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Biomedical subjects

C Biagini

Publications and source records attributed to C Biagini.

At least 55 records · Page 3Linked to original sources
PubMed1986

Evaluation of therapeutic modalities in the control of Hodgkin's disease.

The results achieved in three different studies carried out on patients affected by Hodgkin's disease are discussed. In study No. 1, 58 patients with pathological Stage I-II were treated with only a "Mantle" field irradiation. The complete remission (CR) rate was 98% with an actuarial overall survival of 90%, and a median of follow-up of 80 months. Thirty-one percent of patients relapsed. In study No. 2, 42 patients were randomly allocated to receive only MOPP chemotherapy versus extended field irradiation; CR rate was 68 and 95%, respectively (p less than 0.05). The overall survival rate was 100% in the radiotherapy group and 82% in the MOPP group. No relapses have been observed in patients treated with MOPP. In study No. 3, 218 patients affected by advanced Stage HD were randomly treated with 6 cycles of MOPP chemotherapy versus 6 cycles of ABVD chemotherapy. In the MOPP group the CR rate, the relapse-free survival rate (RFS), and overall survival (OS) rates at 60 months were 77, 68, and 76% respectively, whereas, in the ABVD group the CR, the RFS, and OS rates at 60 months were 75, 77 and 80% respectively, (p less than 0.05). These data and statistical comparisons are analyzed.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1986

[Role of magnetic resonance imaging in the tissue characterization of tumors].

Aim of this article is to examine the possibilities and the limits of MR imaging in oncology, with special regard to the tissue characterization of tumors. Basic information is given on the fundamental parameters of MR, and the concept of image contrast is discussed, with a comparison between the image in conventional radiology and in MR. Factors affecting MR parameters and influencing the image contrast are analyzed; they are classified as extrinsic, or connected to the patient's conditions and to technical modalities, and as intrinsic or inherent to biological factors. Intrinsic factors are scheduled in three groups: a) tissue physico-chemical structure; b) functions or physiological conditions; c) pathological aspects. One of the most important factors related with the first group is water content. The possible influences of water content on the measurement of the proton MR relaxation times are numerous and complex. As a first approximation, relaxation times are directly related to water content; nevertheless many experimental results show that this statement is not sufficient to explain the observed variations of relaxation times in different tissues and organs. Some other data are accounted for the presence of different relaxation times of water in the same sample, and for the microtrabecular structure of the cell. In normal tissues and structures, further elements are explained on the basis of simple physico-chemical characteristics. In tumors the increase of T1 and T2 observed in experimental evaluations performed on samples of tissues, was largely confirmed in the images. To an equal extent failure of specificity of the increase of relaxation times of tumors is well documented in experimental research and in clinical experiences. In experimental research a strict comparison was made between the tumor and the tissue of origin. Increase of relaxation parameters appears related to the presence of larger fluid-filled areas, to the diminution of average cell size, and to reduced amount of rough and smooth endoplasmic reticulum. In clinical experiences good results are obtained in the ascertainment of the tumors localization and extension; macroscopic aspects connected to the peritumoral structures, inhomogeneities, and necrosis are well evaluated. New data are acquired in the study of early and late effects of radiation in patients submitted to radiotherapy for various types of tumors.

Animals↗
PubMed1982

Treatment by splenic irradiation in 22 chronic lymphocytic leukemia patients.

Twenty-two patients with chronic lymphocytic leukemia, score 2 according to Rai et al. (10), who received only a course of splenic irradiation are reviewed. Splenic doses ranged from 420 to 1080 rad. Response to splenic irradiation was rated by evaluating peripheral lymphocytosis, hepatosplenomegaly, adenomegaly and disease-related symptoms. Following splenic irradiation, 8 patients showed a significant reduction in splenomegaly; 7 patients showed a significant reduction in peripheral lymphocytosis (less than 10,000/mm3), which has lasted from 15-42 months without any other treatment. In 14 patients, response to splenic irradiation was partial, and it has successively been necessary to treat 12 patients with chemotherapy. Methods of splenic irradiation, survival, clinical and hematologic behavior are discussed in detail.

Adult↗
PubMedDate not supplied

Assessment of depression in Alzheimer's disease: symptoms, syndrome, and computed tomography findings.

The Hamilton Rating Scale for Depression (HAM-D) and DSM-III-R criteria were simultaneously employed to assess the prevalence of depression in 26 outpatients with dementia of the Alzheimer type and 26 age-matched normal control subjects. Both assessment methods evidenced a higher frequency of depression during the severe stages of Alzheimer's disease. Among the Alzheimer patients, the prevalence rate of depression produced by the HAM-D (38%) was higher than the rate produced by DSM-III-R criteria (23%). Such a difference was due to the weight given by the HAM-D to the vegetative symptoms reported by the Alzheimer patients with more severe dementia. In a subgroup of 14 Alzheimer patients who underwent computed tomography, the volumetric measurement of CSF spaces did not reveal any difference between the depressed and nondepressed patients. On the basis of these results, the clinical problems related to the assessment of depression in Alzheimer's disease are discussed.

Aged↗
PubMedDate not supplied

Involvement of the bone marrow by non-Hodgkin's lymphomas: incidence, histology and pathologic correlations.

The Lukes and Collins system of classification was applied to 151 cases of non-Hodgkin's lymphoma who had bone marrow biopsies taken immediately after histologic diagnosis. Incidence and histologic pattern of bone marrow involvement at the time of initial diagnosis were determined for each subtype of lymphoma. Thirty-three patients (21.8%) had bone marrow involvement. The frequency of bone marrow involvement was high for undefined and convoluted lymphocyte lymphomas (66.6%) and low to intermediate for follicular centre cell (20.3%) and small lymphocyte lymphomas (20.0%). Within the FCC lymphomas the non-cleaved cell type had a higher incidence of marrow involvement than the cleaved cell type (41.6% vs 8.9%). The follicular and diffuse histologic patterns in the diagnostic node did influence the incidence of marrow invasion in the non-cleaved cell type (75% vs 25%). A low incidence of marrow involvement was observed for the immunoblastic lymphomas (14.2%); evidence of marrow infiltration was never observed in patients with true histiocytic lymphomas.

Adolescent↗