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Biomedical subjects

C C Carson

Publications and source records attributed to C C Carson.

135 records · Page 8Linked to original sources
PubMed1979

Clinical importance of microhematuria.

To evaluate the etiology of microhematuria, the cases of 200 consecutive patients with asymptomatic microhematuria who had undergone complete urologic examination and two-year follow-up were reviewed. Most patients were 50 to 59 years old. Highly significant urologic lesions were found in 20% of patients. Thirteen percent of these patients had a genitourinary malignant neoplasm. No urologic lesion could be identified in 19% of patients in this group. The results suggest that present diagnostic modalities have substantially refined and improved the urologist's diagnostic abilities. The urologic examination of patients with asymptomatic microhematuria, particularly in those older than 40 years, is justified.

Age Factors↗
PubMed1979

Psychologic characteristics of patients with female urethral syndrome.

Numerous investigations have been conducted in an effort to determine the cause of the female urethral syndrome. Bacterial and anatomic causes rarely have been identified. Using the MMPI, we evaluated 56 women with thus syndrome and compared them with control patients of similar ages. Statistically significant increases in the F, hysteria, hypochondriasis, and schizophrenia scales were found in the patients with the female urethral syndrome. These scores suggest the presence of a psychophysiologic process in these patients.

Adult↗
PubMed1978

Urologic aspects of vesicoenteric fistulas.

The classic symptoms of pneumaturia and fecaluria were not present in many of 100 patients (male to female ratio of 2.4) with vesicoenteric fistulas who presented with fever, abdominal mass or cystitis. There was a urinary tract infection in 95 per cent of the patients studied but only 29 per cent had a mixed infection. Roentgenographic studies suggested a fistula in 18 to 35 per cent of those studied but cystoscopy was singularly the most successful diagnostic technique (79 per cent). Inflammatory bowel disease in 63 per cent and colorectal adenocarcinoma in 16 per cent were the most common etiologic factors. Bladder carcinoma was the cause in only 5 per cent. Treatment consisted of single or multistage surgical repair of fecal diversion in 95 operable patients, with gratifying results, and of expectant management in the 5 inoperable patients.

Adenocarcinoma↗
PubMedDate not supplied

Bladder function in female rats: effects of aging and pregnancy.

In vivo anesthetized cystometrograms and in vitro bladder tissue strip responses were examined in three groups of female rats: young virgins (3 month), older virgins (8 month), and retired breeders (8-9 month). Significant age-related in vivo changes were observed including greater resting pressures, but smaller voided volumes, void durations and void-to-void intervals in older versus young virgin rats. There were significant age-related changes in the in vitro responses. Greater peak and steady state contractions to high K+-modified Krebs (80 mM) depolarization were observed in young animals compared to older animals. Plus, young virgins exhibited greater sensitivity but smaller maximal, normalized contractions to acetylcholine (ACh) than older virgins. Diminished responses to adenosine-5'-triphosphate (ATP) were detected in young versus older virgin rats. Pregnancy-related changes were compared between retired breeders and their age-matched controls, older virgin rats. In vivo voided volumes were greater in the retired breeders than in the older virgins. Smaller in vitro steady state contractions to high K+-modified Krebs depolarization and smaller normalized contractions to maximal concentrations of ACh were observed in the retired breeders than in the older virgins. Retired breeders exhibited diminished relaxation responses to norepinephrine compared to older virgins. ATP produced greater dose-dependent responses and greater maximal contractions in the retired breeders compared to the older virgins. In conclusion, age-related changes were present even prior to the onset of senescence, and multiple pregnancies altered bladder function.

Aging↗
PubMedDate not supplied

The effect of vasoactive intestinal polypeptide (VIP) on rabbit cavernosal smooth muscle contractility.

Vasoactive intestinal polypeptide (VIP) has emerged as a possible candidate for a nonadrenergic, noncholinergic inhibitory neurotransmitter in penile erection. In this study, the effect of VIP and its relationship to the adrenergic and cholinergic mechanisms were examined using isolated corpus cavernosal strips from the rabbit penis. The mechanism of action of VIP on corporal relaxation was investigated with respect to the activation of cyclic GMP and the mobilization of calcium and potassium ions. VIP caused a dose-dependent relaxation of the cavernosal strip. Pretreatment with VIP had no effect on the contraction induced by norepinephrine, phenylephrine, and clonidine. VIP had no synergistic effect on the relaxation produced by acetylcholine or isoproterenol. Neither atropine nor propranolol had any blocking effect on the VIP-induced relaxation. Methylene blue decreased the VIP-induced relaxation of the cavernosal strip. VIP had no effect on the contraction induced by KCl at either 20 or 80 mM. In calcium-free high-potassium physiologic salt solution, VIP inhibited the calcium-induced contraction. These results suggests that the mechanism of action of VIP is not mediated through classical adrenergic and cholinergic neurotransmission on rabbit cavernosal strips, but that VIP may exert its action by the activation of cyclic GMP, which may be associated, in part, with the inhibition of calcium influx.

Animals↗