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Biomedical subjects

C Campoy Folgoso

Publications and source records attributed to C Campoy Folgoso.

6 recordsLinked to original sources
PubMed2006

Organochlorine pesticides in serum and adipose tissue of pregnant women in Southern Spain giving birth by cesarean section.

Since the appearance of DDT, increasingly potent insecticides have been developed to overcome the resistance developed by insects to successive products. Pesticides are also used in public health programs to control disease vectors. Despite legislation to control the use of certain products, they repeatedly appear in the adipose tissue, milk and serum of human populations. The present study determined the presence of organochlorine molecules in the adipose tissue, serum, and umblical cord of women giving birth by cesarean section in order to establish a possible correlation in organochlorine molecule content between these biological compartments and to examine fetal exposure to molecules with hormonal effects. Presence of nine organochlorines was detected by GC/ECD and confirmed by GC/MS. Highly significant differences (p<0.000) were observed between adipose tissue and maternal serum in concentrations of lindane, HCB, DDE, DDD, and endosulfan but not (p>0.5) in concentrations of endosulfan II or endosulfan sulfate. Only DDE concentrations differed (p<0.001) between maternal serum and umbilical cord serum. An association between pp'DDE and op'DDT was observed in maternal serum (p<0.094). An association in pp'DDE and pp'DDD content was found between adipose tissue and umbilical cord serum, and in pp'DDT content between adipose tissue and maternal serum. Results obtained indicate that exposure can be measured solely in serum when relatively high concentrations of pesticides are present.

Adipose Tissue↗
PubMed1991

[Improving home auto-control in diabetic children: reducing atherogenic risk].

UNLABELLED: Insulin-dependent Diabetes (IDDM) is a major endocrine abnormality in children and the greatest morbi-mortality problems for diabetic patients are those related to cardiovascular complications (macro-microangiopaties), where kept hyperlipidemia and hyperglucemia play a fundamental patogenic role. The programs for optimization of home autocontrol have reduced frequent metabolic derangements. The aim of this study was to analyze the metabolic control state and its relationships with plasma lipids and atherogenic ratios in diabetic patients that were submitted to a program for optimization of home autocontrol of this illness. MATERIAL AND METHODS: Blood samples were taken fom 49 IDDM, aged 10.53 +/- 0.51 (+/- SEM) years old, with a mean evolution period of 4.34 +/- 0.38 years, at the begining of the program (Stage I) and 6 months later (Stage II). Biochemical Analysis: Total Cholesterol (TC), cholesterol joined to high density lipoprotein (HDLc), Triglycerides (TG) and Phospholipids (Ph) were measured by microspectrphotometric methods. Cholesterol joined to very low and low density lipoproteins (VLDLc and LDLc, respectively) were calculated by Friedwald's formula. Apoproteins A and B (Apo A and Apo B) were measured using Mancini's method, Glycemia levels (Gly) by peroxidase's method, Glycosilated Serum Protein (GSP) by colormetric's method and Glycosilated haemoglobine (HbA1c) by chromatographic separation using cationic interchange microcolumns. RESULTS: 65% of the patients showed a significant decrease in plasma levels of Gly, GSP and HbA1c percentage between Stages I and II (Favourable Metabolic Control).(ABSTRACT TRUNCATED AT 250 WORDS)

Arteriosclerosis↗
PubMed1990

[Estimation of the degree of metabolism-energy maturity in the premature newborn infant: plasma lipid profile and lipid transport systems].

The newborn preterm infant loses the opportunity to store energy as triacylglycerides form in the adipose tissue during the last quarter of gestation, so they have a real threat to maintain with exogenous supports only the high energy request, and they have been exposed to an elevated risk for central nervous system damage. Small reserves of substrates and poor metabolic adaptation may make the premature infant more vulnerable to the normal stresses of birth and the early postnatal period. We have studied the changes in plasma lipids profile and plasma lipoprotein cholesterol distribution in cord blood from 109 term newborn infants and 16 newborn infants have got higher plasma lipid concentrations than term newborn infants (total cholesterol: 76.81 +/- 4.67 mg/dl (mean +/- SEM) vs 66.72 +/- 1.54 mg/dl, p less than 0.02; Phospholipids: 136.00 +/- 5.24 mg/dl vs 113.94 +/- 2.86 mg/dl, p less than 0.005) and a different cholesterol lipoprotein distribution compared to normal full-term infants, standing out in premature babies, that cholesterol is essentially joint with low density lipoproteins (LDLc: 42.40 +/- 3.62 mg/dl vs 28.76 +/- 1.16 mg/dl, p less than 0.01). These results could be the expression of a metabolic-enzymatic fetal mechanism to keep up a good cholesterol and phospholipids biodisponibility to supply the structural tissues needs in this fetal stages of rapid growth and development.

Biological Transport↗
PubMed1990

[Effects of intra-partum stress on lipid metabolism. Adaptation of plasma lipid transport systems in neonates].

UNLABELLED: Intrapartum asphyxia modifies lipoprotein cholesterol distribution with possible repercussions related to membrane structures and its metabolic functions. We have studied plasma lipid profile and plasma lipoproteins cholesterol distribution in cord blood from 115 newborn infants and 72 pregnant women at delivery. RESULTS AND DISCUSSION: newborn infants with perinatal asphyxia (n, 48; pHua less than 7.20) have a higher cord blood triglyceridemia and lower plasma HDL-cholesterol, associated to high significant concentrations of atherogenic ratios (CT/HDLc, LDLc/HDLc) than normal newborn infants (n, 67; pHua = 7.20) [TG, 54.81 +/- 2.96 mg/dl vs 45.74 +/- 2.10 mg/dl (p less than 0.005); CT/HDLc, 24.00 +/- 1.30 mg/dl vs 29.62 +/- 1.12 mg/dl (p less than 0.05); LDLc/HDLc, 1.38 +/- 0.10 vs 1.07 +/- 0.06 (p less than 0.01)]. The highest triglycemia and atherogenic ratios in the acidotic newborn infants reveal deep changes in "esterified cholesterol/binding proteins" system, whereon "Apo A1-LCAT-Apo D" molecular complex binding HDL participate. More studies must be done to understand well this phenomenology. Furthermore, at delivery, pregnant women, that their newborn infants suffer an intrapartum hypoxia, had lower lipidemia than those who had newborn infants with intrapartum physiological stress.

Adaptation, Physiological↗