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Biomedical subjects

C C Shih

Publications and source records attributed to C C Shih.

88 records · Page 5Linked to original sources
PubMed1984

Migration patterns and functional activity of cloned cytotoxic T lymphocytes in syngeneic and allogeneic mice.

The quantitative distribution of cytolytic T lymphocytes (CTL) generated in mixed leukocyte culture (MLC) and an interleukin-2 (IL-2)-dependent, CTL clone (WRL-A3) was investigated in various tissues of irradiated syngeneic and allogeneic mice. In addition, the ability of the WRL-A3 CTL clone to remain viable and retain antigen specificity following in vivo passage was evaluated. Injection i.v. of 51Cr-labeled cultured CTL resulted in: (1) extensive deposition of cells in the lungs with significantly more lymphocytes being recovered in allogeneic as compared with syngeneic lung tissue; (2) minimal accumulation in spleen with more in syngeneic than in allogeneic tissue; and (3) no localization in blood, femurs, thymus, or lymph nodes. The migration rate of cultured CTL exiting the lung during the first 4 hr was markedly faster in syngeneic than in allogeneic recipients and was directly associated with the distribution of these cells in other tissues at 24 hr. The WRL-A3 CTL clone recovered from irradiated syngeneic and allogeneic lung tissue at 1, 3, 6, 8, and 13 days after i.v. injection remained viable, even though no exogenous IL-2 was administered to the recipient mice. The recovered cells proliferated when recultured with IL-2, and retained their antigen specificity for Qed-1b target cells after in vivo passage. These findings indicate that restricted and undesirable tissue distribution, rather than impaired viability or loss of antigenic specificity, is the major obstacle to successful use of cultured CTL for adoptive immunotherapy of disseminated cancer.

Animals↗
PubMed1975

Epidemiologic studies of eosinophilic meningitis in southern Taiwan.

A study of the epidemiologic characteristics of 125 cases of eosinophilic meningitis or meningoencephalitis, probably caused by Angiostrongylus cantonensis, which occurred in southern Taiwan in 1968 and 1969 revealed a close association of the disease with the rainy season. In contrast to findings in other geographic areas, most such cases in this study occurred among children. A higher attack rate was observed among aborigines than among descendants of mainland Chinese. Most patients had eaten the giant African snail, Achatina fulica, prior to their illness and this mollusc was commonly found infected with third-stage larvae of A. cantonensis. However, in almost all instances the snail was eaten after it had been thoroughly cooked and examination of cooked snail meat revealed only dead larvae. It is suspected that patients became infected by inadvertently ingesting A. cantonensis larvae liberated when the snails were prepared for consumption.

Adolescent↗
PubMedDate not supplied

Synthesis of the spin-labeled derivative of an ether-linked phospholipid possessing high antineoplastic activity.

We report here the complete synthesis of the spin-labeled derivative of an antitumor ether phospholipid, 1-O-octadecyl-2-O-(4'-doxylpentyl)-rac-glycerol-3-phosphocholine. This also represents the first time that the synthesis of a nitroxide spin-labeled diether phospholipid is described. In vitro experiments showed that at micromolar concentrations, this new analog is readily incorporated into the plasma membranes of human HL60 and mouse E8/AK.D1 leukemic cells, and subsequently kills the cells. The availability of this new probe should permit the electron spin resonance spectroscopic approach to investigate ways by which anti-tumor ether phospholipids selectively destroy the tumor cells.

Animals↗
PubMedDate not supplied

High energy electron radiotherapy in a magnetic field.

We propose the use of high energy electrons in a strong local magnetic field as the ionizing beam in radiation therapy. A high kinetic energy insures that the electrons will penetrate to deep-seated tumor masses. A high magnetic field of several tesla in the region encompassing the tumor will confine the high energy electrons to the tumor volume before the scattering of the beam becomes excessive, thus producing an enhanced electron "Bragg peak" and highly localized strong radiation dose. The conclusions are based on a detailed Monte Carlo model which includes Landau straggling, multiple scattering, and the space dependence of the magnetic field.

Electrons↗
PubMedDate not supplied

CD3 complex.

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Amino Acid Sequence↗
PubMedDate not supplied

CD54 (ICAM-1).

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Amino Acid Sequence↗
PubMedDate not supplied

CD102 (ICAM-2).

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Amino Acid Sequence↗
PubMedDate not supplied

Pulmonary hypoplasia associated with oligohydramnios: report of five cases.

From January 1986 to December 1988, 5 cases of oligohydramnios with pulmonary hypoplasia were experienced. Clinically, all of the newborn infants had unique faces and evidence of respiratory distress with tachypnea, cyanosis, intercostal retractions, nasal flaring and grunting respiration presented within minutes after birth. Usually, they had no response to respiratory therapy. Most of them showed small lung volume by chest roentgenogram and were prone to develop pneumothorax. All 5 cases did not survive more than a few hours. Autopsy findings disclosed pulmonary hypoplasia. Four of them had urinary tract malformation, and the other one had the history of prolonged leakage of amniotic fluid.

Female↗
PubMedDate not supplied

Acute diffuse phlegmonous esophagogastritis: report of a survived case.

A 42-year-old man was admitted because of a persistent pain on swallowing together with epigastralgia, chest pain, fever, and shortness of breath for 5 days. An unbearable shortness of breath with a retrosternal pain was noted each time he tried to lie down. The patient also developed bilateral pleural effusion and pericardial effusion. Ten days after admission, he underwent an emergency laparotomy after an acute episode of severe epigastralgia with hematemesis and rebound tenderness limited to the epigastrium. Operative findings showed diffuse phlegmonous esophagogastritis. A near-total esophagectomy and a total gastrectomy were done. He lost 15 kilograms of body weight and was discharged 3 months later. The patient underwent reconstructive surgery 2 months after discharge, recovered well and regained his weight within one year.

Adult↗