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Biomedical subjects

C C Kuni

Publications and source records attributed to C C Kuni.

68 records · Page 4Linked to original sources
PubMed1981

Clinical comparison of diisopropyl-IDA Tc 99m and diethyl-IDA Tc 99m for evaluation of the hepatobiliary system.

Thirty-one patients with a wide range of hepatobiliary function and clinical diagnoses were studied with both diisopropyl-IDA Tc 99m and diethyl-IDA Tc 99m. Images were similar except for an increased liver-to-kidney ratio with diisopropyl-IDA Tc 99m (p less than 0.01) and a tendency toward an increased liver-to-background ratio at five minutes with diisopropyl-IDA Tc 99m (p greater than 0.05). Quantification of the relative hepatocyte extraction efficiency indicated a 16% higher extraction efficiency for diisopropyl-IDA Tc 99m (p greater than 0.05). Cumulative three-hour urine collections following injection demonstrated no significant difference in renal excretion in patients with normal total serum bilirubin levels. Both radiopharmaceuticals demonstrated increasing renal excretion with increasing total serum bilirubin levels; however, renal excretion of diisopropyl-IDA Tc 99m increased more slowly than excretion of diethyl-IDA Tc 99m (p less than 0.01). We conclude that, while the overall differences between these two radiopharmaceuticals are small, diisopropyl-IDA Tc 99m is superior because of a lower renal excretion rate in patients with decreased hepatocyte function.

Bile Duct Diseases↗
PubMed1981

The normal fasting and postprandial diisopropyl-IDA Tc 99m hepatobiliary study.

Diisopropyl-IDA Tc 99m imaging studies were performed in 11 normal subjects in both the fasting and postprandial states. In 5- to 60-minute analog images obtained in both fasting and postprandial studies, the cardiac blood pool was almost never seen, renal pelvic radioactivity was commonly seen, the extrahepatic biliary tract was always seen, and the left hepatic duct was always more prominent than the right hepatic duct. The biliary tract was visualized by ten minutes in nine of 11 fasting studies and 10 of 11 postprandial studies. The gallbladder was visualized in all eleven fasting studies, but in only four postprandial studies. The gallbladder was visualized in all eleven fasting studies, but in only four postprandial studies (p less than 0.05). The zero- to sixty-minute digital data indicated a greater hepatocyte clearance, an earlier time of peak parenchymal radioactivity, and a faster parenchymal washout in the postprandial studies compared with fasting studies (p less than 0.05). Approximately nine percent of the injected dose was recovered in the urine during the first three hours in fasting and postprandial studies. The normal diisopropyl-IDA Tc 99m study in the fasting and postprandial states is defined; significant differences exist between the two states.

Adult↗
PubMed1981

Chemical and biological studies of Tc-99m N,N'-bis(mercaptoacetamido)-ethylenediamine: a potential replacement for I-131 iodohippurate.

The tetradentate chelating agent N,N'-bis(benzoylmercaptoacetamido)ethylenediamine was synthesized for evaluation as a potential technetium-99m renal-function radiopharmaceutical. Complexes were prepared using different reducing agents and analyzed by high-performance liquid chromatography. Biological studies were performed in mice, rats, and rabbits and indicated that the new agent is cleared by the kidneys significantly faster than Tc-99m DTPA (p less than 0.01) and slightly slower than I-131 o-iodohippuric acid (p greater than 0.05). There was no evidence of significant renal retention. Renal excretion in all species studied was 70--75% of the injected dose in 30 min; biliary excretion in rats was 7% in animals with normal renal function and 18% in 90 min in the absence of renal function. We conclude that limited clinical trials are warranted.

Animals↗
PubMed1981

Effect of complete biliary-tract obstruction on serial hepatobiliary imaging in an experimental model: concise communication.

In order to determine the effect of biliary obstruction on hepatocyte clearance and bile flow, five dogs were imaged before, and three times a week after, surgical ligation of the common bile duct. THe first postoperative study was performed 3 hr after surgery. Bile flow and duct function were evaluated from analog images; hepatocyte clearance (HC) was estimated in digital images from the ratio of liver to cardiac blood-pool counts at 3 min. Liver function tests were measured serially. 3 hr after surgery the HC index and liver function tests were still normal. Analog images showed no intestinal radioactivity, but accumulation was seen in the distending biliary tract. on the third postoperative day, all liver function tests were abnormal and the HC index was significantly decreased (p less than 0.01). The biliary tract was never seen beyond the first postoperative day. Thus, complete obstruction of the common bile duct does not stop bile flow or cause significant hepatocyte damage in the first few hours. By the third day of obstruction, however, no bile flow is detectible and significant hepatocyte damage has occurred.

Alanine Transaminase↗
PubMed1980

Communication of intrahepatic cavities with bile ducts: demonstration with Tc-99m-diethyl-IDA imaging.

Tc-99m-diethyl-IDA imaging demonstrated intrahepatic bile leaks in two patients. The first patient had an intrahepatic abscess associated with a common bile duct stone; he was successfully treated with common duct lithotomy and antibiotics, but without surgical drainage of the intrahepatic abscess. The second patient had bile leakage into an intrahepatic cavitary hematoma after abdominal trauma.

Adolescent↗
PubMed1980

Failure of low doses of 131I to ablate residual thyroid tissue following surgery for thyroid cancer.

Thirteen patients received an initial dose of 25-29.9 mCi (9259-1, 106 MB1) of 131I following partial thyroidectomy for papillary, follicular, or mixed carcinoma. Administration of thyroxine (T4) or triiodothyronine (T3) was stopped 3-12 weeks and 1-6 weeks, respectively, before therapy or imaging. Patients remained on normal diets and did not receive thyroid-stimulating hormone (TSH) or diuretics. Follow-up 3 months to 2 years after therapy demonstrated that ablation of thyroid bed activity was successful in only one patient, who still had metastases. This suggests that administration of 25-29.9 mCi of 131I following surgery is unreliable for ablation of residual thyroid bed activity.

Adenocarcinoma↗
PubMed1979

Renal uptake of 99mTc-sulfur colloid in liver transplant patients.

There was renal uptake of 99mTc-sulfur colloid in liver-spleen studies performed on three liver transplant patients. Unlike all previously reported patients, none was in congestive heart failure. The mechanism of this uptake is unknown, but in our three patients it did not correlate with hepatic or renal function.

Adult↗
PubMed1978

Simple computer method for equivalent square therapy field determination.

A simple BASIC computer program allows rapid determination of the equivalent squares of irregular radiation therapy fields. A port film or scale drawing of the irregular field is outlined manually on a spark tablet digitizer, and the side length of the square of equivalent area to perimeter ratio is rapidly calculated and returned by the computer.

Computers↗
PubMed1975

Lack of effect of vitamin A on differentiation in squamous carcinoma.

High oral doses of vitamin A given to Irish rats bearing squamous carcinomas failed to produce detectable light level histologic change in the tumors. The cell line was grown in tissue culture with and without vitamin A; electron-microscopic examination failed to reveal significant differences between experimental and control cultures.

Animals↗
PubMedDate not supplied

A new apparatus for the localization of nonpalpable mammary lesions.

A new apparatus has been used for the localization of 46 nonpalpable mammary lesions seen in either of two radiological projections. This device compresses and immobilizes the breast independently of the mammography equipment and permits a three-dimensional localization of the lesion by using the technique of X-ray angulation. The results demonstrate the efficiency of the procedure. Transfixation of the lesions was established in 30 cases (65.2%), the guidewire passed very close to the lesion in 14 cases (30.4%), and in 2 cases (4.4%) the guidewire was seen to be less than 10 mm away from the lesion. Correct preoperative localization of the lesions permitted a correct diagnosis with minimal biopsies.

Adult↗
PubMedDate not supplied

Mammography in the 1990s: a plea for objective doctors and informed patients.

Mammography screening is increasingly promoted as a means to avoid death from breast cancer. Although some randomized trials have shown a mortality benefit in the older screened groups, not all the results have been statistically significant; benefit has not been shown in younger age groups. Mammography detects smaller lesions than physical examination, but the only randomized trial comparing the mortality benefits of mammography and physical examination shows no benefit for mammography. The systemic nature of breast cancer raises questions about the theoretical mortality benefit of screening. Patients undergoing mammography may experience unexpected anxiety about the results. Candidates for screening should be routinely informed of these issues.

Adult↗