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Biomedical subjects

C Brocheriou

Publications and source records attributed to C Brocheriou.

At least 19 recordsLinked to original sources
PubMed1992

[Unusual localization of an olfactory esthesioneuroma].

Olfactory neuroblastoma, a nerve tumour arising in the olfactory mucosa, is a relatively easy diagnosis in the case of a mass centered around the cribriform plate. It is more difficult to diagnose in its exceptional ectopic forms (maxillary sinus) in the absence of any cytological and histochemical arguments (fibrils, olfactory rosettes). Its local malignancy is variable with a 42% 5-year survival for stage C and metastases in 30% of cases (principally cervical nodes, bone and liver). The role of imaging is to define the criteria of a mass syndrome and to perform the preoperative staging in a case of apparently simple sinus obstruction.

Brain Neoplasms↗
PubMed1992

[Polymorphous low-grade adenocarcinoma of the minor salivary glands. Seven cases].

Seven cases of polymorphous low-grade adenocarcinoma of the minor salivary glands are reported. This fairly recently described tumor, which is not exceptional, is characterized by a polymorphous architecture, fairly uniform cytologic features, and a marked tendency to infiltrate neighboring structures with perineural spread in virtually every case. Immunohistochemical and ultrastructural studies reported in the literature have demonstrated that the tumor cells exhibit epithelial and myoepithelial differentiation. These tumors probably arise from reserve cells in terminal ducts. The histologic study should eliminate two other tumors that carry a very different prognosis, i.e., pleiomorphic adenoma and the tubular, cribriform variety of cystic adenoid carcinoma. Low-grade polymorphic adenocarcinomas grow slowly. Recurrences are infrequent. Metastases are rare and involve only regional lymph nodes. The morphologic features and course of these tumors explain the term "low-grade polymorphous adenocarcinoma" used to designate them.

Adenocarcinoma↗
PubMed1991

[Epithelial-myoepithelial carcinoma of the salivary glands. Study of 15 cases and review of the literature].

Epithelial-myoepithelial carcinoma initially described by Donath in 1972 represents about 0.5% of salivary gland tumors. Total number of reported cases brings to at least 56 cases; we add 15 personal cases. These 71 cases included 46 women and 25 men. The ages range from 23 to 91 years with peak incidence from the 6th to the 8th decades. The majority of tumors (58) arose in the parotid gland. Of the 71 patients local recurrences occurred in 20, cervical lymph node metastasis in 6 and 2 patients died of their disease. Epithelial-myoepithelial carcinoma typically have a multinodular growth pattern with islands of tumors separated by dense fibrous connective tissue. These tumor masses were composed of well-defined tubules lined by two layers of cells: outer cells are large clear with variable amount of glycogen, inner cells are small, cuboidal and eosinophilic. Perineural invasion and necrosis were occasionally seen. In some cases, this biphasic pattern was less apparent with solid masses of clear cells. Electron microscopic and immunohistochemical studies confirmed the epithelial and myoepithelial differentiation. The differential diagnosis included all clear cells tumors of salivary glands (mucoepidermoid carcinoma, acinic cell carcinoma, sebaceous carcinoma) and also metastatic renal carcinoma. Epithelial-myoepithelial carcinoma is a tumor of low-grade malignancy of duct origin which should be differentiated from salivary duct carcinoma.

Adult↗
PubMed1991

[Leiomyosarcoma of the larynx. Histological, immunohistochemical and ultrastructural study of a case with review of the literature].

Laryngeal leiomyosarcoma: histological, immunohistochemical and ultrastructural study of one case with review of the literature. Leiomyosarcoma of the larynx have rarely been reported and a review of the literature has yielded only 8 cases. Authors report a case in a 45-year-old patient. Histological exam of the surgical specimen showed a malignant spindle cell tumor. Ultrastructurally, neoplastic cells presented some features of smooth-muscle cells. Immunohistochemical studies revealed that most tumor cells coexpressed vimentin and smooth-muscle actin.

Actins↗
PubMed1990

Cystic benign lymphoepithelial lesion of the salivary glands in HIV-positive patients. Report of two cases with immunohistochemical study.

Two cases of cystic benign lymphoepithelial lesions (CBLL) of the submandibular and parotid glands occurring in HIV-positive patients are reported. The clinical and pathological criteria are defined and the differences from Sjögren's syndrome discussed. The presence, in the epithelial component, of T-cells labelled by the human mucosal lymphocyte antibody argues for a primary involvement of epithelial structures in CBLL, the lymphoid hyperplasia occurring secondarily.

Adult↗
PubMed1990

WHO International Histological Classification of Tumours. Tentative Histological Classification of Salivary Gland Tumours.

The principles of the proposed modified WHO Histological Typing of Salivary Gland Tumours are based on the following: 1) The classification of tumours is oriented to the routine work of the practicing surgical pathologists, those who do not see tumours of the salivary glands very often. The inclusion of rare, but clearly defined tumour entities should be helpful to surgical pathologists consulting with clinical specialists. 2) The different types of carcinomas must be distinguished not only by precise histopathological definitions, but also considering differences in prognosis and treatment. For example, the polymorphous low-grade adenocarcinoma and the epithelial-myoepithelial carcinoma are characterized by a relatively good prognosis in contrast to the salivary duct carcinoma. 3) Special points of discussion are: subclassification and grading of carcinomas (e.g. acinic cell carcinoma, mucoepidermoid carcinoma and adenoid cystic carcinoma), the classification of basal cell tumours (basal cell adenoma, basal cell carcinoma, solid type of adenoid cystic carcinoma), malignant tumours in pleomorphic adenomas and the differential diagnosis between primary tumours and metastases.

Adenocarcinoma↗
PubMed1990

[Detection of cancer of the prostate. A study of 600 cases].

A free screening consultation for carcinoma of the prostate was proposed to men over the age of 50 years working in different companies in the areas of Paris. This consultation included a digital rectal examination, a blood test for determination of serum acid phosphatase and prostatic specific antigen, and two dimensional trans-rectal ultrasonography of the prostate. 600 patients were seen. 575 were evaluable. Prostate biopsy was recommended in 152 men. Ninety-three prostate biopsies were performed. Eighteen prostatic cancers and 1 urothelial cancer invading the prostate were detected with an overall incidence of prostate cancer of 3.1%. Radical prostatectomies were performed in 10 of the 18 patients with a prostate cancer. Sensitivity of digital rectal examination ultrasonography and PSA were respectively 42.8%, 47.3% and 68.4% with an abnormal serum PSA level defined as being greater than 5 ng/ml. The predictive value of a positive ultrasonography (18.7%) contrasts with the predictive value of a positive digital rectal examination (30.7%) and serum PSA (30%). Digital rectal examination and determination of serum prostatic specific antigen seem to be the most useful tests for mass screening of prostate cancer. Transrectal ultrasonography is very useful for guided prostatic biopsy and for a better topographic evaluation of the tumor.

Aged↗
PubMed1990

[Carcinosarcoma and spindle cell carcinoma of the bladder. A comparison of 2 cases with an immunohistochemical study].

These two cases of bladder tumours with an unusual histological appearance were observed at Hôpital Saint-Louis in 1988. They contained two cellular components: the usual epithelial type and a spindle cell type. Immunohistochemistry performed in order to identify the various cell contingents established the diagnoses of carcinosarcoma and spindle cell carcinoma and emphasised the differences and similarities between these two entities, which we believe can be differentiated.

Aged↗
PubMed1990

[Neuroendocrine carcinoma of the esophagus].

Small cell neuroendocrine carcinomas are frequent in the bronchial tree, but are very are in the gastrointestinal tract. A 51-year-old woman underwent total esophagectomy for an ulcerated tumor of the lower third of esophagus. Pathologic examination showed an infiltrating small cell carcinoma, and immunohistochemical analysis proved it to be neuroendocrine. The patient died 2 months later from respiratory failure related to pleuritic metastases. Review of the 162 previously published cases showed a mean survival of 6.2 months, and rapid dissemination of metastatic disease, as in our case. As for small cell bronchial carcinoma, systemic chemotherapy should be considered for neuroendocrine carcinoma of the esophagus.

Carcinoma, Small Cell↗
PubMed1990

[Mycotic infection in immunosuppressed patients. An anatomopathologic study].

Mycotic infections are a frequent and often severe complication in the immunosuppressed patient. A review of autopsy findings in 54 cases with gross, histologic and mycologic studies was undertaken among immunocompromised patients after chemotherapy or allogenic bone marrow transplantation: fungal infections were either localized especially in lungs and gastrointestinal tract, or disseminated. Fungi were various: principally Candida and Aspergillus, but also Fusarium, Torulopsis and Trichosporon. In acquired immunodeficiency syndrome (11 autopsy cases), mycotic infections appeared different. Oral and esophageal candidiasis could be found, but cryptococcosis and histoplasmosis were the major generalized mycosis. This study suggests that fungal infections are not the same in patients treated by chemotherapy or bone marrow transplantation, and in acquired immunodeficiency syndrome.

Acquired Immunodeficiency Syndrome↗
PubMed1990

Kikuchi's histiocytic necrotizing lymphadenitis.

Histiocytic necrotizing lymphadenitis (HNL) or Kikuchi's Disease is a peculiar condition most commonly affecting cervical lymph nodes in young women. Histology and immunohistochemistry demonstrate a florid T-cell and histiocytic reaction associated with necrotic areas which must be carefully distinguished from malignant lymphoma. Usually, the disease resolves spontaneously within a few weeks or months. The etiology is unknown and the physiopathology discussed.

Diagnosis, Differential↗
PubMed1990

[Cysts and pseudocysts of the parotid].

Parotid gland are subdivided in malformative dysgenetic cysts and in acquired cysts. Among malformative cysts, lymphoepithelial cysts so-called branchial cysts are the most frequent. Histologically the cystic cavity is lined by squamous epithelium with various amounts of underlying lymphoid tissue. Other varieties of malformative cysts are exceptional: cystic teratomas with several sorts of adult tissues, polycystic parotid gland and congenital ductal ectasia. Acquired cysts are another important group: retention cysts are found in adult and old people. Microscopically these cysts are lined by a single or pseudostratified epithelium rested on a layer of connective tissue without any lymphoid tissue. Lymphoid cystic hyperplasia arising in HIV infection can be included in this group of acquired cysts. Finally these parotid cysts have to be differentiated from pseudocysts without an epithelial lining and from cystic tumors as cystadenolymphoma and cystic mucoepidermoid carcinoma.

Cysts↗
PubMed1990

[Myxoma of the nerve sheath. Apropos of a case].

A case of oral nerve sheath myxoma is presented with the findings of light microscopy and immunochemistry. The tumor consists of well-defined lobules which are separated by septa composed of fibrous connective tissue that reassembled the perineurium. Each lobule is composed of elongated and stellate cells in a basophilic mucoid matrix. Immunohistochemically, S-100 protein is strongly positive in all tumor cells. The histogenesis and differential diagnosis are discussed.

Adult↗
PubMed1990

[Hyalinizing trabecular adenoma of the thyroid gland. Histologic and immunohistochemical study. Report of 2 cases].

Hyalinizing trabecular adenoma of the thyroid gland is an uncommon neoplasm that was recently described by Carney et al. (1987). It is important to recognize this tumor, considered benign, as it may mimic papillary carcinoma, medullary carcinoma or paraganglioma. We present two cases with histological and immunohistochemical criteria and discuss the diagnostic problems. Grossly, this small tumor is yellow tan and well circumscribed. The epithelial cells, polygonal or elongated and sharply outlined, have an eosinophilic or clear cytoplasm. The nuclei are oval or elongated, with often non-visible nucleoli. Grooved nuclei are quite frequent. Mitotic figures are very uncommon. The cells are arranged in clusters or trabeculae or pseudofollicles containing colloid material. Characteristically the cells, arranged shoulder to shoulder, can show a palisade pattern. The fibrovascular stroma appears hyaline, pseudoamyloid (Congo red staining is negative). The tumor cells show intense staining for thyroglobulin and no staining for thyrocalcitonin. Immunoreactivity for cytokeratin, vimentin, protein S100, NSE is positive but staining is negative for EMA and desmin. In one case, the tumor cells show little positivity for chromogranin A. The variable patterns of this tumor can lead to diagnostic problems. We can exclude the diagnosis of papillary carcinoma as this tumor lacks any true papillary architecture. We reject the diagnosis of medullary carcinoma because of its thyroglobulin and calcitonin immunoreactivity. Paraganglioma never shows immunoreactivity for thyroglobulin. Very often the surrounding thyroid tissue shows focal thyroiditis. The association of the tumor with Hashimoto's thyroiditis can be explained by an autoimmune process.

Adenoma↗
PubMed1990

[Idiopathic calcinosis of the scrotum. Apropos of 2 cases].

The authors report two cases of idiopathic calcinosis of the scrotum studied between the years 1986-1987 at the Central Histology Laboratory of Hopital St-Louis. These patients had subcutaneous calcinosis strictly limited to the scrotum and not accompanied by any clinical signs or abnormal laboratory parameters. The macroscopic and histological appearance of the lesions is typical and should suggest the diagnosis. Numerous authors have tried to attribute a pathogenic interpretation to this lesion, but the various etiologies proposed are still purely hypothetical.

Adult↗
PubMed1989

[Idiopathic calcinosis of the scrotum. Apropos of 2 cases].

The authors report two cases of idiopathic calcinosis of the scrotum studied between the years 1986-1987 at the Central Histology Laboratory of Hopital St-Louis. These cases presented subcutaneous calcinosis strictly limited to the scrotum and not accompanied by any clinical signs and no abnormal laboratory parameters. The macroscopic and histological appearance of the lesions is typical and should suggest the diagnosis. Numerous authors have tried to attribute a pathogenic interpretation to this lesion, but the various etiologies proposed are still purely hypothetical.

Adult↗