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Biomedical subjects

C C Alevizaki

Publications and source records attributed to C C Alevizaki.

12 recordsLinked to original sources
PubMed1985

Radioiodine-131 treatment of thyrotoxicosis: dose required for and some factors affecting the early induction of hypothyroidism.

The results of sodium iodide 131I treatment of thyrotoxicosis in 1,168 patients (302 males, 866 females; 58.5% diffuse and 41.5% multinodular toxic goitre) are presented. At the end of the 1st year post-treatment, 54.4% were hypothyroid, and the incidence of hypothyroidism after the 2nd year increased by 3% per year. When the results were analysed according to the calculated radiation dose the thyroid, it was found that the cumulative incidence of hypothyroidism from 6 months to 2 years post-treatment rose almost proportionally to the dose in cases of doses of 1,500-15,000 rad, but increased very little for higher doses; however, the long-term incidence of hypothyroidism was almost independent of the thyroid dose. Multivariate analysis showed that the results of 131I therapy at 6 months depended also on sex (treatment being more effective in women), the consistency of the thyroid gland and the year of treatment, with the same radiation dose giving a higher incidence of hypothyroidism in patients treated recently, in comparison to those treated early in the period studied. Of the patients treated in the period 1978-1982 (mean dose, 300 microCi/g), 93.5% were cured with a single dose of 131I, and 78% were hypothyroid at 6 months post-treatment.

Adult↗
PubMed1983

Volume of sella turcica in normals and patients with peripheral endocrinopathies or idiopathic gonadotropin deficiency.

The volume of sella turcica (VST) was estimated from x-ray films in i) 883 control subjects (507 men and 376 women), ii) 135 adult patients with peripheral endocrine gland insufficiences (71 of the thyroid, 15 of the adrenals and 49 of the gonads) and iii) 41 adult patients with idiopathic gonadotropin deficiency. The mean VST value of men (1356 +/- 22 mm3) was significantly lower (p less than 0.05) than that of women (1428 +/- 25 mm3). This difference resulted from a progressive increase of VST in women after the age of 45 (r = 0.254, p less than 0.001); the mean VST value of women aged less than 45 years (1301 +/- 33 mm3) been similar to that of men (p less than 0.05). VST was significantly (p less than 0.001) increased in peripheral endocrine insufficiences, this increase varying approximately between + 30% and + 55% of the mean volume of normals according to the endocrinopathy. Definitely abnormal sella turcica (VST larger than + 2SD) were observed in a percentage smaller than 27% of the cases in all groups. Furthermore, the increase in VST was significantly related to the severity of the disease in primary hypothyroidism (p less than 0.001) and the duration of the abnormal condition in Addison's disease and primary gonadal failure (p less than 0.001). Finally, VST was found within normal limits in patients with idiopathic gonadotropin deficiency. It is concluded that natural (menopause) or pathological peripheral endocrine insufficiency leads to VST enlargement which exceeds the upper normal limits in less than 27% of the cases.

Addison Disease↗
PubMed1979

Partial reversal of the defect in intestinal calcium absorption during the course of regular hemodialysis.

The coefficient of true intestinal calcium absorption (a value) was measured by a double radioisotope technique in 24 patients treated by regular hemodialysis for 2--46 months. The mean a value of these patients was significantly below normal (p less than 0.001). 18 of them were studied a second time after an interval of 12 months. Values at 12 months were higher than the corresponding initial values (p less than 0.001). There was a trend to higher a values in the patients treated for longer periods of time. It is concluded that the defect in calcium absorption tends to reverse during the course of regular hemodialysis.

Adolescent↗
PubMed1979

Scintigraphic detection of gynaecological tumours by 99mTc-HSA blood pool imaging.

Three cases of scintigraphic visualization of gynaecological tumours by 99mTc-HSA blood pool imaging are presented, i.e. one case of fibrothecoma ("cold" area visualization) and two cases of fibromyoma ("hot" area visualization). It is suggested that this technique may be useful in the preoperative evaluation of gynaecological tumours and their vascularity.

Adult↗
PubMed1976

Relationship between degree of renal failure and impairment of intestinal calcium absorption.

The coefficient of true intestinal calcium absorption (a value) was measured by a double radioisotope technique in 29 chronic renal failure patients (serum creatinine levles 2.5-19.5 mg%) aged 20-75 years. The mean log 10 a (+/- standard error) of these subjects (1.197 +/- 0.031) was significantly lower (p less than 0.001) than that of 52 controls (1.532 +/- 0.024), the geometric mean of the renal failure group (15.7%) being approximately half (46%) of that of the controls (33.9%). The decrease of a value of the uremic patients was more pronounced in the younger than in the older subjects as shown by a statistically significant (r = 0.570; p less than 0.001) positive curvilinear, relationship between a value and age. The lowest intestinal calcium absorptions were observed in patients with a serum creatinine level of approximately 11 mg%, the a values increasing progressively with lower or larger than 11 mg% serum creatinine levels, as shown by a statistically significant (r = 0.485; p less than 0.01) parabolic relationship between a value and serum creatinine. The possible mechanism(s) of this relationship are discussed.

Adult↗