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Biomedical subjects

C Buck

Publications and source records attributed to C Buck.

106 records · Page 6Linked to original sources
PubMed1972

[Vasectomy].

Explore the source record for details and available documents.

Humans↗
PubMed1966

A survey of women graduates from a Canadian medical school.

Information was obtained from 104 of 106 surviving women medical graduates of the University of Western Ontario in a study designed to determine subsequent working careers and related factors. Of those who had graduated six or more years before this study 85% were engaged in medical work (66% full-time and 19% part-time). General practice, psychiatry and preventive medicine were the leading categories of work. Childbearing was the most important determinant of occupational status. Fewer of the women who had borne children were currently engaged in medical work than were either single or childless married women. The apparent contribution of other factors to working status arose from their correlation with child-bearing. Comparison with other studies suggests that the percentage of female graduates doing medical work is substantially higher than in Britain and about the same as in the United States.

Canada↗
PubMedDate not supplied

Increased levels of tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1 beta) in tracheal aspirates of newborns with pneumonia.

Pneumonia is one of the major sites of infection in ventilated newborns. We investigated whether the cytokines IL-1 beta and TNF-alpha are detectable in tracheal aspirates of newborns with pneumonia as a diagnostic marker. All 12 infants with pneumonia had elevated levels of IL-1 beta (range 30-300 pg/ml) and TNF-alpha (range 60-680 pg/ml), whereas control infants (n = 21; respiratory distress syndrome, very low birth weight or infants intubated preoperatively) had no detectable levels of IL-1 beta or TNF-alpha. In vitro investigations with mononuclear cells of umbilical cord blood were performed to rule out that exogenously added surfactant influences IL-1 beta and TNF-alpha production. It is concluded that IL-1 beta and TNF-alpha are important and specific mediators of neonatal pneumonia which may be of diagnostic importance.

Biomarkers↗
PubMedDate not supplied

Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage.

Many observations suggest the presence of transmembrane linkages between the cytoskeleton and the extracellular matrix. In fibroblasts both light and electron microscopic observations reveal a co-alignment between actin filaments at the cell surface and extracellular fibronectin. These associations are seen at sites of cell matrix interaction, frequently along stress fibres and sometimes where these bundles of microfilaments terminate at adhesion plaques (focal contacts). Non-morphological evidence also indicates a functional linkage between the cytoskeleton and extracellular matrix. Addition of fibronectin to transformed cells induces flattening of the cells and a reorganization of the actin cytoskeleton, with the concomitant appearance of arrays of stress fibres. Conversely, disruption of the actin cytoskeleton by treatment with cytochalasin B leads to release of fibronectin from the cell surface. As yet, there is no detailed knowledge of the molecules involved in this transmembrane linkage, although several proteins have been suggested as candidates in the chain of attachment between bundles of actin filaments and the cytoplasmic face of the plasma membrane: these include vinculin, alpha-actinin and talin, each one having been identified at regions where bundles of actin filaments interact with the plasma membrane and underlying cell-surface fibronectin. Recently, the cell-substrate attachment (CSAT) antigen has been identified as a plasma membrane receptor for fibronectin, raising the possibility that this glycoprotein complex may serve as a bridge between fibronectin and one or more of the underlying cytoskeletal components mentioned. Here we have investigated the interaction of the purified CSAT antigen with these cytoskeletal components, and we demonstrate an interaction specifically between the CSAT antigen and talin.

Animals↗