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Biomedical subjects

C Bunnag

Publications and source records attributed to C Bunnag.

At least 19 recordsLinked to original sources
PubMed2001

Allergic conjunctivitis.

The purpose of this research is to study the clinical features and risk factors of various types of allergic conjunctivitis. Four hundred and forty-five patients with a history of itching, foreign body sensation, lacrimation and red eyes were examined, and a skin test was performed and assessed to grade the severity. The mean age of the subjects was 24.5 +/- 16.3 years with female preponderance, except for vernal keratoconjunctivitis. The majority of the patients had perennial allergic conjunctivitis. Ninety-five percent of the patients had associated allergic diseases, especially allergic rhinitis. Sixty-six percent of the patients had a family history of atopy. Most patients had symptoms at night. Symptoms persisted throughout the year and were generally triggered by exposure to house dust. The allergy skin tests to common aero-allergens were positive in 95% of patients tested. Common allergens causing sensitization were house-dust mites, house dust, cockroaches, and grass pollen. Environmental control and avoidance of these allergens should be stressed in the management of these conditions.

Adolescent↗
PubMed2000

A non-comparative trial of the efficacy and safety of fexofenadine for treatment of perennial allergic rhinitis.

An open-label, non-comparative study was performed in three Otolaryngology centers in Bangkok, Thailand, to assess the efficacy, safety and tolerability of fexofenadine in Thai patients with perennial allergic rhinitis. Altogether 101 perennial allergic rhinitis patients were included, 33 males and 68 females. Mean age was 33 years, average duration of symptoms was 6 years. All patients received fexofenadine hydrochloride 120 mg once daily (OD) in the morning for 2 weeks. Patients recorded their allergy symptoms daily using a 5 point rating scales in the diary card. At the end of 2 weeks, patients and investigators assessed the overall efficacy of treatment. Adverse events and onset of symptom relief were also recorded by every patient. Blood test and ECG were performed before and after treatment in one center (Siriraj Hospital). Total symptom scores and nasal scores decreased significantly from a baseline at 1 week and 2 weeks after treatment (p < 0.05). The mean onset of symptom relief was 2 hours and 12 minutes. The global assessment of the treatment by patients and investigators showed significant concordance. There was no significant change in either the vital signs, laboratory tests or ECG. The incidence of treatment related adverse events was 8% but all were mild and easily tolerated. Drowsiness was reported from only one patient. This study suggests that fexofenadine 120 mg once daily was an effective, safe and well tolerated treatment for perennial allergic rhinitis in Thai patients.

Adolescent↗
PubMed2000

Epidemiology of rhinitis in Thais: characteristics and risk factors.

A questionnaire survey was performed on 3,124 subjects living in Bangkok and its vicinity. The cumulative prevalence of chronic rhinitis (CR) was 13.15% (95% CI = 13.13-13.17). The characteristics of CR subjects, i.e. age group, current occupation, associated allergy, family history of atopy, cigarette smoking and drinking habits were totally different from the non CR group, except for sex preponderance. The possible risk factors for developing CR in this group were high income occupation, presence of associated allergy, family history of atopy, smoking and drinking habits. When CR subjects were further classified into "allergic" and "non-allergic" CR groups by using the presence of associated eye symptoms and known provoking factors as the differential criteria, there was no significant difference in all parameters compared between the two groups, i.e. age, sex, current occupation, associated allergy, family history of atopy, smoking and drinking habits, frequency of occurrence of each nasal symptom, seasonal variation of the symptoms, effect of moving to live in the big city, presence of pets in the house and effect of changing occupation, except for the number of nasal symptoms which was significantly higher in the "allergic" CR group.

Adolescent↗
PubMed1999

Characteristics of atrophic rhinitis in Thai patients at the Siriraj Hospital.

The common characteristics of primary atrophic rhinitis were studied in 46 Thai patients. From history and demographic data the female to male ratio was found to be 5.6 to 1. The significance of environmental factors was supported by the findings that 69.6% were people from rural areas and 43.5% were industrial workers but a hereditary factor has not been confirmed. The results of the blood tests did not elucidate iron deficiency anemia or nutritional deficiency as the cause of primary atrophic rhinitis. However, all nasal swab cultures yielded pathogenic organisms where Klebsiella species especially, K. ozaena, were the most common bacteria isolated which were 100% susceptible to cephalosporins. This finding together with the evidence of sinusitis seen in 58.7% of either plain x-rays or CT scans, was suggestive of the important role of infection in atrophic rhinitis. Atrophic change of the mucosa and bone with widening of the nasal cavity were constant findings in the CT scans but the developmental anomaly of the maxillary antrum was found in only 15.2%. The histological study showed characteristic changes especially squamous metaplasia and 80% of the cases were compatible with the Type II histopathological classification, i.e. vasodilatation of the capillaries. The mucociliary function was proven to be impaired in accordance with the loss of cilia. The evidence of Type I allergy demonstrated by skin testing, which was obvious in 85%, is highly suggestive of allergic/immunologic disorders. Although many factors have been cited previously as the possible cause of primary atrophic rhinitis, the common characteristics found in our patients indicate that only bacterial infection, environmental factors and allergic/immunologic disorders could be one or more of its multifactorial etiology and should be further investigated.

Adolescent↗
PubMed1999

Nasal endoscopic findings in patients with perennial allergic rhinitis.

Nasal endoscopy was carried out in 83 patients with perennial allergic rhinitis to evaluate endonasal anatomic variation and to find the correlation between the symptoms of patients and the endoscopic findings. All of the patients had nasal symptoms, 7.2% of the patients were runner, 7.2% were blocker and 85.6% were both. 86.75% of the patients had allergy-related symptoms, i.e. throat symptoms (73.5%), sinus headache (50.6%), and smell disturbance (10.8%). 95.2% of patients had abnormal endoscopic findings, i.e. deviated nasal septum (72.3%), abnormal middle turbinate (49.4%), narrowing of the entrance into the frontal recess (30.1%), septal spur (25.3%), obstruction of the entrance into the frontal recess (19.3%), nasal polyps (15.7%), mucopurulent discharge (14.5%), inferior turbinate hypertrophy (10.8%), abnormal uncinate process (9.6%), abnormal ethmoid bullae (7.2%), and enlargement of aggar nasi cells (2.4%). There was no significant correlation between each symptom and each endoscopic finding. However, there was a significant correlation between sinus headache and all of the combined abnormal endoscopic findings (P<0.05). These findings suggested that variations in endonasal anatomy was not by itself a pathology or a cause of symptoms. However, a combination of these variations may narrow the cleft of the ostiomeatal unit and cause contact area or stenosis, which predisposed patients to persistent symptoms, recurrent infection or resistance to therapy in patients with perennial allergic rhinitis. The endoscope might be a very useful tool for allergists, immunologists, and rhinologists, who work in the nose to deal with these cases.

Adolescent↗
PubMed1996

The first naso-sinus laboratory for cadaver preparation in Thailand.

The first naso-sinus laboratory has been set up in Siriraj Hospital for better training of rhinosurgeons. The specimens used for practice operation are the entire nasal cavities with all paranasal sinuses, taken from cadavers and preserved in 95% ethanol. The "Siriraj" sinus holder is specially designed and constructed to hold various sizes of specimens. It is made of plastic board and stainless steel screws; it is an inexpensive and simple device which can be afforded by every centre. With this naso-sinus laboratory, ENT residents and rhinosurgeons can achieve their skills in performing nasal endoscopy, endoscopic or microscopical sinus surgery and all kinds of sinus operations at their convenience.

Cadaver↗
PubMed1992

A double-blind comparison of nasal budesonide and oral astemizole for the treatment of perennial rhinitis.

Sixty-nine outpatients with symptomatic perennial rhinitis were recruited to this double-blind, parallel-group study to compare budesonide nasal spray with oral astemizole. Following a 1-week run-in on placebo, 67 patients achieved a mean daily total symptom score of at least 4 (scoring for each symptom was 0 = none, 1 = mild, 2 = moderate, 3 = severe), and were randomized to study treatments - 33 to budesonide, 100 micrograms in each nostril morning and evening, and 34 to astemizole, one 10-mg tablet each morning, for a period of 4 weeks. No antihistamine preparations other than eye drops and no corticosteroids were permitted during the active treatment period. Patients recorded symptoms of blocked nose, runny nose, sneezing, itchy nose, sore eyes or runny eyes in diary cards each evening before retiring. Diary card data showed that there was significantly greater improvement in blocked nose, runny nose and runny eyes during the first 2 weeks of budesonide treatment than during the same period on astemizole. A similar, although non-significant, trend was observed for sneezing and itchy nose, but there was no apparent difference in the reporting of sore eyes. After 4 weeks, blocked nose and runny nose remained significantly less troublesome in the budesonide group. Both treatments were well-tolerated and no major adverse effects were reported. Patient ratings for treatment efficacy were significantly higher for budesonide than astemizole at both 2 weeks and 4 weeks.

Administration, Topical↗
PubMed1991

Effect of allerglobuline injection on serum immunoglobulin levels in ENT patients.

Allerglobuline is a human gammaglobulin preparation which has been reported to have a protective effect against Type I allergic diseases and chronic infection of the upper respiratory tract both in adults and children. This study included 64 patients suffering from perennial allergic rhinitis and/or chronic infection of the nose, paranasal sinuses and pharynx. All patients received Allerglobuline 10 ml intramuscular injection once a week for 5 times then once a month for another 3 times. Blood samples were taken before the first and after the last injections to assay for the levels of Igs G, A, M and E. The therapeutic responses were evaluated after the fifth injections by dividing into 5 grades (from Grade I = excellent to Grade V = no response). Statistical analysis revealed that there was no significant difference between the pre- and post-treatment levels of Igs, G, A and M. But the level of IgE decreased significantly after 8 injections (p less than 0.001). There was no correlation between the level of immunoglobulins and grade of therapeutic responses. But the number of patients who respond satisfactorily to Allerglobuline treatment increased from 62.26% after 5 injections to 77.36% after 8 injections. This difference does not reach the statistically significant level but is noteworthy.

Adolescent↗
PubMed1989

A preliminary study of circulating immune complexes during allergen immunotherapy in Thai patients.

Circulating immune complexes are suspected as a potentially serious adverse effect after prolonged allergen immunotherapy. This study was undertaken to determine whether there were any significant immunological differences between 32 subjects with allergic rhinitis/asthma treated with immunotherapy of various durations and 13 subjects with similar diagnosis who had never been treated by immunotherapy. All patients were carefully examined for symptoms and signs of immune-complex diseases with negative results. The presence of circulating immune complexes was evaluated by the modified 125I-C1q binding test, the solid phase conglutinin (K) binding test and determination of C3, C4 and C3d levels. In addition, urinalysis, and quantitative determination of serum IgG, IgA, IgM and IgE were also performed. The overall results suggested that prolonged allergen immunotherapy did not result in an increase of circulating immune complexes or other adverse immunological consequences.

Adult↗
PubMed1989

Ferns and their allergenic importance: skin and nasal provocation tests to fern spore extract in allergic and non-allergic patients.

In our recent survey, fern spores were found to be the third most common airborne air spora in the Bangkok atmosphere; therefore, the significance of fern spores as a causative allergen was assessed in patients with allergic rhinitis. By using the extract from the spores of Acrostichum aureum Linn, which is a widespread fern, an intracutaneous test was done in 226 allergic rhinitis patients and 61.5% of these patients reacted positively. Nasal provocation test by using the same kind of fern spore extract was also performed in 24 allergic rhinitis patients and the positive reaction occurred in 70.8%. When skin tests and nasal provocation tests were performed in a group of 20 nonallergic ENT patients, only 20% gave weakly positive skin test reactions and 15% gave mild reactions to the nasal provocation test. The authors concluded that fern spores are potentially allergenic and allergists should be aware that ferns could be an important aeroallergen.

Humans↗
PubMed1988

Intranasal budesonide for the treatment of perennial rhinitis in Thai patients.

The efficacy and tolerability of a new intranasal glucocorticosteroid, budesonide, was evaluated in 28 Thai adult patients with perennial rhinitis. After one week pre-treatment observation period, the nasal spray was given as two puffs into each nostril twice daily (400 micrograms/day) for four weeks. The severity of all nasal symptoms decreased significantly after 1 week treatment reaching a minimal level after 2 weeks. The amounts of antihistamine tablets taken by the patients were also significantly reduced during the treatment with budesonide. Three patients reported adverse effects which were mild and easily tolerated. Morning plasma cortisol levels measured before and after four-week treatment in 15 patients revealed no significant changes. This study suggests that intranasal budesonide is an effective and well-tolerated treatment for perennial rhinitis.

Administration, Intranasal↗
PubMed1984

A study of the skin reaction to bacterial vaccine in perennial rhinitis.

Immediate and late skin reactions to a bacterial vaccine test were studied in perennial rhinitis patients. The incidence of late skin response was 17.6% when 0.1 ml of bacterial vaccine was tested. The incidence of positive immediate reaction was similar to the late reaction but there was no significant association between these two types of reaction. There was no correlation between the skin reaction to bacterial extract and the presence of pathogenic and microflora in the nose and throat of the patient. Statistical analysis also showed that there was no significant correlation between the results of the skin test to bacterial vaccine and to common allergenic extracts.

Adolescent↗
PubMed1983

A study of allergic factor in nasal polyp patients.

Various investigations for allergy were carried out on 57 nasal polyp patients. The majority of them (96.5%) showed positive responses to at least one of the methods used. The results suggest that allergy is a constant feature in the nasal polyp patients but that further investigation is needed before we can state that allergic manifestation contributes to polyp formation. It was also found in this study that 90% of the patients had definite pathological changes on their sinus x-rays. Sinus disease may be either predispose a patient to or result from nasal polyps.

Adolescent↗
PubMed1982

A comparative study of the incidence of indoor and outdoor mold spores in Bangkok, Thailand.

The culture plate method was used in this survey of the indoor and outdoor incidence of the atmospheric molds in Bangkok Metropolis in the year 1977. The over-all sampling showed the prevalence of yeasts, Aspergillus, Hermodendrum and non-sporulated white fungi as the frequency of occurrence; each of them was over 50%. In general the incidence was high in the winter months and low in the rainy season except for Aspergillus, Fusarium and Curvularia which did not decline during the rainy period. Observations indicated that there are only slight differences between the incidence and the types of airborne fungi recovered from the exposed plates in the bedrooms and outside the houses in and around Bangkok Metropolis.

Air Microbiology↗
PubMed1980

Intranasal inhalation of beclomethasone dipropionate in the treatment of perennial rhinitis in adults.

Forty-eight perennial rhinitis patients completed a six weeks' open trial of intranasal beclomethasone dipropionate aerosol. Each received a daily dose of 400 micrograms. Thirty-five responded excellently, seven reported satisfactory improvement and six failed. This study indicated that patients with a demonstrable allergic component responded favorably. However, due to the wide margin of safety the authors suggest that it be tried on the non-infective perennial rhinitis with no demonstrable allergic component as well.

Administration, Intranasal↗