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Biomedical subjects

C Chidiac

Publications and source records attributed to C Chidiac.

81 records · Page 5Linked to original sources
PubMed1989

[Treatment of pneumonia caused by Legionella, Mycoplasma, Chlamydiae and Rickettsia using ofloxacin].

To asses the efficacy and the safety of ofloxacin as therapy of pneumonia caused by intracellular pathogens, 35 patients were studied (26 male, 9 female, mean age: 52.5 +/- 16.6 years). Causative pathogens were Chlamydia psittaci (n = 13), Legionella pneumophila (n = 10), Mycoplasma pneumoniae (n = 7) and Coxiella burnetii (n = 5). Ofloxacin was administered orally in 32 cases (200 mg b.i.d. in 80% of cases) and by I.V. route in 3 cases. All patients were cured without any side effects. In conclusion, ofloxacin appears, in our study, as an efficient therapy for these pneumonias. It could be considered as a valuable alternative to other antimicrobial agents with intra-cellular activity.

Adult↗
PubMed1989

[Contribution of experimental models to the treatment of respiratory tract infections].

The need for more effective and potentially less toxic antimicrobial agents than aminoglycosides for treatment of gram negative bacilli pneumonia specially Pseudomonas aeruginosa, explains the interest for experimental models of pneumonia. These models allow to study the efficacy and safety of antibiotics alone or in combination. Aminoglycosides and new quinolones are more effective than beta-lactams for life threatening infection with high inoculum, the only exception to this finding has been for N-formimidoyl thienamycin, whereas for less severe infections aminoglycosides and beta-lactams are equivalent in efficacy. In contrast to high inocula pneumonia, combining beta-lactams with aminoglycosides give additive of synergic benefits for treating low inocula. Experimental models allow to compare continuous versus intermittent administration of antibiotics, different regimens of the same antibiotics (single daily dose of aminoglycosides versus conventional administration) and new antiinfectious agents as anti-pseudomonas hyperimmune globulins.

4-Quinolones↗
PubMed1988

[Pulmonary valve endocarditis caused by Streptococcus D bovis in a patient with a colorectal adenocarcinoma].

A case of pulmonary endocarditis caused by Streptococcus D bovis in a female patient with colorectal adenocarcinoma is reported. The M-mode and two-dimensional echocardiographic and pulsed doppler ultrasound findings are described. A review of the literature shows that Streptococcus D bovis pulmonary endocarditis is rare. Any septicaemia or endocarditis caused by this organism calls for invasive exploration of the digestive tract, and especially the colon.

Adenocarcinoma↗
PubMed1986

[Difficult diagnosis of the plasmodial species].

We reported a case of malaria in a 37 years-old French woman. The first crisis occurred 8 months after coming back from an endemic area. Plasmodium falciparum was the responsible species. After 3 months' clinical latence, the patient had a new malarial crisis, but P. vivax malaria. Pictures of polyparasitism and the almost total absence of Schüffner granulations were noted. This double malaria infection and the involvement of atypical plasmodial strains are discussed.

Adult↗