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Biomedical subjects

C C Harris

Publications and source records attributed to C C Harris.

At least 433 records · Page 24Linked to original sources
PubMed1975

Immunosuppressive anticancer drugs in man: their oncogenic potential.

As therapy of cancer becomes more sucessful, the number of long-term survivors is increasing. In addition, cancer chemotherapeutic drugs are being used as immunosuppressive agents in the chronic treatment of non-neoplastic diseases. The long-range hazards of therapy are a serious consideration in these two groups of patients. This brief review examines the potential oncogenic as well as co-oncogenic hazards of cancer chemotherapy in man. Many of these drugs are oncogenic and/or co-oncogenic in experimental animals.

Antineoplastic Agents↗
PubMed1975

Oncogenesis and other late effects of cancer treatment in children.

Review of hospital charts of 168 patients surviving two or more years following the diagnosis of cancer and subsequent-examinations of 40 of these patients yielded these observations: (a) Hospital charts were adequate to ascertain the number of second primary neoplasms. Three malignant and eight benign tumors were found, an incidence of 6.5%. (b) The three patients with second malignant neoplasms did not receive chemotherapy and two of three were treated with radiation. (c) Abnormalities other than second neoplasms, which may have been delayed consequences of treatment, were infrequently noted in hospital records, but were subsequently detected on specific examinations.

Antineoplastic Agents↗
PubMed1975

Quantitative light microscopic autoradiography. Emulsion sensitivity and latent image fading.

Emulsion sensitivity, latent image fading, and the effects of temperature, humidity, radiation dose and chemography on them were measured for NTB2 autoradiographic emulsion using quantitative methods. Sensitivity of NTB2 emulsion increased as the temperature during exposure increased, with the greatest increase per degree occurring between -20 degrees C. At 4 degrees C, emulsion sensitivity remained constant with time and radiation dose. Direct measurement of latent image fading showed no latent image fading for 60 weeks on slides exposed at 4 degrees C with Drierite. Slides exposed at 27 degrees C showed significant latent image fading and great variation between samples. High humidity decreased emulsion sensitivity and increased latent image fading. No evidence of either positive or negative chemography was found. The practical use of autoradiography requires an internal standard on each slide to correct for fluctuations in temperature and humidity during exposure time.

Autoradiography↗