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Biomedical subjects

C Bosman

Publications and source records attributed to C Bosman.

At least 109 records · Page 6Linked to original sources
PubMed1984

Hypereosinophilic syndrome and plasmocytoma. Report of a case and review of the literature.

The 4th case of plasma cell neoplasm associated with a hypereosinophilic syndrome is described and compared with the previous reports. Hypereosinophilia in the present patient displayed some borderline traits with eosinophilic leukemia. Myeloproliferative disorders of the eosinophilic line often present as a precancerous state, but sometimes they seem to acquire malignant independence. In our patient the occurrence of a plasmocytoma with a dramatic course leads to suspect an underlying complex genetic aberration.

Eosinophilia↗
PubMed1982

Criss-cross heart with discordant atrioventricular connections.

A case of criss-cross heart is presented in which there was situs solitus with atrioventricular (AV) discordance and single outlet, the aorta arising from the right ventricle. Associated lesions were pulmonary atresia and ventricular septal defect. The apparently normal AV relation in the presence of a discordant AV connection can be explained by the hypothesis that an embryonic l-bulboventricular loop developed and was followed by marked counter-clockwise rotation of the ventricles.

Electrocardiography↗
PubMed1980

Biometric analysis of splanchnic and somatic weight in infancy.

During 712 consecutive autopsies on liveborn infants, body weight and the weight of single organs were systematically recorded. These data have provided the material for a statistical investigation. Tables and graphs have been prepared to allow a statistical estimate of the normal value of the weight of organs in the first year of life, as a function of body weight and/or the subject's age. It has been shown that in this period, the weight of an organ varies as a linear function of these two independent variables, whose action is sometimes synergic and, more rarely, in conflict in determing the weight of the organ.

Age Factors↗
PubMed1980

Histiocytoid cardiomyopathy in infancy: a new hypothesis?

A case of histiocytoid cardiomyopathy in a ten-month-old boy is reported. Histologic and ultrastructural examinations led us to consider the possibility that the disease, rather than being a focal lesion of the common myocardium as it was heretofore considered, might be regarded as a diffuse lesion on the specific myocardium.

Cardiomyopathies↗
PubMed1979

Ultrastructure and function of the labial nephridia and the rectum of Orchesella cincta (L.) (Collembola).

The collembolan Orchesella cincta possesses a well-developed coelomoduct kidney. The presence of podocytes in the wall of the sacculus and the fact that the epithelium of the nephridial tubule has the ultrastructural characteristics of resorbing cells, indicate that this is an "ultrafiltration-reabsorption" kidney. Apparently also the rectum is lined by a reabsorptive epithelium; the cells possess an extensive system of apical and basal infoldings. This view is sustained by the fact that the stereology of the apical channel system varies in animals kept under different moisture conditions. During the intermoult period, both organs are subject to strong morphological changes, which are obviously related to the feeding rhythm.

Animals↗
PubMed1977

Ultrastructural aspects of chondrodystrophia calcificans congenita (syndrome of Conradi-Hünermann).

An ultrastructural study of chondrodystrophia calcificans congenita is reported. Foci of initial calcification of cartilage are characterized by coexistence of three different types of crystals, probably due to abnormal proteoglycan composition of cartilage matrix. The calcification process in chondrodystrophia calcificans congenita is apparently not related to 'matrix vesicles' as it is in normal cartilage.

Calcinosis↗
PubMed1975

Detection of nerve growth factor binding sites on neuroblastoma cells by rosette formation.

A cloned suspension culture of mouse C1300 neuroblastoma cells bound, at 2degrees, sheep erythrocytes passively coated with nerve growth factor, with the formation of rosettes. When grown in tissue culture dishes to which they could attach, neuroblastoma cells rapidly transformed, within 48 hr emitting cytoplasmic processes some of which were several mm long. Most of the attached neuroblastoma cells formed rosettes. In contrast, normal mouse kidney cells or various murine tumor cell lines used as cell controls exhibited a poor capacity for binding nerve growth factor. Rosette formation was a specific reaction that could be prevented by pretreating cells with proteolytic enzymes, free nerve growth factor, or specific antibodies against neuroblastoma cell extracts.

Animals↗
PubMed1975

Phagocytosis of nerve growth factor-coated erythrocytes in neuroblastoma rosette-forming cells.

At 2 degrees, murine C1300 neuroblastoma cells bound NGF-coated sheep erythrocytes and formed rosettes. When the temperature was raised to 37 degrees, the neuroblastoma cells underwent a rapid transformation characterized by microtubule formation, which occurred under the membrane surface close to the points of contact with the attached red cells. Cytoplasmic processes filled wit- microtubules were then emitted by the cell body and surrounded the red cells. Within 20 to 30 min, the attached erythrocytes were phagocytized. Interiorization of membrane-bound erythrocytes-antibody-complement complexes by neuroblasto-a cells could be similarly induced at 37 degrees. In both cases, the extent of phagocytosis was decreased when microtubule formation was blocked with colchicine or vinblastine. Complete inhibition was obtained only by pretreatment of cells with cytochalasin B, a strong inhibitor of microfilament contraction. The role played by the microtubules and the microfilaments in promoting the phagocytosis of the attached erythrocytes is discussed.

Animals↗