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Biomedical subjects

C C Seltzer

Publications and source records attributed to C C Seltzer.

At least 19 recordsLinked to original sources
PubMed1991

The negative association in women between cigarette smoking and uncomplicated angina pectoris in the Framingham Heart Study data.

As a result of a more complete analysis of available Framingham Heart Study data on the association of cigarette smoking to incidence of uncomplicated angina pectoris than has previously been published in Framingham papers, it was determined that there is a consistently negative risk factor association for women at every follow-up period from 12 to 30 years, with Framingham women cigarette smokers experiencing 30-40% lower rates of uncomplicated angina pectoris than non-smokers, the rates also declining with increasing amounts of cigarettes smoked. Our analysis confirms the absence of a predictive risk factor association in the case of men previously indicated by Framingham investigators. The published declarations by Framingham investigators of an absence of association between cigarette smoking and angina pectoris in Framingham women, is a failure to publicly recognize the distinctive negative association present in the Framingham female data. The Framingham data on the relationship of smoking to angina incidence is clearly at variance with the Surgeon General's sketchy finding of an inconsistent positive association for men and an uncertain relationship for women. It is suggested that special attention should be directed to these results of the Framingham data because of the preeminence of Framingham material world wide, because angina pectoris is the most common manifestation of coronary heart disease, because it will improve the "conventional wisdom" on this subject, and because the negative relationship found for Framingham women does not lend support to the belief held by some that smoking enhances the degree of coronary atherosclerosis.

Adult↗
PubMed1989

Framingham study data and "established wisdom" about cigarette smoking and coronary heart disease.

With the Framingham Heart Study widely recognized as the most comprehensive, sustained investigation of the precursors of coronary heart disease (CHD), an examination was made of its manifold published data on the relationship of cigarette smoking to CHD and the results were compared with the "conventional wisdom" about cigarette smoking and CHD as projected by the Surgeon General. The analysis of data in the Framingham Heart Study shows that its results are inconsistent with the Surgeon General's views about cigarette smoking and coronary heart disease. The inconsistencies refer to (1) the magnitude of the association between cigarette smoking and CHD; (2) the relative incidence of CHD in "heavy" smokers and nonsmokers; (3) the independent effect of cigarette smoking on CHD; (4) the increasing risk of developing CHD with duration of cigarette smoking; (5) the effect of smoking cessation; and (6) the association between cigarette smoking and CHD in women.

Adult↗
PubMed1987

Adolescent smoking and early respiratory disease: a longitudinal study.

The data from a longitudinal study involving 1,445 white boys and girls from the San Francisco Bay area revealed a significant association between the adoption of cigarette smoking in adolescents with a history of either asthma or bronchitis in childhood and in early and middle teenage years. The association, present in both sexes, is stronger for bronchitis than for asthma, with the strength and direction of the association unaffected by such potentially confounding variables as parental smoking, socioeconomic status, psychosocial traits, etc. Age of onset of asthma (primarily in early childhood) preceded the commencement of smoking in 90% of subjects, indicating that cigarette smoking is not causally related to the development of childhood and adolescent asthma. With respect to bronchitis, however, as a result of the data on age of onset and the temporal relationship with the adoption of smoking, the possibility that cigarette smoking among adolescents may contribute to bronchitis cannot be dismissed.

Adolescent↗
PubMed1985

Psychosocial characteristics of adolescent smokers before they started smoking: evidence of self-selection. A prospective study.

Evidence of noncomparability of self-formed smoker and nonsmoker groups of adolescents from the Child Health and Development Studies of the University of California, Berkeley, was found in a study of antecedent psychosocial characteristics (observed at age 10) before the adoption of the smoking habit. With possible confounding factors controlled, eventual smokers showed significantly greater prevalence than nonsmokers of Type A personality traits, extraversion, psychoticism, anger, and restless sleep. Eventual smokers were lower in socioeconomic status than nonsmokers, and also exhibited significantly lower mean scores for the Raven Progressive Matrices and Peabody Picture Vocabulary tests. For each trait, the trends of the data were consistent in boys and girls. Since many of these traits are shown to "track" into adult life, where they are then related to coronary heart disease, the role of self-selection requires further consideration in causal inferences about smoking and coronary heart disease.

Adolescent↗
PubMed1978

Cigarette smoking habits and urine characteristics: urinalysis abnormalities are more common is smokers, but the reasons are unclear.

Voided urines of 53,000 white and 9,3000 black cigarette smokers and nonsmokers were studied. Proteinuria was found to be commoner in smokers of both races and sexes. Heavy smokers showed proteinuria more frequently than light smokers. Of eight possible explanatory variables, one, alcohol consumption history, showed some interrelationship in that the smoking status-proteinuria association disappeared among heavy drinkers. Stopping smoking was not associated with a relative decline in proteinuria prevalence. Proteinuria associated with smoking did not appear to be indicative of more serious renal disease. There was a smoker-nonsmoker difference in urine glucose response to oral glucose challenge, apparently explained by higher average 1-hour serum glucose values for smokers, of unknown mechanism but partially explained by differences in alcohol usage. Hematuria, bacteriuria, and high urine acidity tended to be more prevalent in smokers, though these relationships were not consistently significant.

Adult↗
PubMed1977

Army rank and subsequent mortality by cause: 23-year follow-up.

Mortality among veterans has been studied in relation to military rank at separation in a series of 85,491 men discharged from the US Army in 1946 and traced through 1969. It was found that although the mortality of privates was very close to expectation based on population rates, non-commissioned officers had a 23% advantage and commissioned officers about a 40% advantage. The relative advantage of the veterans who had higher rank held not only for deaths from all causes but also for most of the specific causes examined and there was only a small tendency for the differences to diminish with the passage of time during the 23-year period of follow-up.

Adolescent↗