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Biomedical subjects

C Clarke

Publications and source records attributed to C Clarke.

174 records · Page 10Linked to original sources
PubMedDate not supplied

Neurotoxicity of radiation sensitizers in the mouse.

The neurotoxicity of a homologous series of 1-substituted, 2-nitroimidazole compounds, synthesized in this laboratory, has been studied in mice. This involves measurement of the enzyme beta-glucuronidase in the distal sciatic, tibial and common peroneal nerves. The amount of compound required to give a known neurotoxic response, in terms of elevated beta-glucuronidase (arbitrarily set at 60% increase) has been determined. A correlation between increased number of methylene groups (N) in the side chain and neurotoxicity has been shown. A correlation between increased neurotoxicity and effective octanol; water coefficient, at pH 7.4, was also established. A more soluble version of the n = 4 member of the homologous series, that is the compound RSU 1047 (NSC 328897), and misonidazole also fit this correlation of partition coefficient and dose.

Animals↗
PubMedDate not supplied

The effects of restraint stress on intake of preferred and nonpreferred solutions in rodents.

In these experiments we determined whether stress influenced intake of different flavored test solutions or only those that were preferred. In a series of studies, rats or hamsters were exposed to acute (1 h) or repeated (3 h/day for 3 days) restraint stress immediately followed by access to one of four tastants (saccharin, salt, citric acid, or quinine solutions) paired with water in a 24-h preference test. As rats prefer salt and hamsters do not, both species were used to test the effects of stress on preferred vs. nonpreferred solutions using the same stimulus. Acute restraint inhibited intake of saccharin in rats but had no effect on preference, indicating that suppression of intake was not due to changes in hedonic response. Restraint had no effect on saccharin intake of hamsters but significantly increased salt intake. However, as the preference ratio remained low for the solution (0.26), the stress-induced increase in salt intake was probably associated with a disturbance of sodium and fluid balance rather than a change in sensory perception. This was supported by stress having no effect on intake of nonpreferred solutions in rats or hamsters. Repeated restraint had no effect on salt or saccharin intake of rats when test solutions were presented after stress, but rats showed no preference for saccharin in a subsequent study in which the solution was associated with onset of stress. These results indicate that stress has specific effects on saccharin and salt intake that are not limited to preferred solutions.

Animals↗
PubMedDate not supplied

Psychopharmacologic management of women with common mental health problems.

This article reviews the essential aspects of the psychopharmacologic management of women with mental health problems, with particular emphasis on the role of the nurse-midwife as a primary care provider. The article also addresses the neurobiology of psychopharmacology, pharmacokinetics, and the selection of pharmacologic treatments used for depression, bipolar disorders, anxiety disorders, eating disorders, and psychosis. Considerations for the timely and appropriate referral for psychiatric intervention for women with psychiatric or pharmacologic emergencies are discussed, and issues relating to pregnancy, lactation, and reproductive health are included. The importance of the nurse-midwife's role in ensuring women's access to and compliance with psychopharmacologic therapy is emphasized.

Emergencies↗
PubMedDate not supplied

Queen Elizabeth Behavioural Assessment Graphical System.

The Queen Elizabeth Behavioural Assessment Graphical Scale (QEBAGS) is presented as a new, descriptive rating method for documenting behavioural disturbances in a variety of clinical settings. The scale utilises three categories of behavioural disturbances which may occur in isolation or may co-exist. These are documented on a graphical plot across a 24 hours' time span. Neither diagnostic information nor severity of a particular behavioural disturbance needs to be interpreted before a rating on each parameter can be made, thus allowing its use by any intelligent observer, including a carer at home. Documenting of behavioural disturbance across day and night, by intermittent or regular observations, provides valuable information on the time, course and pattern of behavioural disturbance, from which diagnostic and therapeutic directions can be inferred. In preliminary clinical use, the scale has improved documentation of behavioural disturbance and communication between health professionals about such behaviour and its management. The scale also has the potential to provide supportive documentation for the Resident Classification Index in Nursing Homes and Personal Care Assessment Index in Hostels. The scale is most effective in situations where moderate to severe disturbance of behaviour is present. Where there is little or no disturbance, the system is unlikely to be of benefit. Clinical examples of its utility are presented.

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