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Biomedical subjects

C C Wilson

Publications and source records attributed to C C Wilson.

At least 55 records · Page 3Linked to original sources
PubMed1988

Analysis of conformational parameters in nucleic acid fragments. II. Co-crystal complexes of nucleic acid bases.

Studies have been made of conformational parameters in co-crystal complexes and compounds of nucleic acid bases in which there is the possibility of formation of hetero-base-pairs. Using published data extracted from the Cambridge structural database, a total of 37 base-pairs were found, of which 25 were hetero-pairs and 12 homo-pairs. These base-pairs were subject to analysis to reveal hydrogen bond parameters, propeller twist, buckle and C1'-C1' separation (or a similar parameter if C1' atoms were not present). Hetero-pairs were found to show larger twists than homo-pairs, the magnitude of twist being unrelated to hydrogen bond parameters or buckle value. The propeller twisting is less pronounced in these nucleic acid bases than in nucleosides, but still has a significant magnitude. Propeller twisting in hetero-pairs is found to be larger than in homo-pairs. Hetero-pairs appear to be formed preferentially in competitive situations.

Crystallization↗
PubMed1988

State screening for metabolic disorders in newborns.

Most states have mandatory screening programs for congenital and inherited disorders of metabolism. Physicians may be unaware of their state's requirements, and compiled lists of testing requirements are generally unavailable or incomplete. All states test for congenital hypothyroidism and phenylketonuria. Some states require that newborns be tested for up to six other specific congenital and inherited disorders of metabolism. Some states base their decision to test on demographic data, but there is no uniformity in the tests.

Adrenal Hyperplasia, Congenital↗
PubMed1987

Analysis of conformational parameters in nucleic acid fragments. I. Single crystals of nucleosides and nucleotides.

A study has been undertaken of conformational parameters in single crystal structures of nucleosides and nucleotides using the techniques of helical conformational analysis. A "quasi-helix" was generated from the geometry of base-paired structures, using published data extracted from the Cambridge structural database. A total of 54 base-pairs were found in these structures, for each of which were calculated hydrogen bond parameters, propeller twist, buckle and C1'-C1' separations. These were analysed according to various classifications. Propeller twists are found to show a wide range of values and the magnitude of twist appears to be unrelated to hydrogen bond parameters or C1'-C1' separation. The values of the buckle parameter vary over a smaller range of values and are unrelated to propeller twist magnitude. There is found to be a greater tendency to form homo-base-pairs among compounds containing adenine bases.

Base Composition↗
PubMed1987

The interaction of antibody/DNA immune complexes with complement. Influence of antibody class and DNA conformation.

In 28 serum and plasma samples from patients with systemic lupus erythematosus, we examined the importance of antibody class with respect to complement-mediated binding to human red blood cells (RBC) of antibody/DNA immune complexes (IC) prepared with anti-DNA antibodies. We used both 3H-double-stranded DNA and 3H-single-stranded DNA (ssDNA). Generally, double-stranded DNA IC showed considerably higher binding than did ssDNA IC in the RBC binding assay. Further analysis indicated that although ssDNA IC fix complement, it is necessary that these IC contain IgM anti-DNA antibodies in order for them to bind to RBC. The results suggest that the mechanisms of clearance and pathogenic potential of these IC may depend upon both the DNA conformation and antibody class. In particular, complement-fixing IC which contain IgG anti-DNA antibodies and ssDNA may not be cleared via the erythrocyte clearance mechanism, and therefore, could be more likely to deposit in certain tissues and initiate inflammatory reactions.

Antibodies, Antinuclear↗
PubMed1987

Physiological responses of college students to a pet.

The effect of a pet on cardiovascular responses of college students was examined under three test conditions (i.e., reading aloud, reading quietly, and interacting with an unknown dog). A repeated-measures analysis with three covariates was used to examine the effect of the treatment on each of six dependent variables (systolic blood pressure, diastolic blood pressure, mean arterial pressure, heart rate, and State and Trait Anxiety). Reading aloud differed from baseline measures under all treatment conditions (p less than .001) Reading quietly and interacting with a pet were slightly below baseline for all dependent variables with a slightly greater effect by reading quietly than interacting with a pet. Examination of interactions between variables revealed no significant differences. Effects on State anxiety level mirrored cardiovascular responses (p less than .001). Trait anxiety levels remained relatively constant throughout the treatments. Results indicated that interacting with a pet does affect physiological and psychological responses by lowering response levels. A parallel effect was also demonstrated by reading quietly. Given the effect of pet interaction upon selected indicators of health in well college students, these data suggest the relevance of examining this treatment with an "at-risk" group.

Adult↗
PubMed1987

Comparison of self and health professionals' ratings of the health of community-based elderly.

Perceptions of 269 community-based elderly persons and eighty health-care professionals were compared for opinions related to the health-care needs of the elderly, and major barriers faced by the elderly to the utilization of health services. The data indicate a high degree of incongruence between the perceptions of the elderly and those of the professionals. Health professionals were not good predictors of the health status of the elderly, and they did not accurately predict the barriers faced by the elderly seeking health care. Congruence of responses was found only related to the cost of health services. Reasons for these differences were explored, and recommendations for future program planning were made.

Activities of Daily Living↗
PubMed1983

Companion animals and the elderly: a state-of-the-art summary.

The human/animal relationship exhibited by the elderly and their pets has limitations as well as potentials. The functions of a pet as a companion and social facilitator in pet-facilitated psychotherapy include serving as a cotherapist for facilitation of rapport, providing companionship, substituting for close interpersonal relationships (ie, significant others), enhancing the health status of a variety of target groups, increasing opportunity for sensory stimulation, and providing emotional support and a sense of well-being. Available information was limited because few studies have been replicated, data were not validated, and previous studies were restricted mainly to institutionalized or therapeutic environments. Implications for future research include use of animals for companionship and to promote the physical, social, and emotional health of the elderly.

Aged↗
PubMed1983

Chlorpromazine effects upon rabbit lens water and electrolyte balance.

Chlorpromazine (CPZ) concentrations of 5 x 10(-5)M or greater were found to disrupt lens electrolyte and water balance significantly. Lens sodium and calcium levels increased while potassium decreased. These changes were accompanied by water accumulation. Such effects of CPZ were not dependent upon exposure to ultraviolet light. Electrical measurements revealed that CPZ induced depolarization of the lens potential but little change of overall lens conductance. 86Rb efflux from the lens was unaltered by a 1 hr exposure to CPZ. The active sodium pump in the lens was inhibited by CPZ, as evidenced by a reduction in Na- K-ATPase activity.

Animals↗
PubMed1982

Human triploidy: relationship between parental origin of the additional haploid complement and development of partial hydatidiform mole.

One hundred and six triploids were ascertained during a study of 1500 consecutive spontaneous abortions. The mechanism of origin of the additional haploid complement was investigated by comparing parental and foetal cytogenetic heteromorphisms and a histopathological examination of each triploid was done in a subsequent blind study. The mechanism of origin of the additional haploid complement was found to be highly correlated with the development of partial hydatidiform mole and with gestational age. All 51 paternally derived triploids in which a pathologic diagnosis could be made were partial moles, whereas only 3 of 15 maternally derived triploids on which a diagnosis could be made were molar. The mean gestational age of the paternally derived triploids was 122 days while that of the maternally derived triploids was only 74 days. It was suggested that the development of partial mole was primarily associated with the presence of two paternal haploid chromosome complements, the association with relatively long gestational ages being a secondary one consequent upon retention of the molar placentae for many weeks after foetal demise.

Abortion, Spontaneous↗
PubMed1982

Complete and partial hydatidiform mole in Hawaii: cytogenetics, morphology and epidemiology.

The results of a 5 year prospective cytogenetic and epidemiologic investigation of complete and partial hydatidiform mole are described. A total of 40 complete and 88 partial moles were identified by pathologic criteria in a population of 1602 spontaneous abortions. Cytogenetic observations confirmed the close correlation between chromosome constitution and histopathologic type, virtually all the complete moles were paternal parthenogenones and virtually all the partial moles were triploid. The distributions of maternal age, race, place of birth and socioeconomic status were the same in women with partial moles and in the control population of spontaneous abortions. However, the incidence of complete moles was significantly increased in women aged less than 20 years and also in Filipino women, these two effects being independent of one another.

Abortion, Spontaneous↗
PubMed1981

Hyperactive and aggressive behaviors in childhood: intertwined dimensions.

The relationship between aggression and hyperactivity is unclear in childhood hyperkinesis. To examine the relationship between the two dimensions, a sample of 109 first-, second-, and third-grade children who were rated as hyperactive were evaluated daily by their teachers for 12 consecutive school days on the Daily Behavior Checklist. Daily recordings were made on a total of 22 specific behaviors, 11 physically or verbally aggressive acts, and 11 acts of a restless or hyperactive nature. The Conners hyperactivity score correlated .47 with daily aggression and .49 with daily hyperactivity. A subgroup of hyperactive children who exhibited both hyperactive and aggressive behaviors at rates greater than 98% of their classmates was selected. These children were rated significantly higher on the Conners scale than on alternate subgroup of hyperactive children who showed high rates of hyperactive but not aggressive behaviors. In view of heavy reliance on teacher ratings with the Conners scale in studies of hyperactivity, careful consideration of the potential confounding of hyperactivity and aggression is recommended. Implications for classification, longitudinal investigation, and evaluation of treatment of hyperactive children were discussed.

Age Factors↗
PubMed1980

Society for Public Health Education: survey of membership.

The Society for Public Health Education, Inc. (SOPHE), through the Research and Evaluation Committee (REC) of the Tennessee chapter has surveyed its membership to determine characteristics of members, members' opinions of the organization and the benefits derived, usefulness of SOPHE publications, and the most important health education issues and goals. Survey results provide an employment profile of the membership, and indicate the membership benefits which are most valued; they also suggest that the organization's goals and its activities be expanded in scope to include, in addition to other areas, greater attention to health education practice, to planning legislation, to funding, and to cooperation with the American Public Health Association in the general promotion of health education. REC presents recommendations based on these findings.

Employment↗
PubMed1979

Biofeedback treatment of atopic dermatitis: controlled case studies of eight cases.

To investigate the feasibility of a behaviorally oriented intervention program with atopic dermatitis, 12 patients were exposed to a fixed sequence of treatment phases including a no-treatment baseline phase, a phase incorporating nonspecific treatment factors, and a phase involving frontal electromyographic (EMG) feedback and relaxation instructions. Photographic analyses of involved skin areas revealed significant remission of dermatological problems across the entire program, although significant changes could not be attributable to any specific phase. Ratings of itching level decreased within but not across treatment sessions, and variable correlations across subjects were found between frontal EMG and itching level. MMPI results from the dermatitis subjects were within normal limits. Overall, the results provided mixed support for the hypothesis that atopic dermatitis may be amenable to intervention through behaviorally oriented treatment procedures.

Adolescent↗
PubMed1979

Frontal electromyographic feedback. Stress attenuation and generalization.

This study evaluated the effects of one session of frontal electromyographic (EMG) feedback on (1) frontal EMG, (2) frontal EMG response to stress, (3) cardiovascular variables, and (4) cardiovascular responses to stress. Eighteen male and female undergraduate volunteers received either frontal EMG feedback or a relaxation instructions control procedure and were then exposed to a fear stimulus (visualization of a feared situation) and a post-stress adaptation period while several cardiovascular measures were monitored. In comparison to the control group, frontal EMG feedback significantly reduced resting levels of frontal EMG and frontal EMG response to stress but had no significant effect on cardiovascular measures. The results of this study suggest that one session of frontal EMG feedback may attenuate response to stress but, within the paradigm utilized, may be confined to the specific muscle groups monitored. Additional areas of needed research were noted including individual differences in generalization, the effects of EMG feedback from multiple sites sequentially and concomitantly, and the generalized effects from symptom-specific sites.

Adolescent↗