic pattern and fibre type distribution was analysed in 12 cases. Quantitative data including the proportion of elongated motor endings and the terminal innervation ratio (TIR) of motor axons, were compared to histochemical data and to clinical data including age of patients. The incidence of elongated motor endings tends to be greater in younger patients, whereas an increased collateral ramification of motor axons occurs only after the age of 50. Small type III fibers suggesting denervation are also found in elderly patients only. The significance of these morphological differences in relation to age is discussed.