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Biomedical subjects

C Childs

Publications and source records attributed to C Childs.

41 records · Page 3Linked to original sources
PubMed1988

Fever in burned children.

The patterns of rectal temperature (Tr) and skin surface temperatures (Tthigh and Ttoe) of 40 children were studied during the first 48 h after burn injury. The patients' ages ranged from 5 months to 12 years and all required intravenous resuscitation. On admission Tr measured 2-6h after the burn, ranged from 36.5 to 39.0 degrees C and 19 children had temperatures greater than 37.5 degrees C; the upper limit of the normal range for healthy children. Patients 5-12 months old had the lowest Tr during the early period. During the first 12 h Tr rose rapidly and 27 patients (67 per cent) had a fever (Tr greater than 38.5 degrees C). In 10 children Tr was greater than 40.0 degrees C. There was no relationship between the rise in Tr and the sex of the patient, the ambient temperature, the size, site or type of burn. Age was the most important variable, particularly during the first 12 h, where a positive correlation between Tr and age occurred in patients aged 5-23 months (P less than 0.01, r = 0.53). Throughout the first 48 h Tr remained elevated. Tthigh closely followed the pattern of Tr, but Ttoe varied considerably, reflecting cardiovascular as well as thermoregulatory responses.

Body Temperature Regulation↗
PubMed1988

Phenotypic and molecular heterogeneity in Philadelphia chromosome-positive acute leukemia.

Philadelphia chromosome-positive (Ph1) acute leukemia is a heterogeneous subset of acute leukemia with a poor prognosis. We studied five patients to determine the potential for phenotypic and molecular heterogeneity. Cellular characterization studies included light myeloperoxidase (L-MPO), terminal deoxynucleotidyl transferase (TdT), ultrastructural MPO (U-MPO), and immunophenotyping by flow cytometry using T11, T3, T4, T8, Leu 1, B1, Leu 12, HLA-DR (la), CALLA (J5), OKM1, My4, My7, My8, My9, and My10. DNA was analyzed for rearrangements of the breakpoint cluster region (bcr), immunoglobulin heavy chain, joining region (JH), immunoglobulin kappa light chain constant region (C kappa), and T cell receptor (TcR beta). RNA dot blots were hybridized by using molecular probes for MPO and TdT. We found that four of five cases were acute mixed-lineage leukemia (AMLL). One patient had acute unclassifiable leukemia. Of the four patients classified as having AMLL, three showed myeloid and lymphoid features, with one patient showing myeloid, T cell, and B cell features. The last case showed T cell and B cell features only. In one patient MPO/RNA was positive in spite of insufficient L-MPO or U-MPO to diagnose acute myelogenous leukemia (AML), thereby suggesting significant MPO gene expression before the production of sufficient MPO protein to meet the French-American-British criteria for AML. Three of the five patients showed rearrangement of bcr (cases 1, 2, and 5). Studies of these five patients support the concepts of molecular and phenotypic heterogeneity in Ph1 acute leukemia, demonstrate a high incidence of AMLL in this subset of acute leukemia, and support the use of lineage-associated molecular probes to define lineage at an earlier stage than previously possible.

Acute Disease↗
PubMed1985

Carcinoma of prostate metastatic to penis.

A case report of prostatic carcinoma metastasizing to the penis is presented. Review of the literature revealed only 54 cases reported to date. With survival rates ranging from two to six months, the prognosis is gloomy. The most commonly used method of treatment was local wide excision of the lesion.

Acid Phosphatase↗
PubMed1982

Histochemical study of Hurler's disease by the use of peroxidase-labelled lectins.

Peroxidase-labelled lectins specific for various carbohydrate residues were used as histochemical reagents in the investigation of Hurler's syndrome. Peanut lectin was used to detect terminal D-galactose, wheatgerm lectin for N-acetyl-D-glucosamine, soybean lectin for N-acetyl-D-galactosamine, Tetragonolobus lotus lectin for alpha-L-fucose and Bandeiraea S. lectin for alpha-D-galactose. It was found that Kupffer cells in the liver and splenic reticulo-endothelial cells contain acid mucopolysaccharides which bind lectins in paraffin sections after appropriate fixation. The pattern of lectin binding suggests that such cells contain significant amounts of D-galactose, L-fucose, N-acetyl-D-galactosamine and N-acetyl-D-glucosamine. It is likely that the last named carbohydrate is present as a polymer. Neurones contain a different carbohydrate, rich in galactose and fucose but poor in N-acetyl-D-glucosamine. This compound is resident to lipid extraction. Hepatocytes, as a rule, do not react with lectins, most likely because of loss of the more soluble mucopolysaccharides during fixation. The results are consistent with the biochemical data of Hurler's syndrome and indicate that lectins can be a useful tool for the investigation of the cytochemistry of storage disorders.

Child↗