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Biomedical subjects

C Brenner

Publications and source records attributed to C Brenner.

At least 109 records · Page 6Linked to original sources
PubMed1988

CDC33 encodes mRNA cap-binding protein eIF-4E of Saccharomyces cerevisiae.

The bcy1 mutation makes the cdc33 start mutant arrest at random points in the cell cycle instead of only at G1. We cloned and sequenced CDC33. This coding sequence is identical to that of the gene encoding the Saccharomyces cerevisiae 24-kilodalton mRNA cap-binding protein, eIF-4E.

Amino Acid Sequence↗
PubMed1987

GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction.

GPA1 protein of Saccharomyces cerevisiae is homologous to the alpha subunit of mammalian G protein. GPA1 transcript was found in haploid cells but was not detected in diploid cells. Disruption of GPA1 resulted in a haploid-specific lethal phenotype, indicating that GPA1 is a haploid-specific essential gene for cell growth. Upon regulation of expression of GPA1 by the galactose-inducible GAL1 promoter, the loss of GPA1 function was found to lead to cell-cycle arrest at the late G1 phase. Mutants that suppress the lethality of the gpa1::HIS3 mutation showed a sterile phenotype that was not cell-type-specific. These results suggest that GPA1 protein may control the signal for mating-factor-mediated cell-cycle arrest.

Cell Cycle↗
PubMed1987

Notes on psychoanalysis by a participant observer: a personal chronicle.

Experience has shown how difficult it may be to decide which ideas are of passing interest and relatively little value and which are more important and fruitful. Examples of each are given in the form of a personal memoir. Some thoughts are added about the present and the future from the same vantage point.

Ego↗
PubMed1987

Working through: 1914-1984.

This paper reviews the various meanings given to "working through" by Freud and others. The relation of "working through" to "analysis" is discussed and illustrated.

Austria↗
PubMed1985

Countertransference as compromise formation.

Countertransference is a ubiquitous phenomenon, a set of compromise formations comprising the analyst's transference to the patient(s). Some consequences of this fact are discussed, including the factors responsible for those instances when countertransference impedes analysis.

Countertransference↗
PubMed1982

The concept of the superego: a reformulation.

1. The superego is a group of compromise formations, all having to do with morality, which originate, in large part, in the oedipal phase of development. 2. Once formed as a consequence of conflict, the superego functions as a major component of (subsequent) conflicts. 3. Its role in conflict is diverse. It functions now as defense, now as the equivalent of a drive derivative arousing unpleasure, and now as a calamitous unpleasure to be avoided or mitigated. 4. For a young child "moral" equals approved by parents, while "immoral" equals the reverse. The crucial moral questions at the time of life when the superego is largely formed are, "What will win or forfeit parental approval?" and "What will rouse or dissipate parental wrath?" 5. From the side of ego functioning, superego formation involves much more than identification with parental superego demands and prohibitions. Any aspect of ego functioning which furthers parental approval and/or avoids disapproval and punishment can and does participate in superego formation. 6. From the side of the drives, both libido and aggression are involved in superego formation. Hence masochism plays a role in normal superego formation and functioning as well as in those pathological cases which Freud called moral masochism. 7. Superego pathology is not to be understood, as it has been generally understood by analysts until now, in terms of defective or incomplete development. Everyone has a fully formed superego. Superego pathology must be understood on the same basis as is the pathology of any compromise formation.

Aggression↗
PubMed1980

Metapsychology and psychoanalytic theory.

Various meanings have been given to the word "metapsychology" by its opponents and proponents in the psychoanalytic literature. These are discussed and compared with the meaning Freud intended the word to have. The question of the place of psychoanalytic psychology in science--whether it is or is not in natural science--is also considered.

Consciousness↗
PubMed1979

Working alliance, therapeutic alliance, and transference.

Examination of the clinical evidence offered by proponents for the concepts of therapeutic and working alliance leads the author to conclude that neither concept is justifiable. Both refer to aspects of the transference that neither deserve a special name nor require special treatment. The related topic of frustration/gratification as necessarily inherent in the analytic situation is also considered.

Awareness↗
PubMed1979

Depressive affect, anxiety, and psychic conflict in the phallic-oedipal phase.

The author's recent contributions to affect theory and its relation to psychic conflict are applied to the understanding of the nature, genesis, and consequences of psychic conflict in the phallic-oedipal phase. These contributions lead to a better understanding of 1) the importance of depressive affect in phallic-oedipal conflicts, 2) similarities and differences between such conflicts in boys and girls, 3) depression as a symptom in adult life, and 4) some aspects of narcissism.

Anxiety↗
PubMed1977

[Systolic and diastolic left ventricular function in hypertrophic obstructive cardiomyopathy].

Systolic and diastolic left ventricular and myocardial performance were analysed in ten patients with hypertrophic obstructive cardiomyopathy (HOCM) from biplane cineangiograms and simultaneous pressure recordings. In spite of significant geometrical abnormalities, pump function of the left ventricle on the average was normal. Only in two cases ejection fraction and isovolumic phase indices, respectively, were moderately reduced. On the contrary nine of ten patients had a considerable reduction of left ventricular distensibility, partly due to a decreased myocardial compliance. The symptoms of patients with HOCM cannot be explained by an impaired systolic pump function, they are primarily caused by a disturbed ventricular und myocardial function during diastole.

Adult↗