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Biomedical subjects

C C Zhang

Publications and source records attributed to C C Zhang.

45 records · Page 3Linked to original sources
PubMed1986

[Appendectomy and cancer--an epidemiological evaluation].

From Jan. 1958 to June 1983, all in-patients with gastric cancer, breast cancer and carcinoma of colon and rectum (as cancer group), and with cerebral hemorrhage (as control group) in our hospital were epidemiologically investigated in order to evaluate the relation between previous appendectomy and cancer incidence. Patients who had appendectomy more than three years before diagnosed named appendectomized (APP). In cancer group, out of 1,119 patients, 98 (8.76%) were APP, but in the control, only 14 (3.50%) of 400 patients were APP (P less than 0.001). As to cancer location, the ratio of APP were 9.47% (48/507) in patients with gastric cancer (P less than 0.001), 7.07% (21/297) in patients with carcinoma of colon and rectum (P less than 0.05) and 9.21% (29/315) in patients with breast cancer (P less than 0.01). As to sex, the ratio of APP, for the male were 9.82% (46/438) in cancer patients, while 4.47% (8/179) in the control (P less than 0.05), and for the female, were 8.08% (55/681) in cancer patients, while 2.71% (6/221) in the control (P less than 0.01). As to age, the ratio of APP was higher in various age groups of cancer than the control, but only in the 50-59 age group, the difference was significant (P less than 0.05). It shows that the ratio of APP in all cancer groups are significantly higher than those in the controls. The authors support the concept--appendectomy may influence the subsequent cancer risk, and deem it well worth to further investigate.

Adult↗
PubMedDate not supplied

Analysis of genes encoding the cell division protein FtsZ and a glutathione synthetase homologue in the cyanobacterium Anabaena sp. PCC 7120.

Heterocysts, cells specialized in nitrogen fixation in Anabaena sp. PCC 7120, lose the potential for cell division once fully differentiated. This suggests that cell division activity is differentially regulated in heterocysts and vegetative cells. FtsZ has been shown to play a crucial role in bacterial cell division. Two degenerate oligonucleotide primers were designed to detect, by polymerase chain reaction (PCR), an ftsZ homologue from the heterocystous cyanobacterium Anabaena sp. PCC 7120. A PCR-amplified DNA fragment was cloned and used as a probe to isolate the entire ftsZ gene of Anabaena sp. PCC 7120. The deduced amino acid sequence shares strong similarities with other FtsZ proteins, suggesting remarkable conservation of the FtsZ protein during evolution. An ORF downstream of ftsZ, which would be transcribed in the opposite direction compared to ftsZ, could encode a polypeptide with significant sequence similarity to the glutathione synthetase from Escherichia coli. Inactivation experiments in vivo for both ftsZ and the glutathione synthetase gene did not yield any double recombinants either in the presence or in the absence of combined nitrogen, suggesting that both genes are essential for cell growth under these conditions.

Amino Acid Sequence↗