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Biomedical subjects

C Chopin

Publications and source records attributed to C Chopin.

At least 91 records · Page 5Linked to original sources
PubMed1980

Acute intoxication with diisopyramide: clinical and experimental study by hemoperfusion an Amberlite XAD 4 resin.

Diisopyramide overdose induces an early and severe cardiogenic shock; hemoperfusion on resin (Amberlite XAD 4) is the most efficient treatment. In vitro, 92% of the drug is adsorbed in 240 min. In dog, the plasmatic epuration is 66% with a mean plasma clearance of 74% plasmatic flow. A woman who had absorbed 4.50 g diisopyramide showed an idioventricular rhythm. The cardiac electrical stimulation and positive inotrope drugs were inefficient. Hemoperfusion on resin Amberlite XAD 4 corrected hemodynamic and ECG disturbances in 4 h. The epuration was proved by the decrease of diisopyramide plasma level: 24.4 micrograms/mL before epuration, 1.9 micrograms/mL after epuration, and a mean plasma clearance of 107.8 mL/min (61% of the plasmatic flow). Hemoperfusion of resin (Amberlite XAD 4) is more efficient than hemodialysis (cuprophan) and hemofiltration (polyacrylonitrile). The system that we have used is well tolerated and of low cost.

Animals↗
PubMed1979

[A case of acute acrolein poisoning].

A four and a half year old boy was hospitalised with acute respiratory failure due to the inhalation during two hours of the smoke from an overheated frier. Oxygen, corticosteroids and furosemide led to clinical stabilisation but after 24 hours asphyxia developed. The trachea was found to be obstructed by a firm elastic substance which prevented intubation or bronchoscopy. Autopsy revealed massive cellular desquamation of the bronchial lining. The lumen was occupied by miscellaneous debris. There were multiple pulmonary infarcts. This is the second case of acute intoxication by acroleine. In the light of these two cases, treatment should consist of corticosteroids, antibiotherapy, inhalation therapy, and repeated bronchial aspiration.

Acrolein↗
PubMed1979

[Definition and realization of a microprocessor system for monitoring during artificial ventilation (author's transl)].

A medical application of a microprocessor system is presented. The definition of a system able to control the quality of the respiratory exchanges for a patient submitted to artificial ventilation is given. The measurement system is composed by two rapid analysers of CO2 and O2 (Beckman LB2 and OM 11), a flow meter devices and an airway pressure sensor (Monaghan M 700). The monitoring of the ventilation is based on the determination of FAECO2 simultaneous the determination of FECO2, FIO2, FEO2 and FAEO2 allow, with the sequential entries of the blood gaz values, to calculate: VA/V, D (a--A) CO2, D (A--a) O2, VO2, VCO2 and respiratory quotient. Now, we are working out a system composed by: a microprocessor (Intel 8080) which allows acquisition and treatment of the signals; a peripherical with a key board for the dialogue between the operator and the system; a visual display unit and a printer. Measurements are made on the patient every 13 mn during five respiratory cycles. All the stated above parameters are then computed. When there is a variation of FAECO2, an alarm is triggered, of predeterminated threshold is exceeded. This system simple, not too expensive, not invasive, has been conceived to work on one to four patients.

Carbon Dioxide↗
PubMed1978

[Rhabdomyolysis in acute intoxications (author's transl)].

During acute intoxications rhabdomyolysis appear with a great clinical polymorphism. The muscular involvement is not always evident because of its shortness and latence. Practically the problem is one of localised muscle damage, hyperkaliema or acute renal insufficiency. The serum isoenzymes of CPK levels, the presence of myoglobinuria are necessary for the diagnosis. The most serious rhabdomyolysis depend on the added injury of respiratory muscles and myocardium. Many toxic substances can involve rhabdomyolysis but the most frequent ones are sedatives, carbonic oxyde, ethanol. Only the complications are treated.

Alcoholic Intoxication↗
PubMed1978

[Meadows syndrome. A case history (author's transl)].

The authors, having studied a case of Meadows syndrome, confirm that this cardiomyopathy is a specific entity in pregnancy and the puerperium. They point out the difficulties in diagnosis, as Meadows syndrome seems to be diagnosis of elimination. They point out that a paraclinical balance has to be drawn up very fully on the biological and haemodynamic planes to confirm this condition. Finally, after a short discussion about the therapy, they tackle the problem of the prognosis for life and for future childbearing in these patients, which is determined by the persistence or absence of cardiac enlargement.

Adult↗
PubMed1977

[Current aspects of gas gangrene, apropos of 47 cases collected over a 3-year period (1974-1976)].

On the basis of 47 cases of gas gangrene collected over the three year period between 1974 and 1976, the authors review the circumstances surrounding its development, the clinical features and the prognosis of the disorder which remains grave despite a well-defined therapeutic protocol combining surgery, antibiotics and hyperbaric oxygen. There would appear to be a real resurgence of the disease at the present time. Post-traumatic and surgical aetiologies predominate, giving rise to two types of gangrene: clostridial gas gangrene secondary to contamined wounds, with a quasi-constant vascular element, affecting predominantly the limbs, and nonclostridrial gangrene, the increasing prevalence of which involves essentially spetic abdomino-pelvic surgery. In the light of this study, prognosis would appear to be related to the underlying terrain in which the gangrene occurs, to certain features of the clinical picture and, above all, to the possibilities of early application of the complete therapeutic protocol. Strict prophylactic measures would alone seem capable of preventign the worrying increase in the number of cases of gas gangrene.

Adult↗
PubMed1977

[Determination of global diffusion of CO2 and its partial components under assisted respiration. Technical problems and practical value in respiratory resuscitation].

A study of partial CO2 ductance has been performed in patients under assisted ventilation. The authors propose methods for simultaneous measurement of paCO2, PAECO2, PECO2 and PICO2. This methodology is used in patients presenting different conditions accounting for respiratory resuscitation: barbiturate poisoning with healthy lungs, bronchial stasis, acute lung involvement, obstructive bronchopneumopathy and pulmonary embolism.

Carbon Dioxide↗