Inhibition of in vitro autosensitization by a thymic humoral factor.
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Biomedical subjects
C Carnaud
Publications and source records attributed to C Carnaud.
In vitro cytotoxicity and in vivo tumor enhancement induced by mouse spleen cells autosensitized in vitro.
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[Mathematical study of the kinetics of radiocesium in the ewe].
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[H-2 specificity and auto-reactivity of autologous rosette-forming cells from adult thymectomized mice spleen cells].
We have previously shown that the number of autologous rosette-forming cells (A-RFC) found in adult thymectomized mice (A-Tx) spleens was 15 times higher than that found in spleens of intact controls. We have therefore investigated both the specificity of A-RFC and their relationship with autoreactivity. Immunoadsorption experiments showed that while the incubation on allogeneic monolayers did not bring any modification in A-RFC levels. This result suggests that the formation of autologous rosettes is the manifestation of a true recognition event associated with the H-2 complex. A-Tx mice spleen cells injected into syngeneic recipients induced an enlargement of the afferent popliteal lymph node (LN). Ficoll-Triosil A-RFC depleted A-Tx spleen cells lost their capacity to induce this popliteal proliferation. Conversely, A-RFC recovered spleen cell suspensions obtained from the pellet of the Ficoll Triosil gradient kept their capacity of inducing auto-reactivity. Thus, it seems that A-RFC and lymphocytes stimulating the afferent LN belong to the same sub-population.
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