[Miliary cholesterol pneumopathy. Relation to the pulmonary histiocytosis X. (an anatomical observation)].
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Biomedical subjects
Publications and source records attributed to C Brocheriou.
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A diffuse papulo-erosive histiocytosis of the oral mucosa occurred during the fourth year of progression of a case of multiple maxillary eosinophilic granuloma whilst the bone lesions were progressing favourably. This mucosal form appeared to have completed its course in approximately one year, i.e. much more quickly than each of the bony lesions.
A personal case which has been studied has given the authors the opportunity of analysing the characteristics of clear-cell adenocarcinoma of the vagina in a young girl. Adhesions are most often discovered in cases of metrorrhagia or discharge about the time of puberty. Thence as a friable tumour on the anterior wall of the vagina. Usually diethylstilboestrol has been given during intrauterine life. Histologically clear cell carcinomata of the vagina are characterised by a glandular structure in which large cells with large nuclei and clear cytoplasm as well as small cells with "tapestry-maker nail patterns" are found together. Treatment is surgical: total colpohysterectomy with conservation of the ovaries, with lymphadenectomy and with conservation of a vaginal cavity. Prevention consists in screening those who have been exposed to the risk and treating lesions that have been found, but above all in care in using estrogens in pregnant women.
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Over a period of 20 years and among a total amount of 585 tumors of the jaws including 61 sarcomas, 4 benign cartilaginous tumours and 11 chondrosarcomas have been observed. Chondromas and osteo-chondromas, exceptional in this site, occured one time in the median and anterior part of the upper jaw and three times in the coronoid process, the condyle and in the area of the symphysis of mandible. Chondrosarcomas of the jaws, observed in relatively young patients, have a tendency to involve the upper jaw and to recur repeatedly. Moreover they are characterized by an increased severity with regard to osteosarcomas and fibrosarcomas of same location.
Three cases of simple ameloblastoma were studied by electron microscopy. The classical ultrastructural features of these tumors are analysed and compared with reports in the literature and the development of the enamel organ. The authors stress the presence of two cell types (light and dark) probably corresponding to different degrees of maturity. One case of cystic ameloblastoma and one of granular cell ameloblastoma are then reported. The nature of the inclusions in this latter tumour is probably mixed: lysomal and secretory, perhaps ameloblastic. Finally, a malignant ameloblastoma is described under electron microscopy, for the first time. Closely related to simple ameloblastomas, it may be distinguished only by the presence of signs of cellular degeneration and numerous mitoses, sometimes abnormal.
Tissular and cellular radiation-induced injuries. The authors examine morphological, tissular and cellular radiation-induced injuries utilizing anatomo-clinical case reports and experiments in the pig. One must distinguish early and delayed tissular lesions. In the latter, appearing in general after at least six months, vasculo-connective changes are the most important, leading to sclerosis. Indeed, because of the vascular damages the histo-haematic barrier is enlarged leading to a decrease of tissular resistance to injury, long and difficult tissular repairs after a surgical operation. At the end the authors mention some special morphological features concerning the site of lesions.