Biomedical subjects
Publications and source records attributed to C C Barr.
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A 27-year-old man with a history of intravenous-narcotic abuse presented with signs and symptoms suggesting fungal endophthalmitis. He underwent core vitrectomy with intravitreal injection of amphotericin B. Aspergillus flavus grew from cultures of the vitreous aspirate. There was no evidence of extraocular infection, and the patient was treated postoperatively with subconjunctival amphotericin B and oral flucytosine. Unlike previously reported cases of endogenous aspergillus endophthalmitis in drug abusers, the patient described here recovered normal visual acuity.
A 28-year-old woman noted decreased vision in one eye and was found to have bilateral optic disc swelling, periphlebitis, focal chorioretinitis, and vitritis. Subsequent lymph node biopsy revealed nodular sclerosing. Hodgkin's disease, stage II-A. The ocular manifestations of the disease resolved in response to systemic radiation therapy. The relationship of the ophthalmic findings to the systemic disease are discussed.
Voluntary control of the human vestibulo-ocular reflex with and without visual targets was investigated. Subjects were rotated sinusoidally from 0.1 to 1.0 Hz using d.c. electro-oculography to record eye position. The ratio of eye to head movement, or gain, of the vestibulo-ocular reflex was measured. When subjects were rotated in the dark at 0.3 Hz whilst performing mental arithmetic the gain was 0.65. When subjects were asked to fixate imaginary targets in the dark that were stationary in space, the gain rose to 0.95. When they imagined targets rotating with them on the chair, the gain dropped to 0.35. Our results indicate that the ability to modulate the gain of the vestibulo-ocular reflex does not depend entirely on the smooth pursuit system. Higher centers must modulate eye velocity so that it is appropriate to the subject's choice of a frame of reference, whether or not vision is available.
Four patients with primary intraocular reticulum-cell sarcoma were presented. All of the patients were followed at the Wilmer Institute for periods of up to ten years. All had decreased visual acuity and a uveitis that was refractory to standard forms of therapy. In one case, the correct diagnosis was made clinically. At autopsy, two of the patients had systemic reticulum-cell sarcoma, a third had intracranial reticulum-cell sarcoma, and in a fourth case the disease process was confined to the eye. The literature is reviewed and the clinico-pathologic features of the total of 14 cases are analyzed. It is emphasized that a recalcitrant uveitis was present in almost all of the cases reported. Differential diagnosis and methods of diagnosis are discussed.