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C Cao

Publications and source records attributed to C Cao.

129 records · Page 8Linked to original sources
PubMedDate not supplied

Topological indices based on vertex, distance, and ring: on the boiling points of paraffins and cycloalkanes.

Vertex, distance, and ring (in cyclic compounds) are three essential structure elements of a molecular graph, based on which three new topological indices VDI, OEI, and RDI are proposed. Multiple regression analysis was carried out against the boiling points of 343 hydrocarbons(160 paraffins and 183 cycloalkanes) with VDI, OEI, RDI, and N(2/3)(N is the number of carbon atoms) together, and a good QSPR model was obtained: ln(577 - Bp) = 6.729609 - 0.154107N(2/3) + 2.285632 x 10(-2)VDI - 7.921410 x 10(-3)OEI - 1.821962 x 10(-2)RDI (F = 6455.09, r = 0.9935, rms = 6.44 degrees C, n = 343).

Journal Article↗
PubMedDate not supplied

Retrospective analysis of varicella zoster virus (VZV) copy DNA numbers in plasma of immunocompetent patients with herpes zoster, of immunocompromised patients with disseminated VZV disease, and of asymptomatic solid organ transplant recipients.

BACKGROUND: Varicella zoster virus (VZV) causes significant morbidity and mortality in immunocompromised patients. Subclinical reactivation has been described in solid organ recipients and has been associated with graft versus host disease in bone marrow transplantation. Newer studies assessing the prevalence and impact of subclinical VZV reactivation in solid organ transplant (SOT) recipients are lacking. METHODS AND RESULTS: In a first step we developed a highly sensitive quantitative polymerase chain reaction (qPCR) assay for VZV DNA with a detection limit of < or = 20 copies/mL. Using this assay, we retrospectively analyzed plasma samples of different patient groups for VZV DNA. VZV DNA was found in 10/10 plasma samples of immunocompetent patients with herpes zoster (VZV copy numbers/mL: mean+/-SEM 1710+/-1018), in 1/1 sample of a human immunodeficiency virus-infected patient with primary VZV disease (15,192 copies/mL) and in 4/4 plasma samples of immunocompromised patients with visceral VZV disease (mean of first value 214,214+/-178,572). All 108 plasma samples of asymptomatic SOT recipients off any antiviral therapy, randomly sampled over 1 year, were negative for VZV DNA. CONCLUSION: Our qPCR assay proved to be highly sensitive (100%) in symptomatic VZV disease. We did not detect subclinical reactivation in asymptomatic SOT recipients during the first post-transplant year. Thus, subclinical VZV reactivation is either a rare event or does not exist. These data need to be confirmed in larger prospective trials.

Adult↗