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Biomedical subjects

C Caldwell

Publications and source records attributed to C Caldwell.

67 records · Page 4Linked to original sources
PubMedDate not supplied

Hepatic transplantation survival: correlation with adenine nucleotide level in donor liver.

The hypothesis was tested that human donor livers with higher ATP content and energy charge achieve better results after hepatic transplantation. Biopsies were obtained from 25 donor livers immediately prior to implantation and analyzed for adenine nucleotides using high-performance liquid chromatography. The results were correlated with organ histology, transplant function and outcome. Significantly higher concentrations of ATP (4.22 +/- 2.87 vs. 0.71 +/- 0.69 nmoles per mg protein, p less than 0.01), ADP (8.75 +/- 2.96 vs. 4.49 +/- 1.95 nmoles per mg protein, p less than 0.01) and energy charge (0.43 +/- 0.15 vs. 0.21 +/- 0.04, p less than 0.02) were found in successful (n = 20) relative to failed (n = 5) livers. No significant differences were found in AMP, xanthine or hypoxanthine for the two groups, although the average values were higher in failed livers. Fifteen recipients with liver ATP concentration above 2 nmoles per mg protein and energy charge above 0.3 recovered well. Five other successful patients with lower ATP concentration (0.70 +/- 0.39 nmoles per mg protein) and energy charge (0.20 +/- 0.03) had postoperative courses complicated by infection or prolonged hyperbilirubinemia. In five patients whose livers failed, all had low ATP content and energy charge. Of these, three received a replacement liver and two died shortly after the transplantation. The study demonstrates a direct correlation between high ATP content and good posttransplant outcome.

Adenine Nucleotides↗
PubMedDate not supplied

Working together to improve record keeping.

Implementing changes in a hospital setting requires a structured approach to change management. This article describes the process of a project undertaken to improve record keeping in a children's hospital.

Attitude of Health Personnel↗
PubMedDate not supplied

What healthcare can learn from TQM's past.

Common characteristics and management processes that have caused noteworthy increases in market share, customer satisfaction, and cost reduction can be attributed to TQM initiatives. These common management characteristics and processes include: senior management leadership, strategies centered on customer judgments, strategically aligned department measurements, and an environment that fosters learning.

Consumer Behavior↗
PubMedDate not supplied

Best practices in quality leadership.

In today's competitive healthcare market, leaders face increasing pressure to ensure rapid and lasting improvements at their facilities. Typically, such improvements happen only when senior management provides leadership in two areas--structure and culture. Often this means completely revamping inadequate information systems and developing a better understanding of improvement technology. By employing a number of strategies, such as benchmarking, implementing practice guidelines, and other tactics to make optimal use of existing information, and establishing formal learning plans, healthcare leaders can effect significant and continuing quality improvements within their facilities.

Data Collection↗