Search PubMed⌕ Search

Biomedical subjects

C Brancati

Publications and source records attributed to C Brancati.

61 records · Page 4Linked to original sources
PubMedDate not supplied

Glucose-6-phosphate dehydrogenase (G6PD) deficiency in the Albanian ethnic minority of Cosenza province, Italy.

The Albanian ethnic minority of the Cosenza province (Calabria, Southern Italy) is constituted by a population of 42,305 inhabitants living in 19 communes. The first presence of this population, in Southern Italy, dates back to the fifteenth century as a result of different immigrations. We have studied the G6PD in the population of this province by determining both the frequency of the G6PD-deficiency and the type of Gd(-) alleles in samples from 19 communes. The overall frequency estimate turned out to be 0.0294 and those of the 8 highland communes and of the 11 communes located in the valleys were 0.0242 and 0.033 respectively. Both the frequencies and the ratio between the frequencies of the different Gd(-) alleles are significantly different with respect to a previous study carried out on the non-Albanian population of the same areas. The high endogamy rate found among the grandparents' and among the parents of the probands living in the Albanian community, shows that this community is to a large extent reproductively isolated from the neighbouring populations, thus accounting for these differences.

Adolescent↗
PubMedDate not supplied

XbaI-RFLP of the APOB gene in a sample group from southern Italy.

The XbaI Restriction Fragment Length Polymorphism (RFLP) of the APOB gene at codon 2488 was investigated in a sample group from Southern Italy (165 subjects), taken from a population characterized by a low average level of cholesterolemia. The X2 allele (presence of XbaI cutting site), that in several groups was found to be associated with increased cholesterolemia, showed in Southern Italians a frequency of 39% which is significantly (P much less than 0.001) lower than that found in the majority of the Caucasoid groups so far tested (50%). However, an analysis of both cholesterol and APOB serum levels performed in a sample of 82 subjects, homogeneous for sex and age did not reveal any significant association between lipidemic parameters and APOB-XbaI genotypes.

Alleles↗
PubMedDate not supplied

Osteoporosis in patients affected with thalassemia. Our experience.

The authors examine 72 patients affected with homozygous B-thalassemia; The study was conducted by clinical-hematological and radiologic examination. The Singh method is used to compare clinical data with the degree of osteoporosis. The results indicate that there is a high frequency of osteoporotic abnormalities in thalassemia. The authors postulate that osteoporotic lesions are principally caused by hyperplasia of the marrow, the overactive bone marrow widening the medullary space and the increased intramedullary pressure causing osteoporosis.

Adolescent↗
PubMedDate not supplied

Genetic polymorphism at the phosphoglucomutase 1 (PGM1) locus in Cosenza Province (Calabria--southern Italy).

1315 school-boys of the Cosenza province (Calabria - southern Italy) were subtyped for the PGM1 locus. Three subsamples were examined, two from the Tyrrhenian and the Ionian coasts, respectively, and one from the internal part of this province. The PGM1*1S, PGM1*2S and PGM1*2F gene frequency estimates obtained for the population of the Ionian coast were significantly different from those of the tyrrhenian coast. Since the three subsamples were of similar size, estimates weighted also with the respective population sizes were calculated.

Adolescent↗
PubMedDate not supplied

IGHG1 phenotypes in three population samples from Italy (Albanians, Calabrians, northern Italians): a critical revision.

This paper presents data on the distribution of IGHG1 phenotypes in three populations living in Italy (Albanians, Calabrians and Northern Italians). IGHG1 typing for the allotypes z, x, a, f has been performed by using standard antisera provided by the Central Laboratory of the Netherlands Red Cross Blood Transfusion Service (Amsterdam). The results are compared with those obtained for the same populations using alloantisera from polytransfused subjects and Behringwerke antisera. It is shown that the results obtained by using the different antisera are not in agreement. Moreover, standard antisera reveal that the IGHG1 za haplotype is more frequent in Albanians than in Northern Italians.

Adolescent↗