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Biomedical subjects

C Carson

Publications and source records attributed to C Carson.

29 records · Page 2Linked to original sources
PubMedDate not supplied

Premature ejaculation: definition and prevalence.

Premature ejaculation (PE) is likely the most common sexual dysfunction in men, with a worldwide prevalence of approximately 30%. To date, the lack of a universally acknowledged definition of PE has complicated the examination and analysis of PE in clinical and research-related settings. The impact of PE on men and their partners also needs to be clearly defined. Clearly, a better understanding of the epidemiology of this disorder, especially with regard to prevalence and risk factors, is necessary. The prevalence of PE appears to vary across socio-cultural and geographic populations. The elucidation of the etiology of PE and risk factors associated with PE has been difficult. However, several risk factors for PE exist that have strong support in the literature. Clearly, an improved and universal definition and understanding of PE and its epidemiology will improve the clinical management of PE and the success of future epidemiologic studies and clinical trials.

Clinical Trials as Topic↗
PubMedDate not supplied

Degradation of constitutive transcription factors during apoptosis in rat thymocytes.

Dexamethasone (Dex) accelerates the rate of apoptosis in thymocytes by a process thought to require gene expression. Among the genes implicated in the regulation of this phenomenon are the immediate early genes such as c-fos and c-jun, whose expression is modulated by a complement of preexisting transcription factors. We have analyzed the DNA-binding activity of these constitutive transcription factors during Dex-induced apoptosis in thymocytes to assess their functionality. We observed a progressive loss of the DNA-binding proteins in parallel with the appearance of the characteristic morphological and biochemical features of apoptosis. At the same time we have found a general increase in the nuclear proteolytic activity concomitant with a significant loss of the nuclear nonhistone chromosomal proteins. Indeed, cotreatment of thymocytes with the nonspecific serine protease inhibitor phenylmethylsulphonyl fluoride was able to partially protect the stability of the DNA-binding proteins and alter the expression of the c-fos and c-jun genes but did not inhibit apoptosis. Our results suggest that the action of a protease(s) is responsible for the degradation of constitutive transcription factors during Dex-induced apoptosis, rendering the death pathway irreversible.

Animals↗
PubMedDate not supplied

Mental illness: support for relatives.

A questionnaire-based evaluation of a support group for relatives of people with mental illness living in the community is described. Set up initially in 1987, the evaluation suggests that the group has succeeded in offering emotional support to most members, although others have ceased to attend. The authors recommend that regular support of carers should become an integrated part of community mental health services.

Anger↗
PubMedDate not supplied

A diabetic service for adolescents.

Lothian provides a personalized service to adolescents with diabetes in which the DNSA plays a unique and pivotal role. The service is expensive in terms of the time it requires, but it is hoped that both the patients and the service will reap the benefits in years to come with healthier patients, less complications, reduced intervention and less expensive treatments.

Adolescent↗