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Biomedical subjects

C Chatelain

Publications and source records attributed to C Chatelain.

At least 145 records · Page 8Linked to original sources
PubMed1983

Lithium enhancement of megakaryocytopoiesis in culture: mediation via accessory marrow cells.

To examine the effect of lithium (Li) on early megakaryocytopoiesis, murine marrow megakaryocytic (CFU-M) and granulocyte-macrophage (CFU-C) progenitors were assayed in vitro with and without addition of lithium chloride (LiCl) to culture. At 2 mM LiCl, the numbers of CFU-M- and CFU-C-derived colonies were increased to 146% +/- 8% and 128% +/- 6% of controls, respectively (p less than 0.005). Enumeration of megakaryocytes per colony showed a 78% increase of colonies (p less than 0.05) containing from 6 to 22 cells, suggesting an increased proliferative capacity of CFU-M in the presence of LiCl. Conditioned media from spleen cells cultured in the presence of both pokeweed mitogen (PWM-SCM) and 2 mM Li increased the numbers of CFU-M and CFU-C to 157% +/- 8% and 183% +/- 8%, respectively (p less than 0.025), compared to control cultures stimulated by PWM-SCM alone. Since the production of active colony-stimulating activities (CSA) from mitogen-stimulated conditioned media requires T lymphocytes, we hypothesized that the enhancement of the growth of early hematopoietic progenitors in marrow cultures was due to a Li-induced CSA production by accessory marrow cells, rather than a direct effect of Li on stem cells. To test this, cyclosporin-A (CyA), a T-lymphocyte function inhibitor known to suppress CSA production in PWM-SCM, was added to marrow cultures in the presence of 2 mM Li. CyA (3 micrograms/ml) abrogated the Li-induced enhancement of CFU-M and CFU-C growth, but had no effect on colony formation when added alone. The data suggest that the Li-induced enhancement of early megakaryocytopoiesis and granulocytopoiesis is due to local production of CSA(s) by an accessory cell population and requires the integrity of T-lymphocyte function.

Animals↗
PubMed1982

[Bladder sphincter disorders in multiple sclerosis: symptomatology and evolution. 100 cases].

The semiology and evolution of vesicosphincteral disorders have been studied in a series of 100 cases of multiple sclerosis. All the patients underwent a complete checkup and were followed over a period of 6 years. Mictional problems appear within the first five years in 60 p. cent of cases. When they occur later on, they tend to follow the evolution of the disease on their own. There exist regular correlations between the gravity of the motor and sphincteral handicap, and between the size of the postmictional residue (over 20 p. cent of the miction), the time elapsing since the onset of the mictional disorders, and the appearance of uronephrological complications.

Enuresis↗
PubMed1982

[Malignant adrenal cortical tumors. 9 cases].

Nine cases of malignant adrenal cortical tumour treated during the last decade are reported. As in many other series, these rare tumours were predominant on the left side (7/9) and affected mainly adult females (6/!) with a mean age of 44 years. The 8 secretory tumours were revealed by their hormonal effects: endocrine syndrome or arterial hypertension. The single, clinically non-secretory tumour presented as a palpable mass. The most common findings of hormonal exploration undertaken in 8 of the 9 patients were abolition of the cortisol nycthemeral cycle and non-response to dynamic tests. In 8 cases the tumour was demonstrated by intravenous urography, but its location and extension were best shown by CT scans. Two scintigraphies performed with labelled iodocholesterol were positive. All patients underwent complete excision of the tumour: 5 out of 9 had hepatic metastases at the time of surgery. The median survival of the 7 patients who died was 13 months; 6 of these had received Op'DDD (mitotane) post-operatively. Two patients, including one treated with Op'DDD, are still alive after 18 and 32 months respectively, without signs of recurrence.

Adrenal Cortex Neoplasms↗
PubMed1982

[The immediate and remote results of surgical treatment of renal adenocarcinomas. Discussion of two hundred and twenty-two cases (author's transl)].

A series of 222 cases of adenocarcinoma of the kidney are discussed. Many of these cases involved extended carcinomas (stages III and IV, 65 p. cent; stage IV, 41 p cent). The surgical procedures used included 204 extended nephrectomies, 4 partial nephrectomies and 14 laparotomies for the exploration of unextirpable cancers. The mortality rate was 4.5 p. cent and the morbidity rate, 22 p. cent. 168 patients were followed up over a long period after an extended nephrectomy (8 died postoperatively and contact was lost with 28 patients after their operations). The 5-year survival rate was 71 p. cent for stage I, 77 p. cent for stage II, 48 p. cent for stage III and 23 p. cent for stage IV.

Adenocarcinoma↗
PubMed1981

[Results of one year (1978) of kidney transplantation (author's transl)].

Kidney transplantation in France is not as common as both patients and health authorities would wish. While at least 1 000 transplantations would be required each year, only 550 were done in 1978. The authors report on the experience of a team which for the first time was able to perform 75 transplantations in one year, and bring to the pull of transplantation 74 cadaver kidneys. The 75 patients will be followed up by the same group which operated upon them not only during the post-operative period, but also for many years to come. As far as possible, the team endeavours to transplant kidneys from local donors or sent directly to the surgeons. Such a "regionalisation" of kidney transplantations suffers from the drawback of lesser compatibility, but makes it possible to obtain the expected results.

Adolescent↗
PubMed1981

Endoscopic internal urethrotomy for treatment of urethral strictures: midterm survey.

Success in the management of urethral strictures can be claimed only after many years, patients sometimes faring well for ten years or more before suffering a recurrence. We used endoscopic urethrotomy as primary treatment for a variety of urethral strictures in 123 patients. Follow-up is over two years for 63 patients and more than five years for 18. Over-all success rate at five years was 76 per cent. Failures are twice as frequent in strictures, regardless of their origin, involving the anterior urethra than in the bulbar or posterior urethra. Two-thirds occurred in the first year of follow-up, but, as in other techniques, recurrence can occur after four years.

Adolescent↗
PubMed1980

Diagnosis and treatment of renal angiomyolipoma (based on 15 cases). Arguments in favor of conservative surgery (based on 8 cases).

Angiomyolipoma should be suspected when a renal tumor is present especially when the patient is young, the tumor is bilateral, associated with hemorrhagic incidents or if there are multiple tumors in one kidney. When tuberous sclerosis is present the diagnosis is easier and when it is not, arteriography and tomodensitometry are of great help. The benign nature of these tumors is not an argument in favor of nonsurgical treatment. They may sometimes be associated with an authentic malignancy which underlines the necessity of confirming the diagnosis by peroperative examination of a frozen section. When angiomyolipoma is confirmed the surgical treatment of this benign tumor should, in our opinion, be conservative considering the frequency of bilateral disease. This approach is supported by the results published and by our own 8 cases treated by conservative surgery.

Adult↗