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Biomedical subjects

C Chaponnier

Publications and source records attributed to C Chaponnier.

59 records · Page 4Linked to original sources
PubMed1978

Cytoplasmic filaments and gap junctions in epithelial cells and myofibroblasts during wound healing.

During the healing of an experimental skin wound, epidermal cells and granulation tissue fibroblasts (myofibroblasts) develop an extensive cytoplasmic contactile apparatus. Concurrently, the proportion of epidermal cell surface occupied by gap junctions increases when compared to normal skin, and newly formed gap junctions appear between myofibroblasts; this suggests that epidermal cell migration and granulation tissue contraction are synchronized phenomena.

Animals↗
PubMed1977

Fixation of human anti-actin autoantibodies on skeletal muscle fibres.

Sera from five patients with chronic aggressive hepatitis containing smooth muscle autoantibodies were tested by means of indirect immunofluorescence for their binding to isolated rabbit skeletal muscle myofibrils. In all cases, the immunofluorescent staining was sharply localized to I bands. After incubation of these sera with skeletal muscle troponin-torpomyosin complex, purified troponin or purified tropomyosin, no changes in immunofluorescent staining of myofibrils were noted. However, the staining was abolished after incubation of the sera with skeletal muscle actin. In double immunodiffusion experiments, a single precipitation line was obtained after diffusion of the sera against crude or purified actin. It is concluded that, at least for the sera examined, smooth muscle autoantibodies are anti-actin autoantibodies. The high titre of such autoantibodies and their availability in clinical immunology laboratories make them a useful tool to study actin distribution in muscular and non-muscular cells.

Actins↗
PubMed1975

Actin in the cytoplasm of adrenocortical cells.

Rat or hamster adrenocortical cells contain a network of filaments mostly 40-80 A in diameter, which is particularly evident at the cell periphery. In frozen sections, adrenocortical cells fix (particularly at their periphery) anti-actin autoantibodies present in sera of patients with chronic aggressive hepatitis. It is concluded that the peripheral network of adrenocortical cells contains contractile proteins (at least actin) and the implication of such proteins in steroid secretion is discussed.

Actins↗