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Biomedical subjects

C Berry

Publications and source records attributed to C Berry.

At least 199 records · Page 11Linked to original sources
PubMed1979

Step 2 regimens in hypertension. An assessment.

A single-blind clinical trial compared step 2 combination therapy consisting of 50 or 100 mg of hydroflumethiazide plus either 0.125 to 0.250 mg of reserpine, 500 to 2,000 mg of methyldopa, or 80 to 320 mg of propranolol hydrochloride, in 59 patients whose elevated blood pressure (BP) failed to respond adequately to the thiazide alone. After nine weeks of treatment, diastolic BP was reduced below 90 mm Hg in all 20 patients treated with the reserpine-hydroflumethiazide combination, in 13 of the 19 patients treated with methyldopa and hydroflumethiazide, and in 16 of the 20 patients treated with propranolol and hydroflumethiazide. Changes in laboratory values were not substantial; adverse reactions occurred only in the methyldopa group. Although the three treatment regimens were similar with respect to safety and efficacy, the reserpine-hydroflumethiazide combination offers the advantages of more convenient dosage at lower cost.

Adult↗
PubMed1978

Phospholipid dependence of UDP-glucuronyltransferase.

Very extensive hydrolysis of phospholipids with pure Bacillus cereus phospholipase C at 5 degrees C greatly inhibited the maximum demonstrable rate of glucuronidation of p-nitrophenol by UDPglucuronyltransferase in guinea pig liver microsomes. Lysophosphatidylcholine restored much of the inhibited activity but non-phospholipid surfactants or hydrolysis of diglycerides failed to reactivate. Phospholipid depletion likewise inhibited o-aminophenol glucuronidation and phospholipids restored activity. It is concluded that glucuronyltransferase specifically requires phospholipids for optimal activity. It seems unlikely that these phospholipids only serve to dissolve aglycones, or that they are direct physiological regulators of the transferase. Instead, a permissive role is ascribed to phospholipids, allowing glucuronyltransferase to be regulated by other means.

Animals↗
PubMed1975

Guinea pig liver microsomal UDP-glucuronyltransferase: compartmented or phospholipid-constrained?

1. Three mechanical methods for disrupting membranes substantially stimulated two forward reactions and a reverse reaction of UDPglucuronyltransferase (EC 2.4.1.1.7) in guinea-pig liver microsomes. Stimulation of glucuronyltransferase was highly significant and at lease as extensive as that of nucleoside diphosphatase, reportedly a marker intracisternal enzyme. 2. Stimulation of glucuronyltransferase did not appear to be caused by induction of lipid peroxidation or by lipid hydrolysis during membrane disruption. 3. Addition of phospholipid dispersions failed to significantly re-constrain glucuronyltransferase stimulated by mechanical disruption and did not markedly inhibit the enzyme in untreated control microsomes. 4. Compartmentation appears at least as feasible an explanation for the latency of glucuronyltransferase in guinea-pig liver microsomes as is its conformational constraint by membrane phospholipids. Compartmentation of glucuronyltransferase is functionally attractive since it would ensure its effective interaction with nucleoside diphosphatase on the cisternal side of the endoplasmic reticulum. This would tend to make conjugation reactions unidirectional.

Animals↗
PubMedDate not supplied

The impact of thermal injury.

From data collected by the Regional Burn Treatment Center at UCSD in San Diego and Imperial Counties in California, the incidence and economic cost of thermal injuries are extrapolated to the entire United States in order to estimate the impact of thermal injury on the public health.

Burns↗