Search PubMed⌕ Search

Biomedical subjects

C Bona

Publications and source records attributed to C Bona.

At least 181 records · Page 10Linked to original sources

In vitro attachment of radioactive endotoxins to lysosomes.

The experiments reported here demonstrate that under certain conditions endotoxin can interact with lysosomes in vitro. After incubation of large granular fraction with (51)Cr-labeled antigen under the conditions required for acid hydrolytic activity, radioactivity was associated with the pellet after centrifugation. This effect can be inhibited by preincubation of the large granular fraction with unlabeled homologous or heterologous endotoxins. High resolution autoradiography showed that (14)C-labeled endotoxin was predominantly attached to the lysosomes contained in the large granular fraction. The mechanism of this interaction and its relationship to the toxic effect of endotoxins on lysosomes are discussed.

Animals↗