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Biomedical subjects

C Casey

Publications and source records attributed to C Casey.

40 records · Page 3Linked to original sources
PubMedDate not supplied

Reverse zymography studies of protease inhibitors in the secretions of different lobes of rat prostate.

The purpose of this study was to determine whether protease inhibitors were a constituent of secretions from the different lobes of the rat prostate. A reverse zymography method was used employing gelatin substrate-SDS-polyacrylamide gel electrophoresis to detect inhibitors of trypsin in secretions of the ventral, lateral, and dorsal prostate lobes of the Sprague-Dawley rat. Inhibitors of approximately 34 and 63 kDa were detected in ventral prostate secretion and of about 63 and 73 kDa were found in lateral lobe secretion. However, no inhibitor activities were detected in secretions of the dorsal lobe. The protease inhibitors of ventral prostate secretion were partially purified by preparatory isolectric focusing and SDS-polyacrylamide gel electrophoresis. The 34-kDa (pI 5.6-6.4) inhibitor had a higher activity against trypsin, whereas the 63-kDa (pI 6.4-7.0) inhibitor was more active against chymotrypsin. The rat prostate appears to have a lobe-specific distribution of secretory serine protease inhibitors.

Animals↗
PubMedDate not supplied

The incidence of postnatal depression in a rural area and the needs of affected women.

The Gippsland Maternal and Child Health Service Research Group conducted a survey to investigate the incidence of postnatal depression in women with three months old infants who were born in the Gippsland region. As well, the mothers were asked how they could have been better supported in the five to 13 weeks after their babies were born. The respondents' Edinburgh Postnatal Depression Scale scores indicated that 58% of women had experienced depression. These women expressed a need and a preference for home based support, i.e. occasional child care, extended home help, greater access to telephone counselling and home visits by maternal and child health nurses and for education of their infants' fathers. On the basis of the study and their experiences, the Research Group makes recommendations about how the needs of women with postnatal depression may be better met.

Depressive Disorder↗