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Biomedical subjects

C Capesius

Publications and source records attributed to C Capesius.

27 records · Page 2Linked to original sources
PubMed1990

[Adrenal pheochromocytoma. Current aspects of diagnosis and treatment].

Since 1984, 5 patients with pheochromocytoma were operated in our department. Diagnosis was suspected by clinical findings and symptoms, and confirmed by measuring catecholamines and metabolites in 24 hours urine specimen. CT Scan located all the tumors. Iodine 131-MIBG confirmed the diagnosis and the location since it was used for the last three cases. Patients were prepared with alpha-blockade with or without beta-blockade. Volume expansion and monitoring with Swan-Ganz catheter was performed 24 hours before the operation. The surgical approaches were: anterior trans-abdominal once, thoraco-abdominal twice, and retro-peritoneal twice with less morbidity. We propose the following attitude when pheochromocytoma is suspected: 1. 24 hours urine catecholamines and metabolites, 2. CT-Scan and RMN if available, 3. Iodine 131-MIBG scintigraphy, 4. Pre-operative alpha-blockade associated with beta-blockade if necessary, 5. Retro-peritoneal approach for the uni-lateral adrenal pheochromocytoma.

Adrenal Gland Neoplasms↗
PubMed1980

[Lymphocytic infiltrations of the nipple. The benign cutaneous lymphocytoma of the breast areola (author's transl)].

Benign lymphocytic infiltrations may often occur in the skin of nipple and areola: 55 cases have been described in literature especially in Scandinavia and in Germany, sometimes in correlation with tick bites or erythema chronicum migrans, but until now no cases have been reported in France. In a retrospective study of 30 cutaneous lymphocytomas, we found 8 cases localized on the breast-3 children and 5 older patients-, associated with a erythema chronicum migrans in 3 patients and following a tick bite in another patient. The course of the disease is always benign and the healing can be accelerated by penicillin therapy. The pathogenesis still remains unclear but some data argue for an infectious mechanism: frequency of tick bites (20 p. 10), geographical occurrence in the spreading area of common ticks in Europe, affinity of ticks for the breast in all mammals, carriage of viruses by some tick species, efficiency of penicillin in tick-transmitted viral infectious and in benign skin lymphocytomas, positive inoculations in volunteers, general course of an infectious disease (seasonal variations, frequency of satellite lymph-node swelling, spontaneous healing).

Aged↗
PubMedDate not supplied

Oesophageal intraepithelial and invasive neoplasia of squamous cell type: epidemiology and outcome in Luxembourg, 1980-2001.

BACKGROUND AND STUDY AIMS: Oesophageal intraepithelial neoplasia of squamous cell type (INSC) and invasive oesophageal squamous cell carcinoma (IOSCC) are infrequent diseases in Western Europe. The aim of the present study was to collect population-based data of both entities over a 20 year-period and to look for concomitant neoplastic affections in order to define an adequate diagnostic strategy. PATIENTS AND METHODS: The National Morphologic Tumour Registry allowed to review the data of all patients with INSC and IOSCC diagnosed between 1980 and 2001 and to record the time trends in incidence, the oncologic co-morbidity and the outcome of the patients. RESULTS: 29 patients with INSC and 363 cases of IOSCC were identified. The overall age-standardized (world) incidence rate of intraepithelial neoplasia and invasive squamous cell carcinoma were 0.2 and 4.2 per 10(5), respectively, the M/F-ratio for both 3:1. During the study period, the incidence rate of invasive cancer remained stable in males but showed a 3-fold increase in females. There was a 2-fold increase of the intraepithelial neoplasia incidence in the last decade. The precancerous/cancerous-ratio increased slightly over the last 5 years. 31% of the patients with an INSC and 17.6% of those with IOSCC had concomitant precancerous and cancerous lesions especially of head and neck (laryngopharyngeal) or pulmonary origin. The observed 5-year survival rate was 8.8 +/- 3% (95% confidence interval) for IOSCC and 27.6% +/- 17% for INSC. CONCLUSIONS: The incidence of invasive oesophageal squamous cell carcinomas remains stable whereas that of detected intraepithelial squamous cell neoplasias is remarkably low, indicating potential underdiagnosis. Considering the overall low incidence rates, mass screening for oesophageal cancer does not seem reasonable in Luxembourg. Nevertheless, patients at high-risk for oesophageal or head and neck or broncho-pulmonary cancer should be identified and surveilled by endoscopy, possibly with vital staining.

Adult↗
PubMedDate not supplied

[The value of anorectal sphincteromyectomy for the diagnosis and treatment of chronic constipation in children].

From January 1974 till the end of 1981, 105 children with chronic constipation not responding to any medical treatment, were submitted to anorectal myomectomy. This operation has both a diagnostic and a therapeutic value; the histological study of the muscle biopsy can confirm or not a Hirschsprung's disease. It is also an ideal treatment in cases of achalasia and idiopathic chronic constipation. If necessary a secondary rectosigmoidectomy can be performed. We did not have any important complication, none of our patients had soiling. Eighty-eight percent of our patients had regular bowel movements after the anorectal myomectomy with a better individual, social and family life.

Adolescent↗