Biomedical subjects
C Bourdon
Publications and source records attributed to C Bourdon.
Breast cancer screening programmes--results of studies in foreign countries--situation in Belgium.
Results of randomized trials and case-control studies on breast cancer screening are reviewed. A combined analysis of data from the randomized studies indicates that a mortality reduction (29%) can be achieved by mammographic screening in women. Regular breast cancer screening by mammography for women aged 50-69 years reduces breast cancer mortality by 40% (confidence interval [CI] 95% about 27-55) in women who are screened at least once. In younger women, the results are inconclusive. The programme Europe against Cancer has recommended the setting-up of a network of pilot studies on breast cancer screening by mammography in the European Community in order to obtain the necessary experience, with a view to implementation of a national screening programme before the year 2000. In the Brussels project, the main objective is to develop a programme of quality assurance. In Belgium, there are other projects with different designs, for which the results are not yet available.
Epidemiological survey of preinvasive breast cancer.
DCIS and LCIS are different breast diseases at various points of view. DCIS has in most cases a clinical or mammographical pattern, whereas LCIS represents an incidental finding in breast tissue removed for another reason. However, DCIS found incidental to benign disease may be a more innocuous form of tumour. Multifocal foci are more frequent in LCIS than in DCIS, but microinvasion and coexisting unsuspected infiltration carcinoma are more often found in DCIS. Contralateral in situ breast carcinoma is a rare event in DCIS. It is seldom found in LCIS. The risk of development of an infiltrating ipsilateral carcinoma after biopsy or excision showing in situ carcinoma is higher for DCIS than for LCIS. However, in most cases the invasive tumour occurs at or near the site of the original biopsy. Among LCIS patients, invasive carcinoma occurs anywhere in the breast parenchyma. The risk of development of contralateral invasive cancer is very low in DCIS patients, but it is high in LCIS patients. It may be lobular, ductal or a mixture of different types. DCIS has to be considered as a truly preinvasive lesion although LCIS is rather a marker of increased risk.
[Systematic mammographic screening for breast cancer in asymptomatic women].
It appears that the mortality rate from breast cancer decreases in 50-year-old (and over) women submitted to mammographic screening. Since 1980, the Unit of Cancer Prevention of the UCL is proposing mammographic screening to women with normal clinical examination but belonging to a "high-risk" group. Among the 5651 mammographies which were performed on 2924 women, 24 biopsies have been proposed and 16 cases of cancer have been diagnosed. 5.5% breast cancers have been detected. This result is consistent with the average figures reported in the screening programmes abroad. Questions about the age at which cancer screening should start and about the number of views that should be taken are also discussed.
[Conservative attitude in surgery of the temporomandibular joint. Indications and technics].
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[Review of the functional surgical pathology of the temporomandibular joint].
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[Cervicofacial tumors: apropos 6 cases].
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[Mycoplasma pneumoniae infection. Manifestation in a 3-year-old child by Raynaud's phenomenon].
The authors report the case of a 3 year-old boy with mycoplasma pneumoniae infection. The presenting sign was Raynaud's phenomenon with cryoglobulinemia and cryofibrinogenemia. To their knowledge this is the first reported case presenting with such an association.
[Tumors of the accessory salivary glands].
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[Use of latissimus dorsi myocutaneous flaps in head and neck surgery].
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[Early treatment of the nasal component in labiomaxillopalatine clefts].
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[[Evaluation of various methods of studying fecal occult blood].
Occult blood testing for detection of asymptomatic colorectal cancer is an old concept. The authors review the literature about the screening value of current tests. Among the chemical tests, Hemoccult is the most popular and the best studied. Sensitivity and specificity are moderate. False negative reactions are due either to the test itself (high level of sensitivity, loss of reactivity) or to the tumour (intermittent or insufficient bleeding, localization etc...). False positive reactions are due to the interference of a high peroxidase diet. The Hemoccult test is nevertheless interesting because it is simple, cheap and well accepted. Detected cancers tend to be at a relatively early stage: 60 to 80% of Dukes A or B. New methods--Hemoquant and immunochemical methods--are being developed. Their high degree of sensitivity and specificity for human hemoglobin makes them too complex and too costly. Whatever the efficacity of a test to detect occult blood may be, we must know whether the screening of an asymptomatic population could decrease the mortality rate of colorectal cancer, before using it on a large scale. Only long-term controlled trials can give us an answer in the future.