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Biomedical subjects

C C Booth

Publications and source records attributed to C C Booth.

At least 19 recordsLinked to original sources

The British Medical Bulletin 1943-1993. A guide to medical science and thought in Britain.

Established 50 years ago by The British Council, to promote medical science abroad, the British Medical Bulletin (BMB) has evolved from a stencilled list of abstracts into a distinguished medical periodical. It has reflected the extraordinary diversity of advances that have been made in medicine in this country. During these 5 decades anti-microbial chemotherapy has become firmly established; organ and tissue transplantation have become a reality; the significance of Watson and Crick's discovery of the structure of DNA has been realised by the increasing applications of molecular biology to human disease; and modern investigative techniques, particularly magnetic resonance imaging, have made the human body virtually transparent. At the same time the BMB has mirrored fresh concerns, with, for example, industrial and environmental hazards, with newly recognised infectious agents, and increasingly with the medico-social problems of the modern era. This paper reviews the scientific contributions of the Bulletin and some of the administrative and financial structures that have supported it.

History, 20th Century

Buffering of intracellular calcium in response to increased extracellular levels in mortal, immortal, and transformed human breast epithelial cells.

Extracellular levels of calcium at 1.05 mM or higher induce terminal differentiation and senescence in the mortal (MCF-10M) line of human breast epithelial cells, but does not retard the growth or induce differentiation in the immortal (MCF-10A) and oncogene transformed (MCF-10AneoT) lines. Intracellular levels of calcium and inositol triphosphate were determined in MCF-10M, MCF-10A, and MCF-10AneoT, under conditions of low and high extracellular calcium. We hereby report that increases in extracellular calcium is translated into significant increases in intracellular levels of calcium and inositol triphosphate in MCF-10M, but not in MCF-10A and MCF-10AneoT. This difference in the apparent calcium buffering capacity between the mortal and the immortalized human breast epithelial cells could account for the latter's unperturbed growth potential in high extracellular calcium environment.

Breast

Rediscoveries.

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History, 18th Century

Coeliac disease and malignancy.

Patients with coeliac disease are at greater risk than the general population for the development of malignant neoplasms, particularly lymphomas. Of 259 histologically confirmed malignancies in 235 patients with histologically proven coeliac disease, 133 were malignant lymphomas, the predominant histological type being malignant histiocytosis and the commonest site of this lesion the small intestine. Patients with coeliac disease also have a greatly increased risk for the development of small-intestinal adenocarcinomas. Among 116 invasive non-lymphomatous malignancies there were 19 small-intestinal adenocarcinomas, compared with 0 . 23 expected from national cancer registrations adjusted for sex and age. There were also more oesophageal and pharyngeal squamous carcinomas than expected.

Adenocarcinoma

HLA antigens in coeliac disease associated with malignancy.

Coeliac patients are at greater risk than the general population of developing malignant neoplasms, particularly lymphomas. The establishment at the Clinical Research Centre of a national collaborative study of coeliac patients with malignancy provided the opportunity to carry out HLA typing for 55 HLA-A, B and C and the 10 recognised DR antigens on a group of coeliac patients with malignancy. Study of a sample of 44 patients with biopsy proven coeliac disease and histologically confirmed malignancy, including 12 with malignant histiocytosis, and 57 coeliac patients without malignancy, failed to show any significant differences in antigen frequencies between patients with and without malignancy. These results indicate that there are no HLA genetic markers associated specifically with the development of malignancy in coeliac disease.

Adult