Search PubMed⌕ Search

Biomedical subjects

C Boutin

Publications and source records attributed to C Boutin.

At least 145 records · Page 8Linked to original sources
PubMed1990

[Endobronchial tuberculosis simulating cancer].

Endobronchial tuberculosis may simulate a bronchial neoplasm. It is the data from a bronchial biopsy carried out along with the X-ray and endoscopy examination followed by the bacteriology of the expectorating sputum which enables a diagnosis to be made. This form of diagnosis is known but is rare. The clinical outcome is very good after specific treatment, although the radiological signs and above all the endoscopic findings improve more slowly.

Adult↗
PubMed1990

[The value of initial thoracoscopy in the treatment of pneumothorax].

Various methods have so far been used to treat pneumothorax, including rest, needle exsufflation and blind drainage. The results obtained are varied but the recurrence rate is high, averaging 50%. With thoracoscopy, not only can the pleura be explored and the cause of pneumothorax investigated, but specific treatment of the lesions can be carried out in some cases and symphysis can be obtained by pleural poudrage, thereby avoiding recurrences. One-hundred and eleven cases of pneumothorax collected over a 5-year period are reviewed in this study; the results of exploration and those of endoscopic treatments are given and commented upon.

Adolescent↗
PubMed1989

[Experimental study of the pleural effects of the pulverization, under thoracoscopic control, of a fibrin glue (Tissucol)].

The instillation of a fibrin sealant (Tissucol) has been proposed in the treatment of recurrent spontaneous pneumothorax. The present work is devoted to an experimental study in the dog of the effects of this substance on the pleural cavity one and two weeks after instillation under thoracoscopic control. Its action is compared to that of placebo (methylene blue). The instillation of a placebo (n = 5) did not alter the ventilatory mechanics or the structure of the pleura. On the other hand Tissucol (n = 6) led to a fall in the thoraco-pulmonary compliance (-14%), corresponding to that of the vital capacity (-10%). In these animals, no pleural symphysis was noted, but the histological analysis gave evidence of changes in the layers of the parietal and visceral pleura: an inflammatory mononuclear reaction (71% of cases) and/or polymorphonuclear (54%), recent fibrosis (67%) and more rarely a mesothelial hyperplasia (21%). The maintenance of the integrity of the mesothelial cellular layer would explain the absence of pleural symphysis after instillation of Tissucol. These results as well as those recently obtained in the human situation prompt us to advise other methods of pleural symphysis which have been tried and tested, such as talcage or surgery.

Animals↗
PubMed1989

[Complicated hydatid cyst of the lung. Endoscopic diagnosis. Spontaneous favourable outcome].

We report the case of a 16-year old male patient admitted for bronchial suppuration, haemoptysis and opacity with abscess located in the inferior lobe. General deterioration, notably a loss of 10 kg in 2 months, and the radiological findings were strongly suggestive of tuberculosis, pyogenic abscess or malignant process. Bronchial fibroscopy provided a diagnosis of hydatid cyst by showing shreds of the cyst membrane protruding through the opening of the posterior basal segmental bronchus. The diagnosis was confirmed by pathological examination and serological tests. The spontaneous course of the disease was favourable, with complete emptying of the cyst contents following vomica. The need for surgery is discussed.

Adolescent↗
PubMed1989

Thoracoscopy in malignant mesothelioma.

Thoracoscopy is a suitable diagnostic method in malignant mesothelioma, since it enables simultaneously histopathological diagnosis, identification of asbestos fibres, staging of tumour spread, and pleurodesis therapy.

Biopsy↗
PubMed1989

The laser in thoracoscopy.

The various possibilities of laser application in thoracoscopy are explained, such as closure of defects after lung biopsy or in pneumothorax, cauterisation of emphysematous bullae, etc.

Biopsy↗
PubMed1987

Serum hyaluronate in malignant pleural mesothelioma.

The diagnostic value of hyaluronate concentration in effusions of malignant mesothelioma has been extensively reported but no information is available about serum hyaluronate in patients with this cancer. Using a new enzymoimmunologic assay based on hyaluronate-hyaluronectin interaction, serum levels of hyaluronate were measured in 16 patients with malignant pleural mesothelioma, 50 patients with other pleural effusions, and 94 healthy blood donors. The mean serum hyaluronate level in patients with mesothelioma (mean, 750 micrograms/l; range, 29 to 5833 micrograms/l) was significantly higher than in patients with other pleural effusions (mean, 56 micrograms/l; range, 4 to 137 micrograms/l) and than in blood donors (mean, 24 micrograms/l; range, 0 to 94 micrograms/l). Comparison of serum hyaluronate values observed in mesotheliomas with the clinical course of the disease suggests that serum hyaluronate might increase only at an advanced stage of the cancer. Therefore, serum hyaluronate determination has probably no clinical value for early detection of malignant mesothelioma, but might be useful to evaluate the clinical course of this malignancy.

Adult↗
PubMed1987

[Pleural plaques and an asbestos environment in Northern Corsica].

As opposed to North-West Corsica, North-East Corsica is rich in asbestos outcrops and a source of environmental pollution as can be seen in the airborne concentration of chrysotile and above all tremolite. We have composed the frequency of asbestos pleural plaques occurring in subjects in the two regions starting with a retrospective analysis of the radiological records of 1,721 patients born in Northern Corsica and having no occupational exposure to asbestos. The frequency is 3.8% in the North-East and 1.1% in the North-West (p less than 5%). The relative East-West risk, which is 3.3%, shows the existence of a link between pleural plaques and environmental exposure to asbestos in North-East Corsica.

Aged↗
PubMed1987

[Contribution of pulmonary gallium scintigraphy to the diagnosis of pulmonary tuberculosis].

Radioisotope scanning of the lungs with gallium 67 was performed in 13 patients whose radiological images were suggestive of pulmonary tuberculosis. The purpose of the study was to assess the value of that method as a complement to bacteriology in active pulmonary tuberculosis. Provided the lung tissue is not totally destroyed, gallium 67 is strongly taken up by the tuberculous lesions. However, scanning cannot be regarded as a routine examination, as it is costly and delivers a non-negligible dose of radiations. All it can do is to serve as a guide for more invasive investigations.

Adult↗
PubMed1986

[Thoracoscopy of pleural effusions: methods, indications, results].

Thoracoscopy, which was formerly used in active tuberculosis to divide pleuro-pulmonary adhesions and to complete therapeutic pneumothorax, has now become the object of renewed interest. By introducing, after pneumosera and usually into the 4th to 8th intercostal space in the axillary line, a fine trocar into the chest, the whole thoracic cavity, including parietal pleura, diaphragm, lung and fissures, mediastinum and pericardium, can be explored. This technique, performed under local rather than general anaesthesia or under neuroleptanalgesia, is innocuous, inexpensive and effective. In addition, the patient is immobilized for only 4 or 5 days on average and the technique is much less taxing than surgery, which can be avoided in many cases. Thoracoscopy nowadays is mainly used to determine the cause of chronic pleurisy unexplained after 3-4 weeks (positive pleural biopsies are obtained in 92-97% of cancerous or tuberculous patients). Thoracoscopy is half-way between purely medical practice and surgery and deserves to be widely used again by pneumologists, provided they learn to master the technique by regular, assiduous and adequate use.

Humans↗
PubMed1986

[Study of 2 markers, keratin and neuron-specific enolase, in bronchial cancers].

In an immunohistochemical study 31 patients with bronchial cancer (squamous cell 9, large cell 4, small intermediate cell 11 and oat cell 7) were investigated for keratin and NSE. Keratin seems to be a valuable marker since only oat cell cancers and 45% of small intermediate cell cancers were negative. In contrast, marking with NSE seems to be non-discriminating. The low value of NSE as marker was confirmed by 133 serum NSE assays performed in 39 bronchial cancer patients. Although NSE values were significantly higher in oat cell cancer, in any given patient serum assays can, at best, detect relapses.

Bronchial Neoplasms↗
PubMed1986

[Thoracoscopic talc poudrage in pleurisies of blood diseases].

A total of 20 patients aged 50.5 +/- 4.5 years with 24 chronic pleural effusions associated with lymphomas underwent 24 thoracoscopic talc poudrages. Effusions were serofibrinous (32%), hemorrhagic (41%), or chylous (27%). The mean volume of pleural liquid evacuated by repeated thoracenteses before thoracoscopy was 5.2 +/- 0.6 l. Thoracoscopic biopsies confirmed a lymphomatous infiltration of the pleura in 95.5% of cases. A definitive pleural symphysis was obtained in all cases but 2 (92% positive results): in 1 case, a further single thoracentesis of 400 ml was necessary, and in the 2nd case the patient died within 6 days from an acute evolution of her Hodgkin's disease. The mean drainage time was 4.8 +/- 0.2 days. Overall results are thus identical to those obtained in solid tumor-related pleural effusions (91% positive results).

Adolescent↗