Search PubMed⌕ Search

Biomedical subjects

C C Woo

Publications and source records attributed to C C Woo.

25 records · Page 2Linked to original sources
PubMed1988

Radiological features and diagnosis of acromegaly.

The most constant radiological features of acromegaly include soft tissue hyperplasia, and increased joint spacing, especially in the limbs by articular cartilage overgrowth. Overgrowth is variable in bone. Despite the closure of the epiphysis, articular endochondral overgrowth and subsequent ossification does occur at specific sites as pseudoepiphyseal linear growth. The combined bony apposition-remodeling resorption mechanism, rather than a true osteoporosis, may involve the skull, extremities and spine. Radiological features of the spine have scarcely been reported. The clinical significance of hyperostosis of the spinous process for chronic backache, and vertebral scalloping to compensate for entrapment myelopathy and/or cauda equina syndrome or radiculopathy are overlooked. Further series of radiological assessment of the spine by noninvasive CT scans and plain radiography are recommended. The diagnosis of acromegaly is discussed from a literature review. Deep facial skin-crease testing and dorsal skin-fold assessment of the extremities are recommended as initial screens for evidence of soft tissue hyperplasia.

Acromegaly↗
PubMed1987

Sensitive period for neural and behavioral response development to learned odors.

Olfactory preference training early in life produces both a behavioral preference and an enhanced uptake of 2-deoxy-[14C]glucose (2-DG) in specific areas of the olfactory bulb glomerular layer. We now describe a sensitive period during the first week after birth for the development both of the enhanced neural response and the behavioral preference.

Aging↗
PubMed1987

Localized changes in olfactory bulb morphology associated with early olfactory learning.

Young rats exposed to an odor while receiving reinforcing stimulation come to approach that odor upon subsequent presentation. In addition, such pups have increased 14C-2-deoxyglucose (2DG) uptake within focal areas of the glomerular layer in response to that odor, compared to control animals experiencing the odor for the first time. In this study, the morphology of the glomerular areas underlying these 2DG foci was examined to determine whether early olfactory learning imposed local structural changes that could produce the enhanced 2DG uptake. Alternate sections either were processed with a silver and a Nissl stain to label both cell bodies and their processes or were histochemically treated for the mitochondrial enzymes cytochrome oxidase (CO) or succinic dehydrogenase (SDH) to define the glomerular core of the bulb; 2DG autoradiographs were aligned with adjacent stained sections, and regions underlying the high 2DG uptake foci were examined. In odor-familiar animals, large glomerular clusters that protruded into the external plexiform layer or the olfactory nerve layer were associated with the focal areas of increased 2DG uptake. Morphometric analysis of these regions revealed that the glomerular layer underlying the foci of high 2DG uptake was 30% wider in odor-familiar animals than comparable areas in odor-unfamiliar animals; the cross-sectional areas of individual glomeruli were 21% larger in odor-familiar animals. The foci of enhanced 2DG uptake therefore appear to be associated with groups of enlarged glomeruli. These data demonstrate that early olfactory learning influences the morphology of the olfactory bulb.

Animals↗
PubMed1987

Hyperostosis of lumbar spinous process: a radiological feature in a young acromegalic.

Hyperostosis of the spinous process may be associated with diffuse idiopathic skeletal hyperostosis, Baastrup's disease or acromegaly. Radiological differential diagnosis between them are discussed. No case of hyperostosis of the spinous process has been described clinically or radiologically in young acromegalics. This case represents another manifestation of spinal involvement of acromegaly. Coincidentally, the enthesopathy could also be seen clearly in the middle and proximal phalanges in this young patient. Physicians treating spinal diseases should be aware of chronic backache due to the microtrauma of "kissing" hyperostosis of spinous processes, especially in posterior weight-bearing patients. Hyperostosis of the spinous process, platyspondyly or scalloping of posterior vertebral body, when present alone, is not a diagnostic criteria for acromegaly. But their coexistence in a vertebra is pathognonomic and may serve as an additional diagnostic criteria for acromegaly, especially in young adults.

Acromegaly↗
PubMed1987

Traumatic radial head subluxation in young children: a case report and literature review.

Traumatic radial head subluxation in young children is reviewed. This minor condition commonly results from a sudden longitudinal traumatic pull on pronated and extended forearm and appears to be infrequently recognized or diagnosed. Differential diagnosis of traumatic radial head subluxation from traumatic radial head dislocation, congenital radial head dislocation, brachial plexus palsy and "invisible" elbow fractures are discussed. It is postulated here that there are two types of traumatic rotary radial head subluxation in pronation, the simple type and the lateral type. Careful analysis of anteroposterior view of elbow reveals the change of the shape and position of the radial tuberosity indicating the simple type, or concommitant with lateral displacement of the radial head on the ulna indicating the lateral type. The lateral type and its reposition are demonstrated when premanipulative roentgenograms are compared with postmanipulative roentgenograms in one of the eight illustrative cases. Details of the supination manipulative reduction are described and demonstrated.

Child, Preschool↗
PubMed1986

Manipulative treatment of backache in a young acromegalic: a case report.

Early onset of disabling backache in acromegaly is infrequent. A case is presented of a young acromegalic with acute sacroiliac strain caused by improper occupational lifting, precipitated by the instability of joints due to hypersomatotropism and concomitant with lumbosacral facet tropism. The newly observed radiological feature of the acromegalic, hyperostosis of the spinous processes is believed to contribute to the aching in the low back. The patient resumed working after ten adjustments to the sacroiliac joint, supplemented with cryotherapy, sacral brace and postural education. It is postulated that backache in acromegalics is primarily related to acute accidental, or to chronic repeated, occupational or recreational microtraumas to the low back or to the hyperostosis of the lumbar spinous processes.

Acromegaly↗