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Biomedical subjects

C C Li

Publications and source records attributed to C C Li.

At least 73 records · Page 4Linked to original sources
PubMed1990

[A pathological study of primary malignant lymphomas of the thyroid].

Thirty cases of a primary malignant lymphoma (ML) have been studied clinicopathologically and immunohistochemically. The average age of the patients was 59.1 years, and the ratio of males to females was 1:1.7. According to the Kiel classification of MLs, 53.3% had a low grade malignancy and 46.7% were a high grade malignancy. Therefore, the number with a low or a high grade malignancy was almost equal. Most of the low grade malignancies were ML, centroblastic centrocytic, and most of the high grade malignancies were ML, lymphoblastic. From histopathological and immunohistochemical studies, most cases were considered to be of B-cell origin and two thirds of the cases were regarded as being of a follicular center cell origin. Prognosis was better than that of other MLs. Finally, MLs of the thyroid were found combined more frequently with chronic thyroiditis of the Hashimoto type than malignant epithelial neoplasms.

Adult↗
PubMed1990

[Changes of creatine phosphokinase and malondialdehyde in the serum and clinical use of large doses of vitamin C following open heart surgery].

The protective effect of a large dose Vit. C on ischemic myocardium was studied on 10 patients who underwent open heart operation and received 250 mg/kg Vit. C before the start of ECC (Group II). Another 10 similar patients receiving no Vit. C served as a control (Group I). Blood samples were taken from the brachial artery at different time intervals for determination of CPK-MB and MDA in both groups. Considerable increases of serum CPK-MB and MDA in both group I and II were noted. The differences of CPK-MB and MDA concentration between Group I and II were highly significant from 2 to 12 hours postoperatively. The effect of Vit. C in the reduction of the release of CPK-MB and MDA after open heart operation was attributed to its action as an oxygen free radical scavenger, thus decreasing the peroxidation of the lipids present in the cell membrane.

Adolescent↗
PubMed1989

Role of beta-receptor in the radix Angelicae sinensis attenuated hypoxic pulmonary hypertension in rats.

Acute pulmonary hypertension was caused by inhalation of 5% O2 in rats. Pulmonary vascular resistance (PVR) increased, but heart rate (HR), cardiac output (CO) and carotid arterial pressure (CAP) were not obviously changed. After an intravenous administration of Radix Angelicae sinensis, the acute pulmonary hypertension induced by inhalation of 5% O2 could be attenuated, but this effect disappeared if propranolol was given before Radix Angelicae sinensis. In chronic experiments, the same results were obtained, but the protective effect of Radix Angelicae sinensis on heart function was not influenced by propranolol. It is suggested that Radix Angelicae sinensis might play a role by stimulating the beta 2-receptor in the prevention of acute and chronic hypoxic pulmonary hypertension. However, prevention of hypertrophy of the right ventricle and enhancement of heart function in chronic hypoxic rats might not be attributed to the beta 1-receptor in the heart.

Adrenergic beta-Agonists↗
PubMed1989

Effect of chuanxiongqin (tetrame-thylpyrazine) on microcirculatory perfusion in hamsters and capillary permeability in rats.

The authors continuously observed the effect of Chuanxiongqin on the microcirculation of hamster cheek pouch by use of the Dual-Window Television Automatic Estimating System. It was seen that the caliber of arterioles, the microcirculatory velocity, and blood flow all decreased after local application of noradrenaline and all increased and returned to normal 1 to 30 min after local administration of Chuanxiongqin. Microcirculatory perfusion, however, could not be improved by normal saline or Iluangqi. The effect of Chuanxiongqin on the pulmonary capillary permeability was also investigated in rats. Pulmonary edema was induced in rats by adrenaline administration. Evans blue was injected intravenously and the amount of Evans blue in broncho-alveolar lavage fluid was estimated. It was found that Evans blue was increased in broncho-alveolar fluid of rats with pulmonary edema, and this increase could be lessened by Chuanxiongqin.

Animals↗
PubMed1989

[Effect of triptolide on cytokinetics of HeLa cells].

The cytostatic effects of triptolide on HeLa cells in different proliferation stages and cell cycle phases were studied by colony-forming units assay. An exposure of exponential-phase cells to triptolide 0.02-4.00 micrograms/ml for 0.5 h resulted in a biphasic-exponential dose-survival curve (n = 1, D0 = 0.3 micrograms/ml in the most sensitive population; D0 = 2.8 micrograms/ml in the more resistant population). The plateau-phase cells in the same conditions seemed to have lower sensitivity to the drug. The synchronized cells caused by excess TdR double block and the selective detachment of mitotic cells from monolayer were exposed to triptolide 0.06 micrograms/ml for 0.5 h. The sensitivity of cell cycle phases to the drug ranked as follows: S greater than G2, M greater than G1. The result showed that triptolide is one of the cell cycle phase non-specific agents, but more sensitive to S phase cells.

Antineoplastic Agents, Phytogenic↗
PubMed1988

Pseudo-random mating populations. In celebration of the 80th anniversary of the Hardy-Weinberg law.

That random mating leads to Hardy-Weinberg distribution of genotypes is well known. This report is to show that, if the deviations from random mating are of a certain pattern, the offspring generation will also be in Hardy-Weinberg proportions. This brings out the fact that random mating is a sufficient condition, not a necessary one, for the attainment of the Hardy-Weinberg proportions. Such nonrandom-mating populations are tentatively said to be pseudo-random mating. Pseudo-random-mating populations exist for both autosomal and sex-linked systems with two or multiple alleles. This report covers the basic case of a two-allele autosomal locus in detail, but the possible extension to two loci and cytonuclear systems have also been mentioned in discussion.

Alleles↗
PubMed1988

Identification of the human papillomavirus E2 protein in genital tract tissues.

A 27-kilodalton protein representing approximately 60% of the E2 open reading frame of human papillomavirus type 6 (HPV-6) was synthesized in a bacterial expression system. Affinity-purified polyclonal antibody to this protein detected the probable E2 gene product as a 50-kilodalton protein in most condylomas by Western blot (immunoblot) analysis. The E2-positive condylomas were associated with HPV-6, HPV-11, HPV-16, or unidentified HPVs.

Condylomata Acuminata↗
PubMed1988

A genetical model for vitiligo.

A genetical model is found to provide a good fit to family data on vitiligo. The model postulates that recessive alleles at a set of four unlinked diallelic loci are involved in the causation of the disorder. Under this multiple recessive homozygosis model, for normal X affected families ascertained through the affected parent, the expected segregation probability is .063; the estimated value is 0.53, which is not significantly different from the expected value. For normal X normal families ascertained through an affected offspring, the expected segregation probability is .037; the estimated value is .04.

Age Factors↗
PubMed1988

An expository review of two methods of calculating the paternity probability.

There are two methods for calculating the posttests probability of paternity, viz., the nonexclusion probability method (E method) and the paternity index method (lambda method). This report reviews these two methods and explains the reasons behind them, in the hope that it might alleviate the current controversy between the advocates of these two methods. The emphasis throughout the paper is on exposition, using simple examples to illustrate certain principles or properties. A discussion follows the presentation of the two methods. The calculation of the paternity index is based on the genotype (or phenotype) of the accused man; and the value of the paternity index remains the same whether the accusation itself is true or false.

Biometry↗
PubMed1987

Estimation of segregation and ascertainment probabilities by discarding the single probands.

The first portion of this communication reiterates the method of discarding single probands for studying the segregation ratio under incomplete ascertainment. The organization of the algebra leads to the second portion, in which the "self-contained" subsets are constructed with respect to both the segregation ratio and the ascertainment ratio. These subsets make a more detailed study of segregation and ascertainment possible.

Genetic Diseases, Inborn↗
PubMed1987

Tests of linkage and heterogeneity in Mendelian diseases using identity by descent scores.

When linkage between a recessive Mendelian disease and specific candidate genes is investigated, identity by descent scores in affected sib pairs may be used for tests of linkage and heterogeneity. Statistical tests for performing this analysis are presented. The efficiency and statistical power of the method are also investigated using computer simulations.

Biometry↗
PubMed1987

An improved technique of radical neck dissection with an analysis of long-term results of 1,000 operated cases of head and neck cancer.

An improved technique of radical neck dissection is presented with a report of all 1,000 operated cases of the head and neck region from 1964 to 1980 at the Affiliated Tumor Hospital of Zhongshan Medical College, in Guangzhou, China. The practice has proved that our operative procedures are time-saving, with less blood loss during operation, fewer operative mortalities, fewer complications, better end results, better cosmetic effects, and that the techniques are easier to master.

Adolescent↗
PubMed1987

Identification of the human papillomavirus type 6b L1 open reading frame protein in condylomas and corresponding antibodies in human sera.

Genital warts (condylomata acuminata) are among the most frequent sexually transmitted infections. Human papillomavirus type 6 (HPV-6), which is etiologically related to a majority of these lesions, has not been propagated in tissue culture. We generated two forms of HPV-6 viral antigens: a chemically synthesized oligopeptide (referred to as the C-terminal synthetic peptide) corresponding to residues 482 to 495 of the 500-amino-acid-long L1 open reading frame (ORF), and a bacterially expressed 54-kilodalton (kDa) fusion protein containing the N-terminal 13 amino acids encoded by the lambda bacteriophage cII gene followed by one vector-insert junctional residue and 462 amino acids of the L1 ORF sequence (residues 39 to 500). The cII-L1 fusion protein was specifically recognized by an antipeptide serum directed against the N-terminal 13 amino acids derived from the cII gene, an antiserum raised against the C-terminal synthetic peptide, and a genus-specific serum prepared by immunization with disrupted viral capsids. The 54-kDa fusion protein was purified, and the sequence of its first 36 amino acids was determined and found to be as predicted by the DNA sequence. Both the genus-specific anticapsid serum and the antiserum raised against the fusion protein identified authentic L1 ORF proteins in HPV-1-induced (58 kDa) and HPV-6/11-induced (56 kDa) papillomas. The synthetic peptide antiserum recognized the 56- to 58-kDa protein in HPV-6-induced warts, but not in HPV-1- or HPV-11-infected specimens. Using the fusion protein as antigen in immunoassays, we were able to detect the corresponding antibodies in human sera.

Antibodies, Viral↗
PubMed1987

A genetical model for emergenesis: in memory of Laurence H. Snyder, 1901-86.

When a phenotype is determined by a specific gene combination of several loci, it is called an emergenic trait. Such a trait, although genetically controlled, does not usually run in families, since the specific gene combination can hardly be preserved in the process of reproduction. The present paper suggests a concrete genetical model to account for the phenomenon that there is little resemblance between siblings and parent-child pairs with respect to this trait. The genetical model is multiple homozygosis for all loci involved in the gene configuration. The properties of such a trait in a random mating population for all families, as well as for the segregating families only, are investigated. Some of the difficulties in estimating the genetical parameters on the basis of empirical data are also discussed.

Genetics, Behavioral↗