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Biomedical subjects

C Blum

Publications and source records attributed to C Blum.

At least 55 records · Page 3Linked to original sources
PubMed1985

Radioactive iodine treatment of metastatic thyroid carcinoma with clinical thyrotoxicosis.

We present a case of well-differentiated follicular carcinoma of the thyroid with hyperfunctioning metastases and clinical thyrotoxicosis. The recommended I-131 treatment dose for patients with widespread bone metastases from thyroid carcinoma is 200 mCi. However, in a patient with hyperfunctioning metastatic tumor and increased radioiodine uptake, the treatment dose should be modified. Radiation dosimetry measurements performed on the patient in this study demonstrated that 132 mCi would be a safe therapeutic I-131 dose which would avoid injury to normal radiosensitive tissues. Consequently, she was given a 130-mCi therapeutic dose.

Adenocarcinoma↗
PubMed1985

[Not Available].

Explore the source record for details and available documents.

Death↗
PubMed1983

Inferential processing of context: studies of cognitively impaired subjects.

Language comprehension tasks involving pronoun coreference were administered to a group of demented patients, a group of patients with cardiac disease, and groups of normal elderly persons and young adults. Pronoun coreference was constrained by either lexical, syntactic, or contextual cues. No differences were found between old and young subjects for any task. While the demented patients were impaired on all tasks, the cardiac patients were specifically impaired in the inferential processing of context.

Adult↗
PubMed1982

Abnormal high density lipoproteins of abetalipoproteinemia: relevance to normal HDL metabolism.

We investigated high density lipoprotein (HDL) subfractions in abetalipoproteinemia (ABL) using rate zonal ultracentrifugation. In ABL, HDL2 is the major subfraction, 65% of total mass compared to less than 10% in normal subjects with similar HDL levels. HDL2 and HDL3 in ABL (n = 3) are larger and lighter than in normals (n = 3), with mean diameters of 136 +/- 19 A and 100 +/- 12 A, respectively (as compared to 113 +/- 12 A and 86 +/- 11 A), and contained more apoprotein E. ABL-HDL2 and HDL3 particles contain 2- to 2.5-fold more cholesteryl ester molecules than normals. ABL-HDL can be modified towards normal HDL by allowing VLDL triglycerides to exchange for ABL-HDL cholesteryl esters, followed by addition of lipoprotein lipase and hydrolysis of the triglycerides. In addition, ABL plasma contains a previously undescribed small and spherical (61 +/- 8 A) protein-rich (63% by weight) HDL fraction, which we call ABL-HDL4. Our data suggest that absence of cholesteryl ester transfer to triglyceride-rich lipoprotein in ABL causes accumulation of abnormally large cholesteryl ester-rich particles.

Abetalipoproteinemia↗
PubMed1981

[Cefotaxime and Gram-negative infections in children. Effectiveness and tolerance (author's transl)].

Twenty-six children, aged from 15 days to 14 years, were treated with cefotaxime. 5 were suffering from septicaemia, 14 from respiratory tract infection and were ventilated (intensive care unit), 4 from urinary tract infection and 3 from otitis media complicated with renal failure (nephrology unit). The choice of cefotaxime treatment was based upon the bacterial activity. The daily dose was 50 to 100 mg/kg by the i.m. route, or by slow intravenous injection every 8 hours. In 17 patients, cefotaxime was combined with an aminoglycoside (gentamicin or amikacin). The results were evaluated on the basis of clinical, radiological and bacteriological criteria and, whenever possible, were correlated to the serum levels of antibiotic. The antibiotic was clinically effective in 25 out of 26 patients. The three deaths that occurred, were due to the nature of the initial disease. Tolerance was good in all the patients studied. The efficacy of cefotaxime correlated well with the favorable in vitro bacteriological results and with serum concentrations. Cefotaxime is well tolerated as shown in newborn babies. Cefotaxime is markedly different from previous cephalosporins, because of its high antibacterial activity on most Gram-negative bacilli.

Adolescent↗
PubMed1979

[Evaluation of the hypothalamo-hypophyseal-thyroid axis by means of TRH in patients with chronic open-angle glaucoma].

The diencephalo-hypophyseal axis was studied in a group of patients with chronic open-angle glaucoma by means of TRH. Nearly half of the patients studied presented with hypothalamo-hypophyseal dysfunctions. TRH increases the outflow coefficient in these patients but this increase seems to be due to a pharmacodynamic action inherent in the product, and appears prior to the release of thyroid hormone.

Chronic Disease↗
PubMed1978

Action of insulin on thyroid protein synthesis in dogs.

The study was performed on dog thyroid slices after in vivo administration of monocomponent insulin (carotid perfusion of a lobe: 25 mIU/kg/min for 15 min, and 2nd lobe perfused as control: saline) and after in vitro hormone addition (100 mIU/ml of glucose-free incubation medium). The 3H-leucine incorporation in thyroid proteins (dpm/mg) was determined following incubation of slices for 1 h and 2 h. Insulin given in situ significantly increased the mean incorporation into homogenate and cytosol proteins: about 130% after 1 h of incubation, for an identical hypoglycaemia in both lobes. When insulin was added to the medium, a similar response was observed after 1 h of incubation, the effect being less pronounced after 2 h but still significant. The sucrose gradient analysis of the soluble fraction showed that the stimulation affected all thyroid proteins. Polyribosomes isolated from in vivo insulin-perfused thyroids exhibited an increased activity when tested in cell-free system. These data suggest that insulin stimulated the thyroid protein synthesis in dogs through a direct action on the thyroid cell.

Animals↗
PubMed1978

[Presence of nuclear triiodothyronine (T3) receptors in mouse fibroblasts].

The present preliminary data obtained from intact fibroblasts of adult mice (polyploid stem L 929) suggest that this cell system possesses high-affinity and saturable nuclear binding sites for triiodothyronine. As estimated by the Scatchard analysis, the equilibrium dissociation constant is approximately 2 X 10(-10) moles, the maximal binding capacity is about 2 000 sites for T3 per cell nucleus.

Animals↗
PubMed1978

[Antibiotic therapy, intestinal microbial pullulation and risk of infection in children].

The effect of antibiotic therapy on the intestinal flora was studied qualitatively and quantitatively in 41 infants. The results have been compared with 27 normal children of the same age and background. Antibiotics were responsible for the suppression of sensitive strains and for their replacement by resistant organisms but above all to a rapid multiplication of the intestinal flora. Colistin and pristinamycin caused these changes when given orally. Ampicillin when given both orally and parenterally but Colistin and the aminoglycosides when given parenterally did not have any effect. Fourteen cases of secondary septicaemia due to resistant organisms were observed but other factors were also important, namely the young age of the patients and intestinal problems (stasis and diarrhoea).

Age Factors↗
PubMed1977

Dose-dependent effect of TRH on plasma oleic acid in man.

Administered to normal subjects of either sex, the TRH enhances the plasma oleic acid after 60 minutes without any significantly marked modification in the blood concentration of total FFA. The oleic acid increase is significantly dependent on the amount of administered TRH (200 microgram and greater than or equal to 400 microgram). It is accompanied by 1) a more or less pronounced but acute release of TSH, and 2) a rise in circulating T3 but a submaximal value within the time-course of the experiment (1 h). This elevation is presumably due to a preferential liberation of oleic acid by the adipose tissue, through a direct action of TSH and/or under the permissive influence of the thyroid hormone, among other factors that may intervene in the process.

Adult↗
PubMed1977

Effect of insulin on thyroid hormone blood levels in normal and thyroidectomized dogs.

Administration of insulin brings about an increase of thyroid hormone blood concentration. This study investigated the possibilities that the elevation is due to increased thyroid secretion or to liberation of hormone from hepatic stores. Monocomponent insulin was administered to intact dogs by jugular perfusion (25 mU/kg/min. for 15 min.) and to thyroidectomized dogs either as single dose i.m. (1 U/kg) or by jugular perfusion (as above). All animals showed at least halving of blood glucose concentration. In normal dogs, circulating labeled thyroid hormone increased with a 2-fold T3 rise. In thyroidectomized dogs, blood T3 as well as T4 remained persistently low, while plasma 125I-T4 disappearance slope was unchanged. When intact animals were held in a glycemic steady state by infusing insulin alone at low dose (0.5 mU/kg/min. for 15 min.) or insulin at the experimental dose (25 mU/kg/min. for 15 min) with simultaneous glucose infusion, blood T3, T4 and labeled PBI showed no changes. These data suggest that the increase of circulating thyroid hormones under insulin administration is due to a stimulation of thyroid secretion. The effect of insulin appears to result from induced hypoglycemia.

Animals↗