Implement control measures with process surveillance.
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Biomedical subjects
Publications and source records attributed to C Bryan.
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Severity and frequency of occurrence methods of scoring the Adaptive Behavior Scale, Part Two, were compared using ratings for seven groups of mentally retarded persons. Comparisons involved separately correlating the two methods with independently obtained clinical impressions of symptomatology. The severity scoring system predicted approximately 11 percent more of the variance in the criterion than did frequency scores. These results provide considerable construct and predictive validity for the severity scoring system.
Twelve rhesus monkeys were delivered prematurely at 129, 130, or 131 days. The first breath was inhibited while tracheotomy was performed and a catheter introduced into the umbilical artery. Into the tracheal tubes of six of the newborn monkeys was instilled 0.20 to 0.27 ml. of a natural surfactant (SA) suspension, obtained from lung wash of adult rabbits. Nothing was given to six control monkeys. Breathing was then supported with a ventilator. Although its settings were adjusted in attempts to maintain normal blood gases, the control monkeys developed severe hypercapnia and acidosis, and two died after 4 1/2 and 5 1/2 hours. The remaining four control monkeys and the six treated monkeys were killed after six hours. Pulmonary pressure-volume characteristics were conspicuously better following SA treatment. It was concluded that instillation of SA in the upper airways of premature primates prior to their first breath holds promise as an effective way of preventing respiratory distress.
Gliosis is increased in the respiratory control area of the brainstem in victims of sudden infant death syndrome (SIDS), as it is in infants who have died of congenital heart disease. In the latter, the lesions appear to result from hypoxia or ischemia, and studies of the brainstem microvasculature of SIDS victims indicated a close relationship between the gliosis and adjacent vasculature. It is postulated that cerebral hypoperfusion may play a role in SIDS.
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Campylobacter jejuni has been recognized as a frequent cause of bacterial diarrhea in infants and children. C. jejuni is a fastidious, Gram-negative, comma-shaped or sea gull-shaped, curved rod which is capable, particularly during the summer months, of causing slimy mucoid, blood diarrhea, abdominal pain and fever. In our pediatric office laboratory we found over a 12-month period that 14 (10%) of 126 stool specimens contained this pathogen. All but two children were diagnosed during the late spring and summer. There was no common source for Campylobacter infections in the patients. In 8 (66%) of 12 patients, C. jejuni infection was immediately detected by examining a 1% aqueous basic fuchsin-stained stool smear. Uncontrolled observations from this study suggest that erythromycin therapy, if started within 2 to 3 days of the onset of illness, is clinically effective.
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The author used a questionnaire survey to elicit the views of practice nurses in Lothian on their role. While the sample was small, the results reveal interesting data on the nurses' perceptions of what is most important about work, relationships with patients and GPs, and training needs.