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Biomedical subjects

C Becker

Publications and source records attributed to C Becker.

At least 91 records · Page 5Linked to original sources
PubMed1981

Disclosure standards and informed consent.

There is currently substantial disagreement about the kind of information that must be disclosed in obtaining an informed consent. This study examined physicians' interpretations of the demands of two alternative legal standards for disclosure, as well as a third standard intended to capture their normative sense of what should be disclosed to patients. Other factors which might affect disclosure practices of physicians were also studied. The findings raise questions about the extent to which a legal standard for disclosure can have an impact on medical practice; the data suggest that doctors currently disclose what they think patients want to be told. However, it appears that physicians substantially underestimate the amount of information patients wish to receive.

Disclosure↗
PubMed1981

Clinical and biochemical delineation of aspartyl-glycosaminuria as observed in two members of an Italian family.

Two members of a consanguineous Italian family are described with the symptoms of aspartylglycosaminuria. Both patients exhibit mental retardation, some facial dysmorphism and discrete radiological abnormalities affecting the skull and vertebrae. Peripheral blood smears revealed multivacuolated lymphocytes. Enzyme studies in leucocytes and cultured fibroblasts showed an absence of aspartylglucosaminidase activity. Urinary analysis demonstrated abnormal oligosacchariduria and aspartylglycosamine excretion. Angiokeratoma corporis diffusum was observed in one patient.

Abnormalities, Multiple↗
PubMed1980

[Congenital interruption of the aortic arch as an isolated malformation in adults].

It is reported on a 36-year-old patient with congenital interruption of the aorta in the preductal region. Is the infantile form of the interruption of the aortic arch already rare, so cases which reach the age of adults are absolute rarities. In the literature available to us altogether 11 cases of the adult form of an interruption of the aortic arch could be established which are supplemented by the 12th case which is described here. Among these cases interruptions in the preductal part of the aorta have been described up to now only in 4 cases of the adult age. Thus the case described here is the 5th case of this kind. As decisive for reaching the adult age the absence of further malformations on heart and large vessels are taken into consideration, further the extended collateral system, the formation of which seems to begin already in the embryonary stage and might be functionable immediately post partum.

Adult↗
PubMed1980

1,25 dihydroxycholecalciferol treatment of uraemic rats after high magnesium feeding.

The hypercalcaemic response to 1,25 dihydroxycholecalciferol (1,25(OH)2D3) treatment was studied in mild uraemic rats (5/6-nephrectomy) under conditions of varying magnesium intake of 0.05% (control) and 0.75% (experimental). After 3 weeks' exposure to the high magnesium diet a loss of the hypercalcaemic effect of 1,25(OH)2D3 when given as 40pmoles i.p. during 5 days was observed. By use of standard clearance experiments a similarity of the renal magnesium and calcium handling could be demonstrated. At high serum magnesium levels, the fraction of filtered magnesium excreted in the urine rose, concomitant with an increased fractional excretion of calcium (r=0.81). The bone magnesium content was correlated with serum levels and therefore increased after high dietary magnesium. Treatment with 1,25(OH)2D3 resulted in an increase of the bone calcium content (p less than 0.05) after low magnesium diet, but not after high magnesium feeding. It is concluded that high urinary calcium excretion after magnesium loading contributes to the impaired calcaemic response of 1,25(OH)2D3 in azotaemic rats, while calcium uptake of bone is impaired.

Animals↗
PubMed1979

[Experiences obtained with the use of schulte's diagnostic program in myoarthropathies (author's transl)].

Using Schulte's diagnostic and therapeutic system of treating the pain-dysfunction syndrome, 165 patients were included in a program of myogymnastic self-treatment. The results obtained on reexamination of 96 patients confirmed the correlations observed by Schulte between the principal symptoms (painful side and lateral deviation of the lower jaw) and numerous causal factors. The diagnostic schemes used to search for causal factors may thus be regarded as having proved successful. They allow functional temporomandibular complaints to be classed in groups of diseases by taking into account the principal symptoms alone, namely, painful side and deviation of the lower jaw upon opening the mouth.

Dental Restoration, Permanent↗
PubMed1979

[Experience in the treatment of pain-dysfunction syndromes by myogymnastic exercises with particular reference to 96 reexamined patients (author's transl)].

In 1975, a total of 165 patients with myoarthropathies were treated by myotherapy. Through the use of a program of step-by-step therapy, which included myogymnastic selftreatment in addition to psychotherpay and repair of teeth, 77.6 percent of 96 reexamined patients were made free from complaints. Fuller utilization of the possibilities of causal therapy would certainly have allowed a higher rate of success to be achieved using the simplified program of exercises described in this paper. Experimental evidence could be presented in support of the assumption that parodontal damage may be caused to uncorrected sites of abnormal occlusion in the course of myogymnastic therapy.

Dental Occlusion, Traumatic↗
PubMed1978

Frequency of church attendance and blood pressure elevation.

Blood pressure levels were examined with regard to church attendance patterns in a group of white male heads of households who appeared in the 1967-1969 follow-up examination of the Evans County Cardiovascular Epidemiologic Study. A consistent pattern of lower systolic and diastolic blood pressures among frequent church attenders was found compared to that of infrequent attenders which was not due to the effects of age, obesity, cigarette smoking, or socioeconomic status.

Age Factors↗
PubMed1977

Intra- and extrarenal vascular changes in the acute renal failure of the rat caused by mercury chloride.

Histologic evidence of intrarenal vasomotor changes were observed in the rat in the course of acute renal failure caused by the injection of HgCl2. Male Wistar rats injected s.c. with 2.5 or 4.7 mg HgCl2 per kg b. wt. developed fibrinoid damage in the media segments of preglomerular renal vessels, mostly in the arcuate and interlobular arteries. The lesions were patchy and irregularly scattered throughout the kidneys. 24 h post-injection the lesions were very rare and of only mild degree, whereas they were fully developed and regularly seen 48 h post-injection. A high percentage of similar changes was found in certain extrarenal vascular areas especially in the mesentery and pancreas. The damaged vascular segments were usually dilated. The results of various thichrome stains and histochemical reactions suggested edema of vascular smooth muscle cells and imbibition of the media by blood plasma substances, sometimes reaching the degree of fibrinoid necrosis. These findings were confirmed by electron microscopy. The imbibition of the smooth muscle cells by blood plasma material was clearly evidenced by the demonstration of intracellular fibrin precipitations. In connection with the degeneration of smooth muscle cells, accumulations of crystal-like fibrin formations could often be shown. Subendothelial fibrin formations were not observed. 96 h after the 2.5 mg injection the changes were already regressing, but edema of the vascular wall and signs of disturbed vasotonia persisted for several days. The maximum of the vascular changes usually coincided with the maximum of azotemia and the formation of debris cylinders in the renal tubules. However, no clear relationship was recognizable in individual cases between vascular damage, extent of tubular necrosis and renal function. The pathogenesis of the vascular changes is obscure, but neurogenic factors, increased release of catecholamines and/or vasoactive agents of renal origin in connection with other factors might play a decisive role. Arterial hypertension was absent. It is assumed that the structural damage of the vascular media is mainly brought about by prolonged or recurring vasospasms, or by alternating spasm and vasodilatation with local ischemia and increased tension of the vascular wall in the dilated segments. The altered function and structure of the vascular wall might, to a certain extent, contribute to renal insufficiency.

Acute Kidney Injury↗
PubMed1976

Coffee consumption and mortality in a community study--Evans Co., Ga.

Total mortality showed no association with heavy coffee consumption in the four race-sex groups of Evans County. Deaths from coronary heart disease in WM, WF and BM showed no statistically significant differences between the two coffee consuming groups. Sex differences in cerebrovascular death rates, consistent in both races, suggest the possibility for a female excess of stroke deaths among coffee drinkers, and a "protective" effect of coffee drinking among males. Thus, in an area of the United States which has been designated the "Stroke Belt", neither the cardiovascular nor the cerebrovascular death rates seem strongly nor consistently related to coffee drinking habits. Although the number of deaths (339) is fairly large, representing a 13% mortality in this community over a four and one-half year observation period, the classification in four race-sex groups with further division into the groups with different coffee drinking habits limits each stratum to rather small numbers. In addition, 86 cases of CHD and CVD were diagnosed during lifetime already and, therefore, were excluded from the prospective mortality study. Confidently to refute or confirm the allegations of a detrimental influence of high coffee intake on ischemic heart disease one would need larger numbers. But in the light of our most important finding--that mortality from all causes is not increased in the high coffee consuming group--the finding of increased ischemic heart disease death rates with high coffee consumption would have to be compensated by a provocative, lower rate for other causes of death.

Black People↗