Biomedical subjects

C Boutteville

Publications and source records attributed to C Boutteville.

21 records · Page 2Linked to original sources

PubMed1985

[Prevention of peritoneal adhesions by local treatments. Experimental study in the rat].

Those local treatments that are most used clinically for the prevention of adhesions in the pelvis have been evaluated experimentally using peritoneal abrasion in the rat. In a first experiment these products, namely dexamethasone, high molecular weight dextran, and noxytioline, were compared with a saline solution on the one hand which confirmed the effect of these substances in preventing adhesions, and on the other hand showed that noxytioline was about as effective as dextran 70 and better than corticosteroids. The score for adhesions that were found were; in the control series an average of 9.25, in the dexamethasone series 6, in the dextran 70 series 4.1 and in the noxytioline series 4.00. This last substance, which has been for less broadly studied than dextran, was then made the subject of a second experiment carried out in the same way as the first, and showing that the anti-adhesion effect was not something that was added on to its anti-bacterial effect because noxytioline alone was more effective than a broad spectrum antibiotic by itself, and adding the two together gave a still better result. It would seem to us that using noxytioline and dextran 70 together does not improve the results achieved by using each substance by itself.

Animals↗

PubMed1984

[Diagnostic evaluation of fetal distress during pregnancy by a sound stimulation test].

A vibro-acoustic stimulus induces in the human fetus over 28 weeks of gestational age some modifications of the fetal heart rate. Absence of response, as a single test, has been used to suggest the diagnosis of fetal jeopardy (Read and Miller, Trudinger and Boylan). In this series, the pronostic value of the sound stimulation test (SST) was evaluated in association with the results of the widely used non stress test (NST). In 78 patients, 93 pathological NST, quantified by means of the Fischer's score, were assessed by SST. The results showed a good correlation between NST and SST : SST appears to be negative (no fetal response) in respectively 10%, 48% and 100% of NST tracings with Fischer score of 7, 6 or less than or equal to 5. Thus, when the basal Fischer score indicates fetal distress, no complementary test is needed (all 11 infants showed low Apgar score or acidosis). On the other hand, when the NST is less severely abnormal (score 6 or 7), the SST allows a good discrimination of the risk of neonatal distress. Among 62 cases explored less than one week before birth, a 27% (17/62) overall probability of neonatal depression (low Apgar score at 5 minutes and/or acidosis in the umbilical artery at birth) was noticed. The SST was interpreted as reactive in 44 cases of this group, with only 8 depressed neonates (18.2%). In the other 18 cases, a negative SST was followed by birth of 9 depressed infants (50%). The difference is statistically significant (p less than 0.02).(ABSTRACT TRUNCATED AT 250 WORDS)

Acoustic Stimulation↗

PubMedDate not supplied

Prognostic value of suppressed thyrotropin level and positive thyrotropin-receptor antibody activity in Graves' disease with long-lasting clinical remission.

OBJECTIVE: To determine the prognostic value of suppressed thyrotropin (TSH) level and positive TSH-receptor antibodies (TSH-R Ab) in patients with Graves' disease who have long-lasting clinical remission. METHODS: We retrospectively studied patients with Graves' disease who underwent follow-up for a mean of 55 months after the withdrawal of antithyroid drug treatment. Study patients were 84 consecutive subjects in clinical remission, with normal serum free thyroxine (FT(4)) and free triiodothyronine (FT(3)) levels, regardless of serum TSH levels, a mean of 35 months (range, 6 to 135) after discontinuation of carbimazole therapy. Eighty-seven euthyroid subjects were used as control study participants. All subjects had serum determinations of FT(4) and FT(3) (radioimmunoassay), TSH (highly sensitive immunoradiometric method), TSH-R Ab (radioreceptor assay), and microsomal antibodies (M Ab, passive hemagglutination method). RESULTS: In the study patients, serum TSH was suppressed (</=0.10 mU/L) in 13 cases (15%), TSH-R Ab were positive (>/=15%) in 11 cases (13%), and M Ab were positive (>/=1:100) in 54 cases (64%). Simultaneous suppressed TSH and positive TSH-R Ab levels were present in six patients. During the follow-up, 11 patients had a relapse, demonstrated by above-normal values for serum FT(4) and FT(3) in association with clinical symptoms of hyperthyroidism. Five of them had a previously suppressed TSH level, three had a positive TSH-R Ab level, and six had a positive M Ab titer. Relapse was significantly more likely in patients with a previously suppressed TSH level (P<0.02) but not in patients with a previously positive TSH-R Ab level or positive M Ab titer. CONCLUSION: Patients with Graves' disease and long-lasting clinical remission after discontinuation of carbimazole therapy may have a suppressed TSH level, a positive TSH-R Ab level, or a positive M Ab titer (or some combination of these findings). Although positive TSH-R Ab and M Ab have no significant prognostic value, a suppressed TSH level is indicative of subclinical hyperthyroidism and higher risk of relapse.

Journal Article↗