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Biomedical subjects

C Cavallotti

Publications and source records attributed to C Cavallotti.

168 records · Page 10Linked to original sources

Effect of dopamine on the cyclic adenosine monophosphate generating system in the rabbit internal carotid and middle cerebral artery.

The effect of in vitro addition of dopamine on the 3'-5'-cyclic adenosine monophosphate (cAMP) generating system of rabbit internal carotid and middle cerebral artery was studied. Dopamine increased cAMP levels in a dose-dependent manner in both arteries. The DA1-receptor antagonist SCH 23390 decreased the dopamine-elicited cAMP increase. On the contrary, the DA2-receptor antagonist L-sulpiride caused an increase in dopamine-dependent cAMP levels. The simultaneous addition of SCH 23390 and of L-sulpiride abolished any effect of dopamine on cAMP content. The DA2-receptor agonists bromocriptine and co-dergocrine decreased cAMP levels. The above findings indicate the existence in the rabbit internal carotid and middle cerebral artery of 2 types of dopamine receptors mediating respectively, the increase (DA1-effect) and the decrease (DA2-effect) of cAMP levels.

Animals↗

Autoradiographic localization of the dopaminergic agonist 3H-dihydroergotoxine within the male reproductive system.

By the use of combined radioreceptor binding and autoradiographic techniques, we analyzed the anatomical localization of the dopaminergic agonist 3H-dihydroergotoxine in tissue sections of rat male sex organs. The drug was bound by smooth muscle cells of the deferent duct, seminal vesicles and prostate gland as well as by the glandular tissue of seminal vesicles and prostate gland. These data allow us to hypothesize that the effect of dopaminergic agonists on male sexual function may be due, at least in part, to a direct interaction with dopamine receptors present in the reproductive organs.

Animals↗

[Anterior communicating artery: morphologic and structural aspects].

The gross anatomy of the anterior communicating artery has been studied in 40 adult brains removed at autopsy. We have observed 6 different anatomicals variant of the artery. A histological study shows that the wall of the artery is constituted with three layers: intima, media and adventitia. Moreover the structure of the arterial wall is different in some anatomicals variant. The findings are discussed.

Adult↗