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Biomedical subjects

C C Church

Publications and source records attributed to C C Church.

28 records · Page 2Linked to original sources

Erratum: transient pulsations of small gas bubbles in water [J. Acoust. Soc. Am. 84, 985-998 (1988)] [corrected and republished].

Transient behavior of small gas bubbles in a liquid set into violent motion by ultrasonic pressure waves is of interest because of widespread use of microsecond pulses in diagnostic ultrasound. Such pulses contain only a few pressure cycles and the transient pulsations of bubbles set in motion by such pulses would determine the bubble-ultrasound interaction. A computer study has been made to obtain a global representation of the pulsation amplitudes R (t) of small gas bubbles (nuclei) in water during the first few cycles of a cw ultrasonic pressure. One objective was to obtain a better understanding of cavitation phenomena where many nuclei with initial radii Rn from 0.1-20 microns are set in motion at pressures ranging from 0.5-5 bars and at frequencies from 0.5-10 MHz. Results allowed construction of surfaces showing the relative bubble amplitude R/Rn as a function of Rn and of the time t/TA, where TA is the acoustic period. One finding is that, in the range of peak pressures found in diagnostic pulses, transient cavities would be generated during the first pressure cycle from nuclei with initial radii as small as a few microns (micron). Nuclei that grow into transient cavities in the first pressure cycle are here called "prompt" nuclei. At a specified pressure, the size range of radii Rn in which they occur decreases with increasing frequency. At 5 bars, the range of Rn for prompt nuclei is 0.166-11.35 microns at 0.5 MHz and vanishes at 10 MHz.

Gases↗

A mechanism for the generation of cavitation maxima by pulsed ultrasound.

A train of 1-MHz pulses can generate maxima of cavitation activity [V. Ciaravino, H. G. Flynn, and M. W. Miller, Ultrasound Med. Biol. 7, 159-166 (1981)] at pulse lengths of 6 and 60 ms and at pressure amplitudes, PA, between 5.4 and 9.4 bars (or intensities between 10 and 30 W/cm2). Generation of maxima at PA between these limits on pressure amplitude implies that the increase in cavitation activity originates from gas nuclei with radii lying in a critical size range centered at about 0.08 micron. The mechanism proposed for this phenomenon suggests that nuclei in this critical range are unstabilized nuclei generated in one pulse and surviving to the next with an appreciable fraction of the survivors lying in the critical range. Transient cavities that grow from such small nuclei are shown to behave as isolated mechanical systems that on reaching maximum size collapse as imploding spheres. The maximum pressures reached in such imploding cavities would then approximate those calculated for the spherical collapse of cavities. The occurrence of the observed maxima is ascribed to the spherical collapse of transient cavities.

Acoustics↗

The exposure vessel as a factor in ultrasonically-induced mammalian cell lysis--II. An explanation of the need to rotate exposure tubes.

This paper is an attempt to explain the need to rotate a polystyrene tube containing a cell suspension in order to obtain cell lysis. Calculations, based on known physical laws, were performed in order to determine the important forces on cells and bubbles and the movements and interactions which these forces are likely to cause. These calculations support the following conclusions: (1) in the absence of rotation, cells and bubbles larger than resonance size are trapped at pressure minima while bubbles smaller than resonance size are trapped at pressure maxima, (2) at 1 W/cm2 with rotation, lysis is caused by cells sweeping through arrays of trapped small bubbles, (3) at higher intensities lysis is caused by both trapped and non-trapped small bubbles.

Animals↗

Radiographic diagnosis of acute peroneal tendon dislocation.

Acute dislocation of the peroneal tendons at the ankle is accompanied, in a significant proportion of cases, by a characteristic small shelllike avulsion fracture of the lateral malleolus, rendering the lesion diagnosable radiographically. This small fracture is usually best seen on internal rotation oblique or occasionally on anteroposterior films of the ankle. It is seen as a bone flake only a few millimeters thick but often 1 cm or more in vertical diameter lying adjacent to the posterolateral surface of the lateral malleolus. It is an infrequent injury, now usually the result of a ski accident. Failure to recognize and treat the lesion can result in chronic disability.

Acute Disease↗

The kinetics and mechanics of ultrasonically-induced cell lysis produced by non-trapped bubbles in a rotating culture tube.

The kinetics of ultrasonically-induced cell lysis are examined in terms of classical radiation biology target theory. A theoretical expression relating the concentration of intact cells remaining after a given period of sonication in a rotating culture tube to the number of non-trapped bubbles, l, which a cell must encounter in order to be lysed is obtained. The expression is compared to experimental results in order to determine the actual value of l. It is found that l equals one (1). The concentration of non-trapped bubbles which is responsible for the observed cell lysis is calculated to be 250-500 cm-3. Finally, it is proposed that non-trapped bubbles tunnel into cells while undergoing stable cavitation and that cell lysis is produced by one or more transient events inside the cell.

Animals↗

The high-functioning autistic experience: birth to preteen years.

A retrospective chart review of 15 children with high-functioning autism was conducted for the years 1981 through 1992. The purpose of the study was to describe the experience of children with high-functioning autism from infancy through preadolescence. Chart data included clinic staff records, parent letters, academic program records, service records, and comments from the children themselves. The findings of this study support the proposition that children with autism who have an IQ above 70 follow a varied but improving course over time. All 15 children met the DSM-III-R criteria for autism when first evaluated. By middle elementary school, however, none of the children in this study met the DSM-III-R criteria for autism, although they continued to have various language disturbances, social skill deficits, and unique behavioral qualities.

Adaptation, Psychological↗

A comprehensive, multidisciplinary approach to providing health care for children in out-of-home care.

Every community has children placed in the out-of-home care system. Despite a high prevalence of health, mental health, and developmental morbidity in children in care, most child welfare agencies have not provided adequate diagnostic and therapeutic services for these children. A comprehensive, multidisciplinary clinic for children in out-of-home care involving pediatrics, child psychology, nursing, child development, and child welfare is described. Profiles of the health, mental health, and developmental status of the children in out-of-home care are also presented.

Child↗

Home-based developmental screening of children in foster care.

Children in foster care have a high prevalence of developmental delay. A program for developmental screening was designed to address the increased risk of developmental delay among children in foster care. Fifty-two children birth to 18 months were evaluated using the Denver Developmental Screening Test-II (DDST-II), Early Language Milestone Scale-2 (ELM-2), and the HOME Scale. Forty-nine children were screened with the Infant Neurological International Battery. Thirty five percent of the children failed DDST-II screening. Language assessment with the ELM-2 resulted in a mean global ELM-2 standard score of 89. Sixty-one percent of children had abnormal neurologic INFANIB screening exams. HOME scores reflected foster care environments that provided adequate developmental and emotional stimulation for the children. Implications for future interventions should move from developmental screening to comprehensive developmental testing and expansion of foster parent education regarding the growth and development of the foster children in their care.

Community Health Nursing↗