Biomedical subjects
Publications and source records attributed to C Camisa.
Erythromelalgia, characterized by temperature-dependent redness, pain, and warmth in one or more extremities, may be a primary disease or occur secondarily to underlying illnesses. Myeloproliferative disorders (eg, essential thrombocythemia) and a number of other associations have been reported. Two cases are described: one associated with essential thrombocythemia and the other the first reported case associated with pernicious anemia.
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A patient with primary cutaneous B cell lymphoma that presented as a solitary nodule on the abdomen was successfully treated with local radiotherapy. A brief review of special studies used to diagnose this tumor as well as clinical characteristics of the tumor is presented.
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Lymphomatoid granulomatosis is a systemic disease marked by a polymorphous cellular infiltrate that is both angiocentric and angiodestructive. The predominant organs of involvement are lungs, skin, central nervous system, and kidneys. I describe two cases of lymphomatoid granulomatosis in association with cutaneous manifestations, stressing to the dermatologist the importance of early recognition and diagnosis of this entity.
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A 33-year-old woman with severe familial hidradenitis suppurativa of the vulva and perineum was treated with a combination of dexamethasone and a new synthetic gonadotropin releasing hormone agonist, leuprolide acetate. The clinical improvement paralleled the adrenal and ovarian suppression, as demonstrated by falling blood levels of testosterone, dehydroepiandrosterone sulfate, androstenedione and estradiol.
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This report describes a 39-year-old woman with pyostomatitis vegetans and ulcerative colitis. Pyostomatitis vegetans is a rare eruption of the oral cavity characterized by tiny yellow pustules coating the surface of the friable eroded mucosa. It is considered a marker for inflammatory bowel disease. In a review of the literature, 19 of 26 cases (73%) reported were associated with gastrointestinal disturbances, predominantly inflammatory bowel disease.
We report a case of an erythema multiforme-like fixed drug eruption in a 30-year-old man who was a known user of various illicit drugs.
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A vesiculobullous eruption is now recognized as a specific but rare cutaneous complication of systemic lupus erythematosus. Four additional cases are reported in whom the five previously proposed criteria were met. Increased activity of systemic lupus erythematosus affecting other organ systems was documented in three of four cases. All four patients demonstrated a positive lupus band, and three of four showed granular deposits of IgA along the basement membrane zone (BMZ). Evidence of glomerulonephritis was obtained in three of four cases, which resulted in death in one. The higher than expected incidence of IgA deposits in skin and renal disease in patients with vesiculobullous eruption of systemic lupus erythematosus is again confirmed. The eruption cleared in all four cases with either dapsone, 50 mg daily, or high doses of corticosteroids and immunosuppressive agents.
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Verrucous carcinoma is a low-grade squamous cell carcinoma. Chronic inflammation is an important factor in its pathogenesis. This is the first case of plantar verrucous carcinoma arising in a lesion of ulcerative lichen planus. This paper also lends further support to the successful use of Mohs micrographic surgical technique as the treatment of choice for verrucous carcinoma.
Our patient presented with a keratotic tumor of the nail bed that simulated a neoplasm. Longitudinal nail bed biopsy showed lichen planus, sparing the patient excisional surgery. We review the differential diagnosis of nail bed tumors, nail biopsy techniques, and the findings of lichen planus of the nail.
Five patients in a large pedigree with autosomal dominant palmoplantar keratoderma and/or an ichthyosiform dermatosis were studied. Biopsies of the keratoderma, a remote hyperkeratotic plaque on an arm and the ichthyosis all revealed the same histopathologic changes including hyperkeratosis with round retained nuclei. All 5 patients had elevated serum beta-glucuronidase activity. The significance of beta-glucuronidase in this and other skin diseases is discussed.