ERYTHROCYTE CHOLINESTERASE ACTIVITY IN HEMOLYTIC ANEMIAS.
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Biomedical subjects
Publications and source records attributed to C CHOREMIS.
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In Cooley's anaemia the serum lipid fraction, determined by chemical analysis, was found to be decreased. The lipoprotein distribution by paper electrophoresis showed a characteristic pattern with abnormally low alpha(1) fraction and high concentrations of the beta fractions. There is no relationship between age and serum lipoprotein distribution. A correlation was found between the electrophoretic pattern, liver function tests, and the E/C index. Similar changes but of lesser degree were found in sickle cell anaemia. Liver damage is thought to be the probable cause of the reduced alpha(1) fraction.
Sodium, potassium, water, and the mean corpuscular haemoglobin concentration were determined in the packed erythrocytes of children with severe thalassaemia. The concentration of sodium in the packed red cells was higher than normal in a significant proportion of children with thalassaemia whereas potassium in the packed cells and sodium and potassium in the plasma were normal. On average, the cell water content was a little higher and the mean corpuscular haemoglobin concentration a little lower than normal. The cation concentrations in the packed cells of thalassaemia are compared with those in other anaemias. Similarities are pointed out between the sodium concentrations in the packed cells of thalassaemia and those from the foetus and children suffering from malnutrition.
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